An evolutionarily conserved non-coding element in casein locus acts as transcriptional repressor

Kaimala, Suneesh; Kumar, Satish

doi:10.1016/j.gene.2014.10.026

Cited by 3 publications

(2 citation statements)

References 39 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alternatively, rs41965198 may be in linkage disequilibrium with the truly functional variant, since this polymorphism does not map to these ECRs. To test this hypothesis, an analysis of TFBS was performed on these three ECRs and the results suggest that this SNP does, in fact, map close to a probable long-range regulatory element [ 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Candidate Genes for Reactivity in Guzerat (Bos indicus) Cattle: A Genome-Wide Association Study

Santos

Peixoto²,

Fonseca

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

Temperament is fundamental to animal production due to its direct influence on the animal-herdsman relationship. When compared to calm animals, the aggressive, anxious or fearful ones exhibit less weight gain, lower reproductive efficiency, decreased milk production and higher herd maintenance costs, all of which contribute to reduced profits. However, temperament is a trait that is complex and difficult to assess. Recently, a new quantitative system, REATEST®, for assessing reactivity, a phenotype of temperament, was developed. Herein, we describe the results of a Genome-wide association study for reactivity, assessed using REATEST® with a sample of 754 females from five dual-purpose (milk and meat production) Guzerat (Bos indicus) herds. Genotyping was performed using a 50k SNP chip and a two-step mixed model approach (Grammar-Gamma) with a one-by-one marker regression was used to identify QTLs. QTLs for reactivity were identified on chromosomes BTA1, BTA5, BTA14, and BTA25. Five intronic and two intergenic markers were significantly associated with reactivity. POU1F1, DRD3, VWA3A, ZBTB20, EPHA6, SNRPF and NTN4 were identified as candidate genes. Previous QTL reports for temperament traits, covering areas surrounding the SNPs/genes identified here, further corroborate these associations. The seven genes identified in the present study explain 20.5% of reactivity variance and give a better understanding of temperament biology.

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of Candidate Genes for Reactivity in Guzerat (Bos indicus) Cattle: A Genome-Wide Association Study

Santos

Peixoto²,

Fonseca

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…The authors reported the presence of Evolutionary conserved sequence in vicinity of ODAM gene in almost all the mammals. 16 …”

Section: Immunoreactivity Of Milk Metabolitesmentioning

confidence: 99%

Milk metabolites and neurodegeneration: Is there crosstalk?

Thakur

Anand

2015

ANS

View full text Add to dashboard Cite

Milk has been considered as a natural source of nutrition for decades. Milk is known to be nutrient-rich which aids the growth and development of the human body. Milk contains both macro- and micronutrients. Breast milk is widely regarded as the optimal source of neonatal nutrition due to its composition of carbohydrates, proteins, minerals and antibodies. However, despite the wide use of milk products, investigations into the role of milk in degenerative diseases have been limited. This review will examine the relationship between the β-casein gene found in bovine milk and disease states by using age-related macular degeneration as an example.

show abstract

The clinical correlation of phosphatase and tensin homolog on chromosome 10, phosphorylation of AKT to an activated state, and odontogenic ameloblast–associated protein in gastrointestinal stromal tumors

McLoughlin

Nodit

Heidel

et al. 2016

Journal of Surgical Research

View full text Add to dashboard Cite

An evolutionarily conserved non-coding element in casein locus acts as transcriptional repressor

Cited by 3 publications

References 39 publications

Identification of Candidate Genes for Reactivity in Guzerat (Bos indicus) Cattle: A Genome-Wide Association Study

Identification of Candidate Genes for Reactivity in Guzerat (Bos indicus) Cattle: A Genome-Wide Association Study

Milk metabolites and neurodegeneration: Is there crosstalk?

The clinical correlation of phosphatase and tensin homolog on chromosome 10, phosphorylation of AKT to an activated state, and odontogenic ameloblast–associated protein in gastrointestinal stromal tumors

Contact Info

Product

Resources

About