An ex vivo animal model to study the effect of transverse mechanical loading on skeletal muscle
Marisa Sargent,
Alastair W. Wark,
Sarah Day
et al.
Abstract:In many populations like wheelchair and prosthetic users, the soft tissue is subject to excessive or repetitive loading, making it prone to Deep Tissue Injury (DTI). To study the skeletal muscle response to physical stress, numerous in vitro and in vivo models exist. Yet, accuracy, variability, and ethical considerations pose significant trade-offs. Here, we present an ex vivo approach to address these limitations and offer additional quantitative information on cellular damage. In this study, skeletal muscle … Show more
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