An evaluation on the efficacy and safety of amlexanox oral adhesive tablets in the treatment of recurrent minor aphthous ulceration in a Chinese cohort: a randomized, double-blind, vehicle-controlled, unparallel multicenter clinical trial

Liu, Jie; Zeng, Xin; Chen, Qianming; Cai, Yang; Chen, Fangchun; Wang, Yan; Zhou, Hongmei; Lin, Mei; Shi, Jing; Wang, Zhi; Zhang, Yuanyuan

doi:10.1016/j.tripleo.2005.12.014

Cited by 78 publications

(48 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Two measurements were multiplied (length x width) to represent the crosssectional area of the lesion. The Efficacy Indices [14] (EI) of the lycopene and prednisolone treatments was calculated on the basis of change in REU severity score of lesions (Table 1).…”

Section: Patientsmentioning

confidence: 99%

Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus- A Randomized, Double Blind Clinical Trial.

Kushwaha¹

2017

WJPPS

View full text Add to dashboard Cite

Oral lichen planus (OLP) is a chronic inflammatory, immunologically mediated mucocutaneous disorder. Numerous topical and systemic therapies have been used in the treatment of OLP. Most of the current available treatments are palliative rather than curative. Corticosteroids are considered as the main treatment drugs. Unfortunately, some patients may develop refractory or resistance to corticosteroids therapy. This study aims to evaluate and compare the efficacy of lycopene and prednisolone in the management of OLP. This was a double-blind randomized comparative study in which clinically and histopathologically proven symptomatic OLP patients were enrolled and divided into two groups. Lycopene group received oral lycopene 4 mg/day (n=13) and prednisolone group received oral prednisolone 40 mg/day (n=15) for eight consecutive weeks. Assessments were made at baseline and after 2, 4, 6 and 8 weeks of treatment, based on the Numerical Rating Scale (NRS) and the Piboonniyom REU (Reticular, Erythematous and Ulceration) severity score. From the results obtained, the reduction of NRS burning sensation scores was statistically significant after two weeks of treatment in both groups. REU severity scores were decreased by 74% (p=0.005) and 91% (p=0.001) in lycopene and prednisolone groups respectively. Complete remission (EI=100%) of lesion was observed in two (15.4%) patients treated with lycopene and ten (66.7%) patients treated with prednisolone. However, the overall treatment response was

show abstract

Section: Patientsmentioning

confidence: 99%

Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus- A Randomized, Double Blind Clinical Trial.

Kushwaha¹

2017

WJPPS

View full text Add to dashboard Cite

show abstract

“…[7][8][9] In particular, anti-inflammatory and immunomodulatory agents such as clofazimine, thalidomide, pentoxifylline, colchicine, levamisole, azathioprine, amlexanox, and steroids have been administered with varying clinical benefits. [10][11][12][13][14][15][16][17][18][19][20] Cyclosporine A (CsA) is a potent immunosuppressive agent that interferes with both B-and T-cell activation. It is widely used to prevent organ transplant rejection and in the treatment of various systemic and local immune diseases.…”

Section: Introductionmentioning

confidence: 99%

A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cyclosporine A solid lipid nanoparticles: in vivo/in vitro examinations

Karavana¹,

Gökçe²,

Rençber³

et al. 2012

IJN

View full text Add to dashboard Cite

Aim:To develop a suitable buccal bioadhesive gel formulation containing cyclosporine A solid lipid nanoparticles (CsA SLNs) for the treatment of recurrent aphthous stomatitis. Methods: The suitability of the prepared formulations for buccal application was assessed by means of rheological studies, textural profile analysis, and ex vivo drug-release studies. Plastic flows, typical gel-like spectra, and suitable mechanical properties were obtained from prepared formulations. The retention time was explored in in vivo distribution studies and the effect of the gel containing CsA SLNs on the healing of oral mucosal ulceration was investigated in an animal model. In vivo distribution studies are a very important indicator of the retention time of formulations at the application site. Results: Distribution studies showed that 64.76% ± 8.35% of the formulation coded "F8+SLN" remained on the buccal mucosa 6 hours after application. For the second part of the in vivo experiments, 36 rabbits were separated into three groups: the first group was treated with the gel formulation without the active agent; the second group with the gel formulation containing CsA SLNs; and the third group, used as the control group, received no treatment. Wound healing was established by scoring of the rate of wound healing on Days 3, 6, 9, and 12. Histological observations were made on the same days as the scoring studies. The bioadhesive gel formulation that included CsA SLNs increased the rate of mucosal repair significantly. Conclusion: This study has shown that the bioadhesive gel formulation containing CsA SLNs reported here is a promising candidate for the topical treatment of recurrent aphthous stomatitis.

show abstract

“…3 It is known to be safe when used as an intra-oral paste. 4 It is available as 5% gel preparation in India (5% Lexanox, Macleods Pharmaceuticals, Ltd. India) and also in some countries as a tablet that adheres in the mouth. 4 Topical application of steroids for erosive lichen planus/lichenoid reaction is also used.…”

Section: Oral Medicine Amlexanoxmentioning

confidence: 99%

“…4 It is available as 5% gel preparation in India (5% Lexanox, Macleods Pharmaceuticals, Ltd. India) and also in some countries as a tablet that adheres in the mouth. 4 Topical application of steroids for erosive lichen planus/lichenoid reaction is also used. However, this may cause local immunosuppression, and lead to candidosis.…”

Section: Oral Medicine Amlexanoxmentioning

confidence: 99%

Oral medicine: Amlexanox

Ballal¹,

Jothi²

2014

Br Dent J

View full text Add to dashboard Cite

An evaluation on the efficacy and safety of amlexanox oral adhesive tablets in the treatment of recurrent minor aphthous ulceration in a Chinese cohort: a randomized, double-blind, vehicle-controlled, unparallel multicenter clinical trial

Cited by 78 publications

References 23 publications

Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus- A Randomized, Double Blind Clinical Trial.

Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus- A Randomized, Double Blind Clinical Trial.

A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cyclosporine A solid lipid nanoparticles: in vivo/in vitro examinations

Oral medicine: Amlexanox

Contact Info

Product

Resources

About