An Examination of the Putative Role of Melatonin in Exosome Biogenesis

Amini, Hassan; Rezabakhsh, Aysa; Heidarzadeh, Morteza; Hassanpour, Mehdi; Hashemzadeh, Shahryar; Ghaderi, Shahrouz; Sokullu, Emel; Rahbarghazi‬, Reza; Reíter, Russel J.

doi:10.3389/fcell.2021.686551

Cited by 27 publications

(26 citation statements)

References 94 publications

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“…Melatonin promotes the excretion of exosomes ( 68 ), and it promotes exosome secretion from mesenchymal stem cells also ( 69 ). Early embryonic blastomeres are totipotent stem cells ( 70 ).…”

Section: Discussionmentioning

confidence: 99%

Exogenous Melatonin Directly and Indirectly Influences Sheep Oocytes

et al. 2022

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Understanding whether and how melatonin (MT) may impact sheep oocyte development competence is central to our ability to predict how sheep oocytes will respond to artificially regulated estrus. Implanting MT can make sheep enter estrus during the non-breeding season. One study found that the blastocyst rate increased under MT treatment, while another found that the blastocyst rate decreased. Therefore, we conducted a meta-analysis of MT directly and indirectly influencing sheep oocytes. A total of 433 articles were collected from which 20 articles and 34 treatments were finally selected. A method for estimating the default value was established for the litter size analysis. We found that exogenous MT add into in vitro maturation medium was positively related to the blastocyst rate in the lab. However, subcutaneous implanting MT did not affect the in vivo ovulation rate, fertilization rate, blastocyst rate, or pregnancy rate at farm. MT did not affect the in vitro cleavage rate. However, MT improved the in vivo cleavage rate. We hypothesized that implanted MT could increase the concentration of MT in oviduct fluid in vivo, and also that in vitro MT could increase the early cleavage rate of sheep zygotes without affecting the total cleavage rate. In the analysis of oocyte apoptosis caused by injury, the results suggested that pyroptosis would be more suitable for further research. MT produces responses in all body organs, and thus implanting of MT during non-breeding seasons should consider the effect on animal welfare.

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Section: Discussionmentioning

confidence: 99%

Exogenous Melatonin Directly and Indirectly Influences Sheep Oocytes

et al. 2022

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“…The stimulated mitophagy reduces in metastatic cancer the damaged mitochondria and restores the redox-metabolic balance in these cancer cells. Usually, mitophagy displays the degradation of damaged mitochondria to impair antioxidant response ( Figure 2 B) [ 86 , 87 ].…”

Section: Therapeutics Treatments In Ebv- and -Kshv-infected Malignanciesmentioning

confidence: 99%

Nanotechnology Frontiers in γ-Herpesviruses Treatments

Granato

2021

IJMS

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Epstein–Barr Virus (EBV) and Kaposi’s sarcoma associated-herpesvirus (KSHV) are γ-herpesviruses that belong to the Herpesviridae family. EBV infections are linked to the onset and progression of several diseases, such as Burkitt lymphoma (BL), nasopharyngeal carcinoma (NPC), and lymphoproliferative malignancies arising in post-transplanted patients (PTDLs). KSHV, an etiologic agent of Kaposi’s sarcoma (KS), displays primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). Many therapeutics, such as bortezomib, CHOP cocktail medications, and natural compounds (e.g., quercetin or curcumin), are administrated to patients affected by γ-herpesvirus infections. These drugs induce apoptosis and autophagy, inhibiting the proliferative and cell cycle progression in these malignancies. In the last decade, many studies conducted by scientists and clinicians have indicated that nanotechnology and nanomedicine could improve the outcome of several treatments in γ-herpesvirus-associated diseases. Some drugs are entrapped in nanoparticles (NPs) expressed on the surface area of polyethylene glycol (PEG). These NPs move to specific tissues and exert their properties, releasing therapeutics in the cell target. To treat EBV- and KSHV-associated diseases, many studies have been performed in vivo and in vitro using virus-like particles (VPLs) engineered to maximize antigen and epitope presentations during immune response. NPs are designed to improve therapeutic delivery, avoiding dissolving the drugs in toxic solvents. They reduce the dose-limiting toxicity and reach specific tissue areas. Several attempts are ongoing to synthesize and produce EBV vaccines using nanosystems.

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“…Evidence points to immune cells as the main sites of RORα1 and RORα2 responsible for mediating melatonin effects while RZRβ is abundant in the pineal gland. RORα was shown to be an active receptor in regulating of antioxidant enzymes controling of inflammation and oxidative stress [18]. MT receptors have been found in hypothalamic suprachiasmatic nuclei, cortex cerebellum, retina, spleen, liver, genital and mammary glands, uterus, thymus, gastrointestinal tract, thrombocytes and lymphocytes [19].…”

Section: Introductionmentioning

confidence: 99%

Melatonin as the Cornerstone of Neuroimmunoendocrinology

Kvetnoy

Ivanov

Mironova

et al. 2022

IJMS

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Much attention has been recently drawn to studying melatonin – a hormone whose synthesis was first found in the epiphysis (pineal gland). This interest can be due to discovering the role of melatonin in numerous physiological processes. It was the discovery of melatonin synthesis in endocrine organs (pineal gland), neural structures (Purkinje cells in the cerebellum, retinal photoreceptors), and immunocompetent cells (T lymphocytes, NK cells, mast cells) that triggered the evolution of new approaches to the unifield signal regulation of homeostasis, which, at the turn of the 21st century, lead to the creation of a new integral biomedical discipline—neuroimmunoendocrinology. While numerous hormones have been verified over the last decade outside the “classical” locations of their formation, melatonin occupies an exclusive position with regard to the diversity of locations where it is synthesized and secreted. This review provides an overview and discussion of the major data regarding the role of melatonin in various physiological and pathological processes, which affords grounds for considering melatonin as the “cornerstone” on which neuroimmunoendocrinology has been built as an integral concept of homeostasis regulation.

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An Examination of the Putative Role of Melatonin in Exosome Biogenesis

Cited by 27 publications

References 94 publications

Exogenous Melatonin Directly and Indirectly Influences Sheep Oocytes

Exogenous Melatonin Directly and Indirectly Influences Sheep Oocytes

Nanotechnology Frontiers in γ-Herpesviruses Treatments

Melatonin as the Cornerstone of Neuroimmunoendocrinology

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