An Evolutionary Algorithm With Heuristic Operator for Detecting Protein Complexes in Protein Interaction Networks With Negative Controls
Mustafa N. Abbas,
Bara’a A. Attea,
David Broneske
et al.
Abstract:Computational biology research faces a formidable challenge in the detection of complexes within protein-protein interaction (PPI) networks, critical for unraveling cellular processes, predicting functions of uncharacterized proteins, and diagnosing diseases. While evolutionary algorithms (EAs), particularly state-of-the-art methods, often partition PPI networks based on graph properties or biological semantics, their resilience to noisy or missing interactions remains an underexplored territory. In this paper… Show more
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