An exceedingly simple mass spectrometer interface with application to reaction monitoring and environmental analysis

Brodbelt, Jennifer S.; Cooks, R. Graham

doi:10.1021/ac00283a043

Cited by 49 publications

(17 citation statements)

References 15 publications

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“…In addition to the concentration gradient and physiochemical properties of the target analyte, both theory and experiment have shown that permeation rates are determined by properties of the membrane, including its composition, thickness, surface area and temperature. Several papers have appeared evaluating a variety of membrane geometries1, 5, 14, 16–18 and membrane materials 16. The greatest improvements in extending MIMS to less volatile molecules involve cryo‐focusing techniques19 or some form of thermally assisted desorption, typically involving heating the entire MIMS interface assembly 20–22.…”

mentioning

confidence: 99%

A coaxially heated membrane introduction mass spectrometry interface for the rapid and sensitive on‐line measurement of volatile and semi‐volatile organic contaminants in air and water at parts‐per‐trillion levels

Thompson

Creba

Ferguson

et al. 2006

Rapid Comm Mass Spectrometry

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A coaxially heated membrane introduction mass spectrometry (MIMS) sampling interface is presented that demonstrates improved on-line performance for the direct measurement of semi-volatile organic compounds (SVOCs) in air and water samples at parts-per-trillion levels. The device is based on a polydimethylsiloxane (PDMS) capillary hollow fibre membrane (HFM) in a pneumatically assisted "flow-over" configuration that is resistively heated on the membrane interior via a coaxial nichrome wire, establishing a thermal gradient counter to the analyte concentration gradient. This arrangement allows for continuous and/or pulsed heating modes, affording excellent sensitivity for the on-line measurement of SVOCs while retaining sensitivity for volatile organic compounds (VOCs). In addition, the signal response time for SVOCs is reduced substantially over conventional "flow-over" MIMS interfaces. Separation and quantitation of analytes are achieved using quadrupole ion trap tandem mass spectrometry.

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mentioning

confidence: 99%

A coaxially heated membrane introduction mass spectrometry interface for the rapid and sensitive on‐line measurement of volatile and semi‐volatile organic contaminants in air and water at parts‐per‐trillion levels

Thompson

Creba

Ferguson

et al. 2006

Rapid Comm Mass Spectrometry

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“…When the sample passes through the membrane, the analyte enters the mass spectra using the principle of pervaporation and is then ionized. This types of MS instrument have been applied to environmental analysis [9,10,11,14,17,18,19,20], online reaction monitoring [15,17,21,22,23], and human body feature detection [23,24,25,26]. By preparing different membranes with multiple permeability characteristics, MIMS can meet various detection requirements [15].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Membrane Inlet and Capillary Introduction Miniature Mass Spectrometry for Liquid Analysis

Shi

Zhang

et al. 2019

Polymers

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Membrane inlet mass spectrometry (MIMS) is commonly used for detecting the components in liquid samples. When a liquid sample flows through a membrane, certain analytes will permeate into the vacuum chamber of a mass spectrometer from the solution. The properties of the membrane directly determine the substances that can be detected by MIMS. A capillary introduction (CI) method we previously proposed can also be used to analyze gas and volatile organic compounds (VOCs) dissolved in liquids. When CI analysis is carried out, the sample is drawn into the mass spectrometer with no species discrimination. The performance of these two injection methods was compared in this study, and similar response time and limit of detection (LOD) can be acquired. Specifically, MIMS can provide better detection sensitivity for most inorganic gases and volatile organic compounds. In contrast, capillary introduction shows wider compatibility on analyte types and quantitative range, and it requires less sample consumption. As the two injection methods have comparable characteristics and can be coupled with a miniature mass spectrometer, factors such as cost, pollution, device size, and sample consumption should be comprehensively considered when choosing a satisfactory injection method in practical applications.

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“…5,11 One exception is the use of membrane introduction (MIMS), which has facilitated analysis of relatively volatile small molecules from solution including fermentors. 23,24 One such early demonstration was the online reaction monitoring of the base-catalyzed methylation of cyclohexanone using a membrane interface coupled to a triple quadrupole mass spectrometer. 23 Moreover, membranes allow for a wide variety of in situ time-resolved analysis including underwater analysis, 24−26 atmospheric analysis, 26 forensic air monitoring, 27 bioreactor monitoring, 28 and intravenous blood monitoring.…”

mentioning

confidence: 99%

“…23,24 One such early demonstration was the online reaction monitoring of the base-catalyzed methylation of cyclohexanone using a membrane interface coupled to a triple quadrupole mass spectrometer. 23 Moreover, membranes allow for a wide variety of in situ time-resolved analysis including underwater analysis, 24−26 atmospheric analysis, 26 forensic air monitoring, 27 bioreactor monitoring, 28 and intravenous blood monitoring. 29 Online MIMS technology has been the subject of several reviews.…”

mentioning

confidence: 99%

Simultaneous Online Monitoring of Multiple Reactions Using a Miniature Mass Spectrometer

et al. 2017

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Advances in chemical sampling using miniature mass spectrometer technology are used to monitor slow reactions at a frequency of ca. 180 h (on the Mini 12) with no sample carryover and with inline derivatization in the case of poorly ionizing compounds. Moreover, we demonstrate high reproducibility with a relative error of less than 10% for major components. Monitoring is enabled using a continuous-flow nanoelectrospray (CF-nESI) probe contained in a custom-built 3D-printed rotary holder. The holder position is automatically set using a stepper motor controlled by a microcontroller. Reaction progress of up to six reactions, including hydrazone formation and Katritzky transamination, can be monitored simultaneously without carryover for several hours.

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An exceedingly simple mass spectrometer interface with application to reaction monitoring and environmental analysis

Cited by 49 publications

References 15 publications

A coaxially heated membrane introduction mass spectrometry interface for the rapid and sensitive on‐line measurement of volatile and semi‐volatile organic contaminants in air and water at parts‐per‐trillion levels

A coaxially heated membrane introduction mass spectrometry interface for the rapid and sensitive on‐line measurement of volatile and semi‐volatile organic contaminants in air and water at parts‐per‐trillion levels

Comparison of Membrane Inlet and Capillary Introduction Miniature Mass Spectrometry for Liquid Analysis

Simultaneous Online Monitoring of Multiple Reactions Using a Miniature Mass Spectrometer

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