An examination between census tract unhealthy food availability and colorectal cancer incidence

Gibson, Derrick C.; Prochaska, John; Yu, Xiaoying; Kaul, Sanjana

doi:10.1016/j.canep.2020.101761

Cited by 10 publications

(17 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several modifiable risk factors are involved in CRC pathogenesis such as diet, obesity, sedentary life, smoking, and moderate-to-heavy alcohol consumption [ 25 ]. Diet plays a pivotal role in CRC development [ 26 , 27 ], the consumption of unhealthy food being a significant factor in CRC development [ 28 ]. Moreover, a diet rich in red meats, processed meats, saturated animal fats, spicy foods, refined carbohydrates are associated with increased CRC development [ 27 ].…”

Section: Risk Factors In Crcmentioning

confidence: 99%

Growth Factors, PI3K/AKT/mTOR and MAPK Signaling Pathways in Colorectal Cancer Pathogenesis: Where Are We Now?

Ştefani¹,

Miricescu

Stănescu-Spînu

et al. 2021

IJMS

152

View full text Add to dashboard Cite

Colorectal cancer (CRC) is a predominant malignancy worldwide, being the fourth most common cause of mortality and morbidity. The CRC incidence in adolescents, young adults, and adult populations is increasing every year. In the pathogenesis of CRC, various factors are involved including diet, sedentary life, smoking, excessive alcohol consumption, obesity, gut microbiota, diabetes, and genetic mutations. The CRC tumor microenvironment (TME) involves the complex cooperation between tumoral cells with stroma, immune, and endothelial cells. Cytokines and several growth factors (GFs) will sustain CRC cell proliferation, survival, motility, and invasion. Epidermal growth factor receptor (EGFR), Insulin-like growth factor -1 receptor (IGF-1R), and Vascular Endothelial Growth Factor -A (VEGF-A) are overexpressed in various human cancers including CRC. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) and all the three major subfamilies of the mitogen-activated protein kinase (MAPK) signaling pathways may be activated by GFs and will further play key roles in CRC development. The main aim of this review is to present the CRC incidence, risk factors, pathogenesis, and the impact of GFs during its development. Moreover, the article describes the relationship between EGF, IGF, VEGF, GFs inhibitors, PI3K/AKT/mTOR-MAPK signaling pathways, and CRC.

show abstract

Section: Risk Factors In Crcmentioning

confidence: 99%

Growth Factors, PI3K/AKT/mTOR and MAPK Signaling Pathways in Colorectal Cancer Pathogenesis: Where Are We Now?

Ştefani¹,

Miricescu

Stănescu-Spînu

et al. 2021

IJMS

152

View full text Add to dashboard Cite

show abstract

“…Spatial analysis was applied to improve understanding of a range CRC-related issues, including the distribution and determinants, the mechanisms driving the local CRC epidemiology, the effect of preventive strategies and the barriers to seek for treatment. Often, the geospatial methods have been combined with environmental factors exposure to understand the drivers of local cancer epidemiology; however, such studies remain limited for CRC in high-incidence areas [ 11 , 42 , 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

“…Exposure to unhealthy food environments such as the availability and accessibility to unhealthy food stores may encourage the surrounding community to have less healthy diets [ 54 , 58 , 59 ]. Likewise, the absence of green spaces or recreational parks nearby for physical activity may lead to continuous physical inactivity [ 19 , 60 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

Area-Level Determinants in Colorectal Cancer Spatial Clustering Studies: A Systematic Review

Soffian

Nawi

Hod

et al. 2021

IJERPH

View full text Add to dashboard Cite

The increasing pattern of colorectal cancer (CRC) in specific geographic region, compounded by interaction of multifactorial determinants, showed the tendency to cluster. The review aimed to identify and synthesize available evidence on clustering patterns of CRC incidence, specifically related to the associated determinants. Articles were systematically searched from four databases, Scopus, Web of Science, PubMed, and EBSCOHost. The approach for identification of the final articles follows PRISMA guidelines. Selected full-text articles were published between 2016 and 2021 of English language and spatial studies focusing on CRC cluster identification. Articles of systematic reviews, conference proceedings, book chapters, and reports were excluded. Of the final 12 articles, data on the spatial statistics used and associated factors were extracted. Identified factors linked with CRC cluster were further classified into ecology (health care accessibility, urbanicity, dirty streets, tree coverage), biology (age, sex, ethnicity, overweight and obesity, daily consumption of milk and fruit), and social determinants (median income level, smoking status, health cost, employment status, housing violations, and domestic violence). Future spatial studies that incorporate physical environment related to CRC cluster and the potential interaction between the ecology, biology and social determinants are warranted to provide more insights to the complex mechanism of CRC cluster pattern.

show abstract

“…Access to healthier foods and healthier dietary patterns may affect cancer risk through mechanisms related to reducing chronic inflammation [50]. Population-based research on the impact of the food environment on cancer risk has not been well established, although two studies found some evidence of a positive association between an unhealthy food environment and colorectal cancer [20,21]. For HCC in particular, several studies have suggested that diet alteration can affect HCC risk.…”

Section: Discussionmentioning

confidence: 99%

“…Public Health 2021, 18, 5740 2 of 11 retailers) providing more opportunities to purchase nutritious options may be important in preventing and managing chronic diseases such as obesity and cardiovascular disease, as it relates to a healthy diet [17][18][19]. Two studies showed that unhealthy food availability was positively associated with colorectal cancer incidence [20,21]. While some research has examined the association between factors related to the food environment, such as geographic variability in the dietary intake of nitrate, nitrite, and nitrosodimethylamine, and liver cancer risk [22], these studies did not specifically assess the physical food environment.…”

Section: Introductionmentioning

confidence: 99%

Food Environments and Hepatocellular Carcinoma Incidence

Ton

Widener

James

et al. 2021

IJERPH

View full text Add to dashboard Cite

Research into the potential impact of the food environment on liver cancer incidence has been limited, though there is evidence showing that specific foods and nutrients may be potential risk or preventive factors. Data on hepatocellular carcinoma (HCC) cases were obtained from the Surveillance, Epidemiology, and End Results (SEER) cancer registries. The county-level food environment was assessed using the Modified Retail Food Environment Index (mRFEI), a continuous score that measures the number of healthy and less healthy food retailers within counties. Poisson regression with robust variance estimation was used to calculate incidence rate ratios (IRRs) and 95% confidence intervals (CIs) for the association between mRFEI scores and HCC risk, adjusting for individual- and county-level factors. The county-level food environment was not associated with HCC risk after adjustment for individual-level age at diagnosis, sex, race/ethnicity, year, and SEER registry and county-level measures for health conditions, lifestyle factors, and socioeconomic status (adjusted IRR: 0.99, 95% CI: 0.96, 1.01). The county-level food environment, measured using mRFEI scores, was not associated with HCC risk.

show abstract

An examination between census tract unhealthy food availability and colorectal cancer incidence

Cited by 10 publications

References 39 publications

Growth Factors, PI3K/AKT/mTOR and MAPK Signaling Pathways in Colorectal Cancer Pathogenesis: Where Are We Now?

Growth Factors, PI3K/AKT/mTOR and MAPK Signaling Pathways in Colorectal Cancer Pathogenesis: Where Are We Now?

Area-Level Determinants in Colorectal Cancer Spatial Clustering Studies: A Systematic Review

Food Environments and Hepatocellular Carcinoma Incidence

Contact Info

Product

Resources

About