An evaluation of thiram toxicity on cultured human skin fibroblasts

Cereser, Catherine; Boget, Sophie; Parvaz, Parviz; Revol, A

doi:10.1016/s0300-483x(01)00347-x

Cited by 39 publications

(22 citation statements)

References 24 publications

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“…1) are both located on a geographical line running East-West in Burkina Faso, approximately 30 Km south of the capital Ouagadougou; whereas most of the other villages, of which several showed over all negative results (Bani, You, Kindi, Zorgho), are located north of this line. Since the effect of E. alba extract in both villages (Diapangou and Ipendo) appeared to be positive and robust (20-40% yield increase, 17 and 24 field tests respectively, Fig.1), it could make sense to focus solely on the plant extract since the pesticide, Calthio C, is toxic to humans (Cereser et al, 2001;Pino et al, 2015) and protective measures for farmers using this agent in Burkina Faso are insufficient (Toe et al, 2013). In addition, the plant, E. alba, can easily be found near the two villages Diapangou and Ipendo (Zida et al, unpublished results).…”

Section: Factors Influencing the Effect Of Seed Treatmentmentioning

confidence: 99%

Effect of sorghum seed treatment in Burkina Faso varies with baseline crop performance and geographical location

Zida¹,

Néya²,

Soalla³

et al. 2016

Afr. Crop Sci. J.

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Section: Factors Influencing the Effect Of Seed Treatmentmentioning

confidence: 99%

Effect of sorghum seed treatment in Burkina Faso varies with baseline crop performance and geographical location

Zida¹,

Néya²,

Soalla³

et al. 2016

Afr. Crop Sci. J.

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“…Among these agricultural chemicals, the action mechanism of ziram is not known. However, both paraquat and thiram are known to induce oxidative stress (Cereser et al, 2001;Suntres, 2002). Therefore, based on our observations, we could suggest that ziram also acted by inducing oxidative stress.…”

Section: Discussionmentioning

confidence: 55%

Evaluation of Action Mechanisms of Toxic Chemicals Using JFCR39, a Panel of Human Cancer Cell Lines

Nakatsu

Nakamura²,

Yamazaki³

et al. 2007

Mol Pharmacol

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We previously established a panel of human cancer cell lines, JFCR39, coupled to an anticancer drug activity database; this panel is comparable with the NCI60 panel developed by the National Cancer Institute. The JFCR39 system can be used to predict the molecular targets or evaluate the action mechanisms of the test compounds by comparing their cell growth inhibition profiles (i.e., fingerprints) with those of the standard anticancer drugs using the COMPARE program. In this study, we used this drug activity database-coupled JFCR39 system to evaluate the action mechanisms of various chemical compounds, including toxic chemicals, agricultural chemicals, drugs, and synthetic intermediates. Fingerprints of 130 chemicals were determined and stored in the database. Sixty-nine of 130 chemicals (ϳ60%) satisfied our criteria for the further analysis and were classified by cluster analysis of the fingerprints of these chemicals and several standard anticancer drugs into the following three clusters: 1) anticancer drugs, 2) chemicals that shared similar action mechanisms (for example, ouabain and digoxin), and 3) chemicals whose action mechanisms were unknown. These results suggested that chemicals belonging to a cluster (i.e., a cluster of toxic chemicals, a cluster of anticancer drugs, etc.) shared similar action mechanism. In summary, the JFCR39 system can classify chemicals based on their fingerprints, even when their action mechanisms are unknown, and it is highly probable that the chemicals within a cluster share common action mechanisms.Determining the action mechanism or identifying the molecular target of a chemical with pharmacological activity or adverse side effects is highly desirable. Although various test methods are currently available for determining the action mechanisms of chemicals, such as methods based on animal models, methods based on cellular models, bacterial mutagenicity test, the uterotropic assay (Kanno et al., 2002), Hershberger test (Hershberger et al., 1953), and the reporter assay for the nuclear receptor agonists, determination of the action mechanisms of pharmacologically active chemicals, including the toxic chemicals, is still a difficult and challenging task. Therefore, it is highly desirable to develop efficient test methods for evaluating toxicity of chemicals.A number of screening methods are currently available for discovering new anticancer drugs. One very powerful and unique approach using multiple cancer cell lines was developed at NCI (Paull et al

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“…Adicionalmente, a presença desse composto no ambiente pode ser também atribuída a processos de oxidação de dois outros fungicidas amplamente empregados: Derbam e Ziram. 66 O Tiram apresenta solubilidade moderada em água (30 mg/L) e um K ow de 1,7 (Tabela 2). 27 A persistência do Tiram no ambiente aquático é fortemente influenciada pelo pH do meio, sendo degradado por hidrólise e fotólise.…”

Section: Tiramunclassified

Tintas anti-incrustantes de terceira geração: novos biocidas no ambiente aquático

2011

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Recebido em 7/6/10; aceito em 11/1/11; publicado na web em 1/4/11 THIRD GENERATION ANTIFOULING PAINTS: NEW BIOCIDES IN THE AQUATIC ENVIRONMENT. Antifouling agents have been used on vessels and boats since ancient civilizations. Thus, a brief history on the three generations of antifouling paints was provided in the present review. Additionally, information about physic-chemical properties, environmental levels, toxicology and analytical methods was discussed for the 16 "new" booster biocides used as third-generation antifouling paints. The main problems, limitations and future trends related to this subject were also presented. Finally, actions were suggested in order to appraise the current status of the environmental impact caused by these compounds in South America.Keywords: antifouling; paint; booster biocides. INTRODUÇÃODentre os diversos grupos de contaminantes orgânicos potencialmente danosos a ecossistemas aquáticos, despontaram nos últimos anos os biocidas utilizados como princípio ativo de tintas antiincrustantes. Essas tintas são aplicadas como sistemas de proteção, com a finalidade de combater a formação e o estabelecimento de comunidades bioincrustantes (fouling) sobre superfícies expostas à água. Usualmente, tintas anti-incrustantes são aplicadas em embarcações comerciais e de passeio, plataformas petrolíferas, tubulações submarinas, comportas de represas, tanques destinados à aquicultura, dentre outras estruturas. 1Dentre as aplicações mencionadas para as referidas tintas, a utilização como revestimento protetor em embarcações tem sido apontada por muitos autores como a mais impactante para o ambiente, devido ao seu caráter altamente difundido em zonas costeiras.2 Segundo Kotrikla, 3 o emprego de sistemas anti-incrustantes em embarcações é justificado pelos seguintes motivos: o aumento da fricção entre o casco e a água, demanda uma maior potência dos motores e, consequentemente, gera um aumento no consumo de combustível; aumento da frequência de docagens, gerando um incremento de custos e de resíduos gerados; aumento das taxas de corrosão e, introdução não intencional de espécies exóticas em ambientes aquáticos.O primeiro registro de uso de sistemas anti-incrustantes data de 2 mil anos atrás, quando os cascos de madeira eram revestidos com chumbo e "untados" com misturas de óleo de baleia, enxofre e arsênio. Em 1625, uma receita letal combinando arsênio, cobre e goma em pó foi patenteada como agente anti-incrustante por Wilian Beale, na Inglaterra. A utilização de sistemas anti-incrustantes incorporados às tintas passou a ser comum, e cada vez mais frequente, na medida em que os cascos de madeira das embarcações foram substituídos por cascos metálicos, fato ocorrido em meados do século XVIII. A partir de então, a navegação comercial e o uso de embarcações de lazer se tornaram cada vez mais populares, aportando aos ambientes aquáticos quantidades cada vez maiores de biocidas utilizados em tintas anti-incrustantes. 1Em meados do século XX, os óxidos de cobre e de zinco foram os primeiros biocidas ut...

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An evaluation of thiram toxicity on cultured human skin fibroblasts

Cited by 39 publications

References 24 publications

Effect of sorghum seed treatment in Burkina Faso varies with baseline crop performance and geographical location

Effect of sorghum seed treatment in Burkina Faso varies with baseline crop performance and geographical location

Evaluation of Action Mechanisms of Toxic Chemicals Using JFCR39, a Panel of Human Cancer Cell Lines

Tintas anti-incrustantes de terceira geração: novos biocidas no ambiente aquático

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