An Examination of the Role of Supramaximal Resection of Temporal Lobe Glioblastoma Multiforme

Glenn, Chad A.; Baker, Cordell M; Conner, Andrew K.; Burks, Josh D.; Bonney, Phillip A.; Briggs, Robert G.; Smitherman, Adam D.; Battiste, James; Sughrue, Michael E.

doi:10.1016/j.wneu.2018.03.072

Cited by 35 publications

(39 citation statements)

References 25 publications

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“…6,8, After reading, 18 reports were excluded owing to the absence of SPTR (n ¼ 11), absence of sufficient survival data (n ¼ 4), and article type (n ¼ 3; 2 commentaries and 1 review). This resulted in a final total of 6 studies 8,12,18,19,21,28 that were included in our systematic review and meta-analysis. The process of study inclusion is presented in the PRISMA flow diagram in Figure 1, and demographics of the included studies are presented in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Some studies used a relatively conservative SPTR procedure such as resection of additional residual 5-ALAefluorescent tissue 12,19 or resection of an additional rim (>1 cm) after GTR of the CE area. 21 However, Li et al 8 and Pessina et al 28 defined SPTR as additional resection of FLAIR abnormalities (range, >0%e100%) and 100% resection of T2weighted FLAIR hyperintense volumes in addition to GTR of the CE areas, respectively. Additionally, a very recent study defined SPTR as GTR plus frontal or temporal lobectomy, without any volumetric analysis on the T2-weighted FLAIR volumes or functionally defined borders during awake surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Our meta-analysis included 6 studies comparing SPTR and GTR, 8,12,18,19,21,28 with 1168 unique patients with GBM. Our meta-analysis resulted showed that compared with GTR, SPTR of GBM resulted in a 53% lower risk of mortality at any time during the follow-up period (HR, 0.47; 95% CI, 0.31e0.72; P ¼ 0.0005; I 2 , 68%; Figure 2).…”

Section: Meta-analysismentioning

confidence: 99%

“…All the studies were retrospective with a nonrandomized treatment assignment. Using the GRADE guidelines, the studies were assigned to the low-level 12,18,19,28 quality evidence and then possibly upgraded to a moderate level 8 or downgraded to a very low level 21 (Table 1) using previously stated mainly methodological factors such as study design, internal validity, risk of biases, and precision (Supplemental Table 1).…”

Section: Quality Of Evidencementioning

confidence: 99%

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Association Between Supratotal Glioblastoma Resection and Patient Survival: A Systematic Review and Meta-Analysis

et al. 2019

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Supplemental Table 2. Overview of Multivariate Analyses Across Studies with Adjustment for Prognostics Factors Investigator Multivariate Analysis Prognostic Factors as Variables Aldave et al., 12 2013 Yes Age, KPS score, MGMT methylation status, tumor eloquent location, preoperative tumor volume, adjuvant therapy Li et al., 8 2016 Yes Unclear, at least treatment history Eyüpoglu et al., 19 2016 No Not performed Pessina et al., 28 2017 Yes Age, extent of CE resection, tumor location Esquenazi et al., 18 2017 Yes Age, tumor volume, KPS score, intraoperative mapping, BCNU wafer Glenn et al., 21 2018 Yes MGMT methylation status, tumor laterality KPS, Karnofsky performance scale; MGMT, methylguanine-DNA methyltransferase; CE, contrast enhancing; BCNU, bis-chloroethylnitrosourea (or carmustine).

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Meta-analysismentioning

confidence: 99%

Section: Quality Of Evidencementioning

confidence: 99%

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Association Between Supratotal Glioblastoma Resection and Patient Survival: A Systematic Review and Meta-Analysis

et al. 2019

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“…The concept that surgical resection beyond the contrastenhancing boundaries improves PFS and OS was supported by further studies 59,60 including by extending the resection to include abnormality documented by diffusion tensor imaging (DTI). 61 Recently a comparison of an intralesional versus perilesional surgical resection and effect on EOR and outcome suggested that a circumferential perilesional resection of GB is associated with significantly higher rates of GTR and lower rates of neurologic complications than intralesional resection.…”

Section: Extent Of Resection In Newly Diagnosed Glioblastomamentioning

confidence: 99%

Importance and Evidence of Extent of Resection in Glioblastoma

Wykes

Zisakis

Irimia

et al. 2020

J Neurol Surg A Cent Eur Neurosurg

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Maximal safe resection is an essential part of the multidisciplinary care of patients with glioblastoma. A growing body of data shows that gross total resection is an independent prognostic factor associated with improved clinical outcome. The relationship between extent of glioblastoma (GB) resection and clinical benefit depends critically on the balance between cytoreduction and avoiding neurologic morbidity. The definition of the extent of tumor resection, how this is best measured pre- and postoperatively, and its relation to volume of residual tumor is still discussed. We review the literature supporting extent of resection in GB, highlighting the importance of a standardized definition and measurement of extent of resection to allow greater collaboration in research projects and trials. Recent developments in neurosurgical techniques and technologies focused on maximizing extent of resection and safety are discussed.

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Novel insights on genetics and epigenetics as clinical targets for paediatric astrocytoma

Johns,

Williams,

Smith

et al. 2024

Clinical & Translational Med

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Paediatric and adult astrocytomas are notably different, where clinical treatments used for adults are not as effective on children with the same form of cancer and these treatments lead to adverse long‐term health concerns. Integrative omics‐based studies have shown the pathology and fundamental molecular characteristics differ significantly and cannot be extrapolated from the more widely studied adult disease. Recent clinical advances in our understanding of paediatric astrocytomas, with the aid of next‐generation sequencing and epigenome‐wide profiling, have led to the identification of key canonical mutations that vary based on the tumour location and age of onset. These driver mutations, in particular the identification of the recurrent histone H3 mutations in high‐grade tumours, have confirmed the important role epigenetic dysregulations play in cancer progression. This review summarises the current updates of the classification, epidemiology, pathogenesis and clinical management of paediatric astrocytoma based on their grades and the ongoing clinical trials. It also provides novel insights on genetic and epigenetic alterations as diagnostic biomarkers, highlighting the potential of targeting these pathways as therapeutics for this devastating childhood cancer.

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An Examination of the Role of Supramaximal Resection of Temporal Lobe Glioblastoma Multiforme

Cited by 35 publications

References 25 publications

Association Between Supratotal Glioblastoma Resection and Patient Survival: A Systematic Review and Meta-Analysis

Association Between Supratotal Glioblastoma Resection and Patient Survival: A Systematic Review and Meta-Analysis

Importance and Evidence of Extent of Resection in Glioblastoma

Novel insights on genetics and epigenetics as clinical targets for paediatric astrocytoma

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