An Evidence-Based Approach to COPD

Corbridge, Susan J.; Wilken, Lori; Kapella, Mary C.; Gronkiewicz, Cindy

doi:10.1097/01.naj.0000412639.08764.21

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…Chronic obstructive pulmonary disease (COPD) is the fifth leading cause of death world-wide and the third leading cause of death in the United States, affecting as many as 24 million Americans and resulting in 700,000 hospital admissions, and 124,000 deaths annually [1]. COPD, which is considered the major respiratory NCD with a 10.1% prevalence of stage II or higher COPD has been associated with low-grade systemic inflammation [2], [3].…”

Section: Introductionmentioning

confidence: 99%

A Cohort Study of the Impact of Tooth Loss and Periodontal Disease on Respiratory Events among COPD Subjects: Modulatory Role of Systemic Biomarkers of Inflammation

et al. 2013

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BackgroundIn COPD patients, fatal and non-fatal respiratory-related events are influenced by age, severity of respiratory disease, and comorbidities.ObjectivesAnalyze the effects of edentulism, periodontal disease and systemic biomarkers of inflammation on the occurrence of serious fatal and non-fatal respiratory-related events among subjects with COPD.MethodsCases were identified from Dental Atherosclerosis Risk in Communities study. Edentulism was defined as study participants without any natural teeth or implants. Participants with one or more natural teeth (comprising 11,378 subjects) were studied as dentate subjects. Periodontal disease status among dentate individuals was determined using the consensus definitions published by the joint Center for Disease Control/American Association of Periodontology working group). Adjusted Hazard Models are developed to evaluate the relationship between edentulism/periodontal disease and COPD Related Events. Models were then stratified by GOLD Stage I, II and III/IV. Serum biomarkers were also evaluated to explore the effect of systemic inflammation.ResultsA statistically significant association was found between oral health status and COPD-related events, even adjusting for conditions such as hypertension, smoking and diabetes. Edentulous individuals who had been diagnosed with COPD had a higher incidence and were at greater risk of having a COPD related event (hospitalization and death) than individuals who had teeth and whose mouths had healthy periodontal status. However, being edentulous did not convey excess risk for COPD-related events for those study participants who were classified as GOLD III/IV at baseline. Finally, we showed that individuals who had levels of serum IL-6 in the highest two quartiles were at even higher risk for COPD-related events.ConclusionsThese findings suggest that the risk for COPD-related events after adjusting for potential confounders may be attributable to both edentulism and elevated serum IL-6 levels.

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Section: Introductionmentioning

confidence: 99%

A Cohort Study of the Impact of Tooth Loss and Periodontal Disease on Respiratory Events among COPD Subjects: Modulatory Role of Systemic Biomarkers of Inflammation

et al. 2013

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“…The major risk factor is smoking, but poor air quality may be implicated as well. COPD is the third leading cause of death in the United States, and fifth leading cause globally . It is expected to become the fourth leading cause of death globally by 2030 .…”

Section: Discussionmentioning

confidence: 99%

“…COPD is the third leading cause of death in the United States, and fifth leading cause globally. 36 It is expected to become the fourth leading cause of death globally by 2030. 37 In the United States, COPD affects an estimated 24 million adults, and results in 700,000 hospital admissions and 124,000 deaths annually (U.S. CDC).…”

Section: Complete Edentulism Respiratory Diseases and Copd (Tables mentioning

confidence: 99%

Complete Edentulism and Comorbid Diseases: An Update

Felton

2015

Journal of Prosthodontics

112

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The relationship between complete edentulism, which is the terminal outcome of a multifactorial oral disease process and other comorbid diseases, was first reported in 2009. Although the relationship between edentulism and a multitude of systemic diseases was reported, none of the publications studied could determine causality of tooth loss on the incidence of any comorbid disease. Since that publication, there has been a renewed interest in this relationship, and a plethora of new articles have been published. This article will provide an update on articles published since 2008 on the relationship between edentulism and comorbid diseases, and will include the relationship between complete edentulism and such comorbid conditions as malnutrition, obesity, cardiovascular disease, rheumatoid arthritis, pulmonary diseases (including chronic obstructive pulmonary disease), cancer, and even mortality.

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“…COPD is the third leading cause of death in the United States, affecting as many as 24 million Americans and resulting in 700,000 hospital admissions, and 124,000 deaths annually [11]. COPD is also an inflammatory disease characterized by the progressive deterioration of pulmonary function and increasing airway obstruction, includes chronic bronchitis and emphysema [12].…”

Section: Introductionmentioning

confidence: 99%

Periodontal Disease and Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Observational Studies

et al. 2012

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BackgroundMany epidemiological studies have found a positive association between periodontal disease (PD) and risk of chronic obstructive pulmonary disease (COPD), but this association is varied and even contradictory among studies. We performed a meta-analysis to ascertain the relationship between PD and COPD.MethodsPubMed and Embase database were searched up to January 10, 2012, for relevant observational studies on the association between PD and risk of COPD. Data from the studies selected were extracted and analyzed independently by two authors. The meta-analysis was performed using the Comprehensive Meta-Analysis software.ResultsFourteen observational studies (one nested case-control, eight case-control, and five cross-sectional) involving 3,988 COPD patients were yielded. Based on random-effects meta-analysis, a significant association between PD and COPD was identified (odds ratio = 2.08, 95% confidence interval = 1.48–2.91; P<0.001), with sensitivity analysis showing that the result was robust. Subgroups analyses according to study design, ethnicity, assessment of PD/COPD, and adjusted/unadjusted odds ratios also revealed a significant association. Publication bias was detected.ConclusionsBased on current evidence, PD is a significant and independent risk factor of COPD. However, whether a causal relationships exists remains unclear. Morever, we suggest performing randomized controlled trails to explore whether periodontal interventions are beneficial in regulating COPD pathogenesis and progression.

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An Evidence-Based Approach to COPD

Cited by 5 publications

References 23 publications

A Cohort Study of the Impact of Tooth Loss and Periodontal Disease on Respiratory Events among COPD Subjects: Modulatory Role of Systemic Biomarkers of Inflammation

A Cohort Study of the Impact of Tooth Loss and Periodontal Disease on Respiratory Events among COPD Subjects: Modulatory Role of Systemic Biomarkers of Inflammation

Complete Edentulism and Comorbid Diseases: An Update

Periodontal Disease and Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Observational Studies

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