Abstract:Background: Pannexins are newly discovered proteins that were first discovered by Panchin et al. in 2000. This aim of this work was to examine the presence and function of pannexins in the porcine splenic artery (PSA) in which α 1A-adrenoceptors is present. The involvement of pannexin channels was studied using Materials and Methods: several pannexin inhibitors, i.e. mefloquine (a non-selective pannexin inhibitor), probenecid (a selective pannexin-1 inhibitor at low concentrations) and carbenoxolone (a selecti… Show more
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