An Evaluation of Therapeutic Results in Essential Hypertension

David Ayman, MD: An Early Investigator of Clinical Hypertension

“…did not have secondary causes of hypertension, malignant hypertension, or severe target organ damage. 1 All were symptomatic. Symptoms included insomnia, headache, nervousness, fatigue, weakness, loss of appetite, and dizziness.…”

“…1930;95:246-249. 1 The Journal of Clinical Hypertension (ISSN 1524-6175) is published monthly by Le Jacq Ltd., Three Parklands Drive, Darien, CT 06820-3652. Copyright ©2005 by Le Jacq Ltd., All rights reserved.…”

“…We were intrigued by a list of purported antihypertensive agents of the early 20th century found in a 1930 Journal of the American Medical Association. 1 The author, Dr. David Ayman, had challenged the validity of studies that showed these agents to be effective. He conducted a single-blind placebocontrolled study from which he concluded that the alleged antihypertensive efficacy was entirely explained by placebo effect.…”

Atrial Fibrosis Is a Morphological Basis of Atrial Fibrillation

“…Правда, с годами набор лекарств, из которых приходится выбирать, существенно меняется. Взглянув, например, на список лекарств (достаточно об-ширный), предлагавшийся для лечения артериальной гипертонии (АГ) менее 100 лет тому назад [1], мы не найдем в нем ни одного препарата, использующегося в настоящее время.Внедрение методов объективной оценки эффек-тивности лекарственных препаратов, базирующихся на результатах современных контролируемых исследо-ваний, предоставило возможность делать выбор ле-карства максимально научно обоснованным. Позиции доказательной медицины в вопросе выбора лекарст-венного препарата в силу ряда причин оказались осо-бенно сильны в кардиологии.…”

Thiocyanate and Basal Blood Pressure

“…For example, Ayman (1930Ayman ( , 1931 endeavoured to show that their effect was nm,i not greater than that of placebos, basing his criteria of action mainly on symptomatic improvement and not so much on pressure changes. 0\ Evans and Loughnan (1939) There have been, however, a number of careful investigations (Daley et al, 1943 ;Beamish and Adamson, 1945;Watkinson and Evans, 1947) in which every precaution was taken to control and standardize conditions and in which it would seem that thiocyanates did produce significant falls in the systolic and diastolic blood pressures.…”