Abstract1 . Let (R, m) be a Noetherian local ring, I an ideal of R and M, N two finitely generated R-modules. The first result of this paper is to prove a vanishing theorem for generalized local cohomology modules which says that H j I (M, N ) = 0 for all j > dim(R), provided M is of finite projective dimension. Next, we study and give characterizations for the least and the last integer r such that Supp(H r I (M, N )) is infinite.