An Exaggerated Inflammatory Response after CLP Correlates with a Negative Outcome

Torres, Manuel B.; Maio, Antonio De

doi:10.1016/j.jss.2004.11.025

Cited by 16 publications

(17 citation statements)

References 20 publications

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“…These observations suggest that reaching a core body temperature threshold of 28°C is an accurate and early predictor of mortality. These observations were further corroborated using a different mouse strain (A/J), which displayed a different mortality rate after CLP (13,14). A/J mice were subjected to CLP (1.5-cm cecum ligation, 16-gauge needle single puncture), and both core body temperature and mortality were monitored (Fig.…”

Section: Early Decrease In Core Body Temperature Is Predictor Ofmentioning

confidence: 65%

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Period of Irreversible Therapeutic Intervention during Sepsis Correlates with Phase of Innate Immune Dysfunction

Cauvi

Song

Vázquez

et al. 2012

Journal of Biological Chemistry

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Background: Sepsis is a major health problem that can be investigated in experimental animal models. Results: Its etiology is divided into an early therapeutically reversible phase displaying a robust inflammatory response followed by a late therapeutically irreversible stage with reduced innate immune response. Conclusion: Mortality is associated with a late immune dysfunction. Significance: This study provides information for the potential window for treatment.

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Section: Early Decrease In Core Body Temperature Is Predictor Ofmentioning

confidence: 65%

“…Male B6 mice (8 weeks old) were starved for 16 h before any intervention. CLP was performed as previously described (13). Male mice were anesthetized with isoflurane via a vaporizer at 1.5-2.5 minimum alveolar concentration.…”

Section: Methodsmentioning

confidence: 99%

Period of Irreversible Therapeutic Intervention during Sepsis Correlates with Phase of Innate Immune Dysfunction

Cauvi

Song

Vázquez

et al. 2012

Journal of Biological Chemistry

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“…We have correlated a hyperinflammatory response, in particular IL-10 levels, with an increase in mortality of B6 mice after endotoxic (6) and septic shock (8,9), respectively. Other investigations have shown a correlation between overexpression of IL-10 and a detrimental outcome after infection (30).…”

Section: Figurementioning

confidence: 99%

“…The genetic contribution to sepsis has been further supported by studies using a model of polymicrobial sepsis (8,9). A direct correlation between extremely elevated anti-inflammatory (IL-10) cytokine levels and increased mortality has been observed after peritonitis (8,9). Such studies, conducted on animals housed in identical environments and subjected to the same initiating insult, clearly illustrate that the genetic background is an important modifier of the inflammatory response and outcome.…”

mentioning

confidence: 95%

“…The frequency of mortality was also different among inbred mouse strains following injection of LPS (6). The genetic contribution to sepsis has been further supported by studies using a model of polymicrobial sepsis (8,9). A direct correlation between extremely elevated anti-inflammatory (IL-10) cytokine levels and increased mortality has been observed after peritonitis (8,9).…”

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confidence: 96%

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A Quantitative Trait Loci Analysis to Map Genes Involved in Lipopolysaccharide-Induced Inflammatory Response: Identification of Macrophage Scavenger Receptor 1 as a Candidate Gene

Fulton¹,

Reeves

Takeya

et al. 2006

The Journal of Immunology

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Septic shock, which is a major complication observed after trauma and other human diseases, is likely the product of a prolonged and poorly controlled systemic inflammatory response. Symptoms of sepsis can be partially reproduced by injection of bacterial LPS in mice. Differences in mortality between C57BL/6Jhigh and A/Jlow mice after LPS injection have been previously observed and correlated with differences in the inflammatory response between these two inbred strains. In the present study, we have mapped four loci responsible for differences in levels of LPS-induced IL-10, named modifier of IL-10, between the two strains. A locus within mouse chromosome 8 was confirmed using chromosome 8 consomic mice. This locus was further reduced in size by haplotype analysis and evaluated by the presence of potential candidate genes. The macrophage scavenger receptor 1 (Msr1) within this locus emerged as a candidate gene based on differences at the expression and structural levels between C57BL/6J and A/J mice. In comparison with wild-type (C57BL/6J) mice, Msr1 knockout mice displayed reduced levels of LPS-induced IL-10, but not of TNF-α or IL-6, confirming a specific role for this gene in the regulation of IL-10. These results suggest that Msr1 is involved in the regulation of the anti-inflammatory process, thus offering a new perspective on the molecular mechanisms involved in endotoxemia and sepsis.

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Adiponectin deficiency is associated with severe polymicrobial sepsis, high inflammatory cytokine levels, and high mortality

Uji

Yamamoto

Tsuchihashi

et al. 2009

Surgery

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An Exaggerated Inflammatory Response after CLP Correlates with a Negative Outcome

Cited by 16 publications

References 20 publications

Period of Irreversible Therapeutic Intervention during Sepsis Correlates with Phase of Innate Immune Dysfunction

Period of Irreversible Therapeutic Intervention during Sepsis Correlates with Phase of Innate Immune Dysfunction

A Quantitative Trait Loci Analysis to Map Genes Involved in Lipopolysaccharide-Induced Inflammatory Response: Identification of Macrophage Scavenger Receptor 1 as a Candidate Gene

Adiponectin deficiency is associated with severe polymicrobial sepsis, high inflammatory cytokine levels, and high mortality

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