An exceptional case of malignant glomus tumor and a review of the literature

Sacchetti, Federico; Gori, Marco De; Grossi, Stefano; Bonadio, Giovanni Angelo; Capanna, Rodolfo

doi:10.1016/j.aott.2019.04.014

Cited by 7 publications

(5 citation statements)

References 19 publications

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“…This could explain the relatively long average duration of almost four years before the diagnosis of glomus tumour was made in our case series. In fact, delayed diagnosis is often described in the literature [ 1 , 2 , 10 , 12 ]. To highlight a case example in this study, a patient presented with left big toe pain and slight bluish discoloration of the lateral aspect of his toenail (Fig.…”

Section: Discussionmentioning

confidence: 99%

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Glomus tumour: an institutional experience of 31 cases

Lee,

Li,

Yeo

2023

J Orthop Surg Res

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Background Glomus tumour is an uncommon soft tissue tumour which commonly occurs in the distal extremities, particularly the subungual region of the finger. Due to its rarity, there is a paucity of literature concerning glomus tumour. Therefore, this paper aims to report a case series based on our institution’s experience. Methods A retrospective cross sectional study was performed in a single tertiary institution in Singapore. All patients diagnosed with glomus tumour confirmed on histology from January 2019 to October 2022 were included in the study. Patient demographics and clinical information (presenting signs and symptoms, tumour parameters and presence of recurrence) were retrieved from existing medical records. Results A total of 31 cases of glomus tumour were diagnosed from January 2019 to October 2022, and the relevant demographics and clinical presentation were reported. Majority of glomus tumours occurred in the finger (61.3%). Pain was present in almost all the cases (96.8%), while a lump was visible in less than half (48.4%). An average of 44.0 months elapsed before patients were properly diagnosed and treated. There were no cases of recurrence despite involved margins in three cases. Conclusion Glomus tumour can be easily missed if clinicians do not have an index of suspicion for it, resulting in delayed treatment. Once diagnosed, glomus tumour can be treated with complete excision with good outcomes.

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Section: Discussionmentioning

confidence: 99%

“…Generally considered to be a benign neoplasm, there have been cases of malignant transformation [ 12 , 13 ]. Some of the features suggestive of malignant potential are deep location, large size > 2 cm, atypical mitotic figures, high nuclear grade and high mitotic activity > 5 mitoses/50 high power field [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Glomus tumour: an institutional experience of 31 cases

Lee,

Li,

Yeo

2023

J Orthop Surg Res

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“…They are predominantly present in palmar and plantar skin, particularly in the subungual region of the fingertips (Figure 3) [56,57]. Although these tumors are typically benign, there is a ~3% risk of malignancy, and an additional 3.6% have uncertain malignant potential [58]. The risk of malignant glomus tumors in NF1 patients is currently unknown.…”

Section: Glomus Tumormentioning

confidence: 99%

Dermatologic Manifestations of Neurofibromatosis Type 1 and Emerging Treatments

Poplausky

Young

Tai

et al. 2023

Cancers

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Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome that increases one’s risk for both benign and malignant tumors. NF1 affects every organ in the body, but the most distinctive symptoms that are often the most bothersome to patients are the cutaneous manifestations, which can be unsightly, cause pain or pruritus, and have limited therapeutic options. In an effort to increase awareness of lesser-known dermatologic associations and to promote multidisciplinary care, we conducted a narrative review to shed light on dermatologic associations of NF1 as well as emerging treatment options. Topics covered include cutaneous neurofibromas, plexiform neurofibromas, diffuse neurofibromas, distinct nodular lesions, malignant peripheral nerve sheath tumors, glomus tumors, juvenile xanthogranulomas, skin cancer, and cutaneous T-cell lymphoma.

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“…GTs are classified histologically into solid tumors, glomangiomas, and glomangiomyomas based on the predominant component [4]. GTs rarely become malignant [5].…”

Section: Introductionmentioning

confidence: 99%

Extradigital Glomangioma of the Cutaneous Chest Wall

Alyaseen

Ghadeer

Al-Ghanim³

et al. 2021

Cureus

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Glomus tumors (GTs) are rare benign tumors as a result of hyperplasia of glomus body. GT most commonly involves the subungual areas and rarely involves extra-digital sites. The clinical presentation of a glomus tumor is a triad of symptoms consisting of pain, cold intolerance, and pinpoint tenderness. Even though glomus tumors are benign, they can infrequently be malignant. Despite their benign nature, these lesions can cause disabling symptoms, therefore proper diagnosis and treatment is important. In this report, we present a 35-year-old Saudi male with a painful lesion on the right side of the chest wall at the posterior axillary line for seven years, with recent progressive growth and symptoms. Diagnosis of extra-digital glomangioma of the chest wall in this patient was confirmed by histopathology. The patient was managed by complete surgical excision of the lesion with the resolution of pain and without recurrence.

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An exceptional case of malignant glomus tumor and a review of the literature

Cited by 7 publications

References 19 publications

Glomus tumour: an institutional experience of 31 cases

Glomus tumour: an institutional experience of 31 cases

Dermatologic Manifestations of Neurofibromatosis Type 1 and Emerging Treatments

Extradigital Glomangioma of the Cutaneous Chest Wall

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