An evaluative review on Stryphnodendron adstringens extract composition: Current and future perspectives on extraction and application

Ribeiro, Maurício M. de Souza; Santos, Luana C. dos; Novais, Nathália Stahl de; Viganó, Juliane; Veggi, Priscila C.

doi:10.1016/j.indcrop.2022.115325

Cited by 16 publications

(6 citation statements)

References 180 publications

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“…Vegetal matrix contains a wide range of bioactive components. Te selection of the right and efcacious extraction method constitutes a determinant factor to predict the benefcial properties of the extract under study [43][44][45]. It has been found that the phytochemical profle of plants is highly infuenced by several biological factors, such as genotype, and organ, ontogeny, as well as edaphic and climatic conditions (temperature, salinity, water stress, and light intensity) [46].…”

Section: Efects Of Solvent On Extraction Yield Phenol Content Andmentioning

confidence: 99%

Effects of Different Solvents on the Total Phenol Content, Total Flavonoid Content, Antioxidant, and Antifungal Activities of Micromeria graeca L. from Middle Atlas of Morocco

El Kamari,

El Omari,

El-Mouhdi

et al. 2024

Biochemistry Research International

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Micromeria graeca L. is a dense chemical source of bioactive compounds such as phenolic compounds, which have various health-related properties. The current study aimed to investigate the impact of different extractor solvents on phenol and flavonoid contents, as well as the antioxidant and antifungal activities of different extracts. Initially, three extractor solvents (methanol, ethyl acetate, and water) were used to prepare the Soxhlet extracts, which were then examined for their polyphenolic content, flavonoid content, and antioxidant potential using three complementary assays (DPPH, FRAP, and TAC). The antifungal capacity against the two fungal strains (Candida albicans and Aspergillus niger) was performed using the method of diffusion on disc. The dosage of phytochemical compounds revealed that the highest values were established in water extract with values of 360 ± 22.1 mg GAE/g dry weight plant and 81.3 ± 21.2 mg RE/g dry weight plant for TPC and TFC, respectively. In addition, the strongest antioxidant activity measured by DPPH and FRAP assays was established in water extract with IC50 values of 0.33 ± 0.23 and 0.23 ± 0.12 mg/mL, respectively, while the methanol extract showed the best antioxidant activity as measured by TAC with an IC50 of 483 ± 17.6 mg GAEq/g dry weight plant. The water extract recorded the most important antifungal activity against Candida albicans with an inhibition zone of 16 ± 1.6 mm and MFC = 500 μg/mL, whereas ethyl acetate extract showed the lowest activity against both studied fungi strains. Micromeria graeca L. contains considerable amounts of bioactive contents with high antioxidant and antifungal potentials, which may make it a promising source of antioxidants and natural antifungal agents.

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Section: Efects Of Solvent On Extraction Yield Phenol Content Andmentioning

confidence: 99%

Effects of Different Solvents on the Total Phenol Content, Total Flavonoid Content, Antioxidant, and Antifungal Activities of Micromeria graeca L. from Middle Atlas of Morocco

El Kamari,

El Omari,

El-Mouhdi

et al. 2024

Biochemistry Research International

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“…One of the native trees commonly used is known as "barbatimão"-Stryphnodendron adstringens (Mart. ; S. adstringens) Coville, from which stem barks are prepared as decoctions or infusions been characterized by folk medicine as a cicatrizing, astringent, anti-inflammatory, and antimicrobial plant [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Stryphnodendron adstringens have a modulatory effect on inflammatory cytokines markers of in vitro activated macrophages

da Cruz,

Teixeira,

Pellenz

et al. 2024

Explor Drug Sci

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Aim: The purpose of this study is to conduct a comprehensive investigation into the modulatory effects of Stryphnodendron adstringens (Mart.; S. adstringens), a Brazilian wound-healing plant, on the expression of inflammatory cytokines. This will be achieved using an in vitro protocol with the commercial macrophage cell line RAW 264.7. Methods: The macrophage inflammatory response was induced by the natural antigen phytohemagglutinin (PHA), with and without supplementation of different concentrations of S. adstringens extract. The effects on cell proliferation rate and the concentration and production of transcripts of pro-inflammatory cytokines interleukin 1β (IL-1β), IL-6, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ), as well as the anti-inflammatory cytokine IL-10, were assessed using spectrophotometric, immunoassay, and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) techniques. Results: S. adstringens extract at all concentrations tested here reduced the cellular proliferation rate of activated macrophages. Extracts at concentrations of 0.49 mg/mL and 0.99 mg/mL decreased the protein and gene expression of pro-inflammatory cytokines, exhibiting the opposite effect concerning IL-10. Conclusions: The findings suggest that the wound-healing action of S. adstringens may encompass differential modulation of inflammation associated with tissue injury.

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“…S. adstringens is a specie belonging to the Fabaceae family, subfamily Mimosoideae, popularly known in Brazil as barbatimão (FERNANDES et al, 2022;LIMA et al, 2022;TROPICOS, 2022). It is widely used as an antiseptic (SOARES et al, 2008;SOUZA et al, 2007), anti-inflammatory (FALCÃO et al, 2005) a wound healing (RIBEIRO et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

In vitro culture of Stryphnodendron adstringens Mart. Coville

Ferreira Nogueira,

Paiva,

Peixoto Vargas

et al. 2023

PCC&M

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Stryphnodendron adstringens (Mart.) Coville is a species native to Cerrado with high medicinal potential. It is an important tannin source, is used mainly due to its healing, anti-inflammatory, and anti-septic activities. Due to the difficulties in sexual propagation, the objective of this work was to study some aspects of its the in vitro culture. The concentration of salts influenced the establishment of the initial explant in vitro, with a higher percentage of germination in the culture medium without salts. The combination of concentrations of 1.0 mg L -1 BAP and 0.1 mg L -1 NAA promoted greater shoot formation, and the concentration of 2.0 mg L -1 IBA promoted greater histogenesis. The composition of the culture medium influenced the establishment and development of S. adstringens.

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An evaluative review on Stryphnodendron adstringens extract composition: Current and future perspectives on extraction and application

Cited by 16 publications

References 180 publications

Effects of Different Solvents on the Total Phenol Content, Total Flavonoid Content, Antioxidant, and Antifungal Activities of Micromeria graeca L. from Middle Atlas of Morocco

Effects of Different Solvents on the Total Phenol Content, Total Flavonoid Content, Antioxidant, and Antifungal Activities of Micromeria graeca L. from Middle Atlas of Morocco

Stryphnodendron adstringens have a modulatory effect on inflammatory cytokines markers of in vitro activated macrophages

In vitro culture of Stryphnodendron adstringens Mart. Coville

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