An Evolutionary Stress-Response Hypothesis for Chronic Widespread Pain (Fibromyalgia Syndrome)

Lyon, Pamela; Cohen, Milton; Quintner, John

doi:10.1111/j.1526-4637.2011.01168.x

Cited by 40 publications

(21 citation statements)

References 154 publications

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“…Substance P is fundamental to an evolutionarily conserved, wholeorganism stress response. 82 A study of combat veterans with posttraumatic stress dis order showed that their basal levels of substance P in the CSF were elevated, and that subsequent release of substance P was increased by psychological stress. 83 Psychological factors such as stress are the probable initiators of increased production of a variety of neuro peptides in the dorsal horn of the spinal cord, the CSF and in the nerves and tissues.…”

Section: Neuropeptides In Fibromyalgiamentioning

confidence: 98%

Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome

2015

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Although fibromyalgia and complex regional pain syndrome (CRPS) have distinct clinical phenotypes, they do share many other features. Pain, allodynia and dysaesthesia occur in each condition and seem to exist on a similar spectrum. Fibromyalgia and CRPS can both be triggered by specific traumatic events, although fibromyalgia is most commonly associated with psychological trauma and CRPS is most often associated with physical trauma, which is frequently deemed routine or minor by the patient. Fibromyalgia and CRPS also seem to share many pathophysiological mechanisms, among which the most important are those involving central effects. Nonetheless, peripheral effects, such as neurogenic neuroinflammation, are also important contributors to the clinical features of each of these disorders. This Review highlights the differing degrees to which neurogenic neuroinflammation might contribute to the multifactorial pathogenesis of both fibromyalgia and CRPS, and discusses the evidence suggesting that this mechanism is an important link between the two disorders, and could offer novel therapeutic targets.

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Section: Neuropeptides In Fibromyalgiamentioning

confidence: 98%

Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome

2015

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“…One's homeostatic state, although normally controlled automatically below our awareness, can be consciously selfmonitored (Tsay, Allen, Proske, and Giummarra, 2015). It has been suggested that the perception of one's status of homeostasis (the level of threat to one's well-being) contributes to the overall stress response implicated in chronic widespread pain (Lyon, Cohen, and Quintner, 2011). Individuals who demonstrate higher interoceptive sensitivity also demonstrate a higher capacity for self-regulation (Weiss, Sack, Henningsen, and Pollatos, 2014).…”

Section: Low Sensitivity Of Interoception Is Associated With Reduced mentioning

confidence: 99%

Reconciling movement and exercise with pain neuroscience education: A case for consistent education

Blickenstaff

Pearson

2016

Physiotherapy Theory and Practice

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This article will introduce a conceptual framework of kinesthetic education that is consistent with and reinforces pain neuroscience education. This article will also provide some specific guidance for integrating pain neuroscience education with exercise and movement in a more congruent manner. Our belief is that this will enhance the effectiveness of specific movement approaches such as graded exposure techniques. Over the past decade, a new paradigm of pain education has been explored in an effort to improve patient outcomes. Using advances in pain neuroscience, patients are educated in the biological and physiological processes involved in their pain experience. Growing evidence supports the ability of pain neuroscience education (PNE) to positively impact a person's pain ratings, disability, pain catastrophization, and movement limitations. What is often overlooked, however, is the consistency between the messages of PNE and those of other therapeutic interventions, including movement therapies. This article proposes the following: education provided in isolation will be limited in its impact, the addition of guided purposeful movement performed in a manner consistent with PNE may be vital to the desired behavioral changes, and when inconsistent messages are delivered between education and movement interventions, outcomes may be adversely impacted.

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“…The most responsive conditions in the NPCAS model for homeopathic remedy actions will involve prior sensitization of components of the stress response system, including the central nervous system. 222 For example, fibromyalgia 223 is a functional chronic pain syndrome whose primary mechanisms include central and peripheral nervous system sensitization. 208,224,225 Diverse environmental factors contribute to triggering fibromyalgia, including road traffic accidents, psychological stress, chemical exposures, and childhood abuse.…”

Section: The Mediating Processes For Homeopathic Effects Are Physiolomentioning

confidence: 99%

Testing the nanoparticle-allostatic cross-adaptation-sensitization model for homeopathic remedy effects

2013

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Key concepts of the Nanoparticle-Allostatic Cross-Adaptation-Sensitization (NPCAS) Model for the action of homeopathic remedies in living systems include source nanoparticles as low level environmental stressors, heterotypic hormesis, cross-adaptation, allostasis (stress response network), time-dependent sensitization with endogenous amplification and bidirectional change, and self-organizing complex adaptive systems. The model accommodates the requirement for measurable physical agents in the remedy (source nanoparticles and/or source adsorbed to silica nanoparticles). Hormetic adaptive responses in the organism, triggered by nanoparticles; bipolar, metaplastic change, dependent on the history of the organism. Clinical matching of the patient’s symptom picture, including modalities, to the symptom pattern that the source material can cause (cross-adaptation and cross-sensitization). Evidence for nanoparticle-related quantum macro-entanglement in homeopathic pathogenetic trials. This paper examines research implications of the model, discussing the following hypotheses: Variability in nanoparticle size, morphology, and aggregation affects remedy properties and reproducibility of findings. Homeopathic remedies modulate adaptive allostatic responses, with multiple dynamic short- and long-term effects. Simillimum remedy nanoparticles, as novel mild stressors corresponding to the organism’s dysfunction initiate time-dependent cross-sensitization, reversing the direction of dysfunctional reactivity to environmental stressors. The NPCAS model suggests a way forward for systematic research on homeopathy. The central proposition is that homeopathic treatment is a form of nanomedicine acting by modulation of endogenous adaptation and metaplastic amplification processes in the organism to enhance long-term systemic resilience and health.

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An Evolutionary Stress-Response Hypothesis for Chronic Widespread Pain (Fibromyalgia Syndrome)

Cited by 40 publications

References 154 publications

Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome

Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome

Reconciling movement and exercise with pain neuroscience education: A case for consistent education

Testing the nanoparticle-allostatic cross-adaptation-sensitization model for homeopathic remedy effects

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