An examination of the working case definition of chronic fatigue syndrome

Komaroff, Anthony L.; Fagioli, Laura; Geiger, Ann M.; Doolittle, Teresa H.; Lee, Joshua; Kornish, R. James; Gleit, M; Guerriero, Rosanne T.

doi:10.1016/s0002-9343(96)90012-1

Cited by 140 publications

(61 citation statements)

References 5 publications

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“…Although the 1994 case definition addressed criticisms of prior diagnostic criteria, it was not considered definitive (9). Since being proposed, the revised case definition has not been validated and questions remain about whether it reliably distinguishes a unique disease from psychiatric disorders (11)(12)(13).…”

Section: Chronic Fatigue Syndromementioning

confidence: 99%

Developing Case Definitions for Symptom-based Conditions: the Problem of Specificity

Hyams

1998

Epidemiologic Reviews

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Section: Chronic Fatigue Syndromementioning

confidence: 99%

Developing Case Definitions for Symptom-based Conditions: the Problem of Specificity

Hyams

1998

Epidemiologic Reviews

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“…Additionally, it is not specifically stated if someone would meet this criterion if he or she has restorative sleep but other sleep problems such as difficulties falling asleep, maintaining sleep, or waking up early. Komaroff et al (1996) found that 98% of a chronically fatigued group had sleep disturbances, but only 89% reported awakening unrefreshed. To assess sleep difficulties, it is important to assess for dysfunction in areas beyond just nonrestorative sleep and include prolonged sleep (including frequent naps), disturbed sleep (e.g., inability to fall asleep or early awakening) and/or day/night reversal.…”

Section: Sleepmentioning

confidence: 99%

“…More restrictive or more liberal criteria clearly have an effect on who is classified as having CFS but these different definitions also pose difficulties in interpreting results of related studies (Komaroff et al, 1996). To deal with these problems, there have been efforts to use statistical methods to classify symptoms of individuals with severe fatigue (Janal et al, 2006;Nisenbaum et al, 1998;Sullivan et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

The Development of a Revised Canadian Myalgic Encephalomyelitis Chronic Fatigue Syndrome Case Definition

Jason

Evans

Porter

et al. 2010

American Journal of Biochemistry and Biotechnology

137

150

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Problem statement: Several investigators have indicated that case definitions for Chronic Fatigue Syndrome (CFS) are characterized by vaguely worded criteria that lack operational definitions and guidelines. The most widely used CFS case definition is the Fukuda et al. criteria, which uses polythetic criteria (i.e., patients are only required to have four out of a possible eight symptoms). Yet two of these eight symptoms (post-exertional malaise and memory/concentration problems) are an essential feature of this illness and the Fukuda et al. criteria do not require that these symptoms be present among all patients. Significant methodological problems could occur if investigators in different settings recruit samples with different percentages of these core symptoms. In contrast, the Canadian clinical case definition does require specific ME/CFS symptoms such as post-exertional malaise and memory/concentration problems. The provision of operationally explicit, objective criteria on specific key symptoms might reduce criterion variance as a source of unreliability. In addition, the use of structured interview schedules will ensure that symptoms are assessed in a consistent way across settings. Conclusion/Recommendations: In this article, we specified explicit rules for determining whether critical symptoms meet ME/CFS criteria using a revised Canadian case definition and a questionnaire has been developed to assess core symptoms. It is hoped that these developments will lead to increased reliability of this revised Canadian case definition as well as more frequent use of these criteria by investigators.

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“…The evaluation also included a structured instrument, a modified version of the CFS questionnaire [18]. This instrument assesses the signs, symptoms, and medical history to rule out other disorders.…”

Section: Medical Assessment Of Cfsmentioning

confidence: 99%

Subgrouping in Chronic Fatigue Syndrome Based on Actigraphy and Illness Severity

Zaturenskaya¹,

Jason

Torres-Harding

et al. 2009

TOBIOJ

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Participants with chronic fatigue syndrome were categorized into subtypes based on actigraphy and illness selfreport symptom severity data. Each method identified two groups of patients, one with severe and one with less severe manifestations of the illness. For both subtypes, those in the more severe category had more physical functioning problems than those in the less severe categories. However, for the illness self-report symptom group, those in the more severe category had significantly more impairment in sleep, anxiety, depression, and pain, and more concurrent psychiatric status and Fibromyalgia than those in the less severe category. In contrast, those in the more severe actigraphy subtype group in comparison to the less severe group had more impairment in quality of life and cortisol readings. These findings suggest that CFS subtypes based on symptom severity and amount of activity identify different groups of patients with varying types of impairments.

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An examination of the working case definition of chronic fatigue syndrome

Cited by 140 publications

References 5 publications

Developing Case Definitions for Symptom-based Conditions: the Problem of Specificity

Developing Case Definitions for Symptom-based Conditions: the Problem of Specificity

The Development of a Revised Canadian Myalgic Encephalomyelitis Chronic Fatigue Syndrome Case Definition

Subgrouping in Chronic Fatigue Syndrome Based on Actigraphy and Illness Severity

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