An Example of Inhibitable Anti-HI in a Group B Donor

Self Cite

Studies on seventy-five sera containing antibodies of the H‘0’I-B complex together with a survey of studies by other workers show that many of the antibodies formerly called anti-‘0’ and some of those called anti-H are in fact reacting with a joint product of the H and I genes. The serological specificities of these antibodies were shown by agglutination tests with cells of known H and I or B and I status, together with the use of neutralisation and absorption techniques. These tests revealed that many of the sera contain mixtures of antibody specificities. The occurrence of anti-H-HI antibodies is probably associated with pregnancy. An H notation based on that proposed by Wiener et al. is recommended for use in the classification of these antibodies.

Section: Morgan and Watkins And Boorman Et Alsupporting

confidence: 65%

A Study of the Antibodies of the H'O'I-B Complex with Special Reference to Their Occurrence and Notation

Voak¹,

Lodge²,

Hopkins³

et al. 1968

Self Cite

“…The serological results obtained suggest that the sera react with an antigen that requires the simultaneous presence of I and H genes (HI/IH), or I and B genes or I and A genes (IA), and the results provide evidence of an association between the two systems. Some of these antibodies may be partially inhibited by salivary blood group substances [3,4,7]. Tippett, Noades, Sanger, Race, Sausais, Holman and Buttimer [14] noted than an I antibody found by them in the serum of an i adult was inhibited by hydatid cyst fluid but not by saliva.…”

Section: Introductionmentioning

confidence: 99%

The Recognition of Water-Soluble I Blood Group Substance

Dzierźkowa-Borodej¹,

Seyfried²,

Nichols³

et al. 1970

A powerful cold auto anti-I has been found that is strongly inhibited by hydatid cyst fluid and inhibited to a varying extent by all of the 181 human saliva samples tested. The investigation showed that the inhibition effect was specific for I and that water soluble I blood group substance must be responsible. No correlation could be found between the concentration of I substance in the saliva and the presence of ABH, Lewis or Sda substances. The amount of salivary I substance secreted appears to be a constant feature of the individual. Infants at birth and i adults have high concentrations of I substance in their saliva and the amount of I substance present does not reflect the I status of the red cells.

“…Several authors have described some cold antibodies having mixed specificities which react with the associated antigens AI [2,8,13,16,20], or BI [5,16,19], or HI [6,11,[15][16][17]21]. Salmon et al [16], in 1965, studied the eluates from red cells of patients with acquired hemolytic anemia.…”

Section: Introductionmentioning

confidence: 99%

Anti-I (A+B): An Autoantibody Detecting an Antigenic Determinant of I and a Common Part to A and B

Doinel¹,

Ropars²,

Salmon³

1974

Some cold autoantibodies found in acquired hemolytic anemias react with both the A, B or H, and the I, blood group antigens. The agglutinating activity of such an autoantibody of the IgM type was studied by a quantitative method in an AB patient. This antibody agglutinated neither A, B and O red blood cells in the absence of the 1 antigen, nor the Bombay red cells. It agglutinated equally AI + and BI + red cells, and weakly the OI+ red cells. Both agglutinating activities towards the AI+ and BI+ red cells were observed to decrease simultaneously and partially upon absorption on OI + red cells, at 4°C. They disappeared simultaneously and completely upon absorption on either AI + or BI + red cells. The antibody absorbed on, and eluted from AI + red cells showed a similar agglutinating activity towards the AI + and the BI + red cells ; likewise, when it was absorbed on, and eluted from BI + red cells. The study of the antibody-agglutinating activity and of its 7S subunit activity, as well as of the inhibitory activity of the Fab fragments, led to the conclusion that the observed results were due neither to a mixture of antibodies, nor to an anti-I or an anti-HI antibody, but to a cross-reactivity between the A, B and I antigens. The antibody recognized a determinant which comprises I and some part shared by A and B. It can be named anti-I (A + B).