An evaluation of the sensitivity of subjects with peanut allergy to very low doses of peanut protein: A randomized, double-blind, placebo-controlled food challenge study

The Application of PCR-Based Methods in Food Control Agencies – A Review

“…A need for careful labelling of food and food ingredients is strongly underscored by the fact that in some cases, even very minute amounts of an allergen can trigger such life-threatening anaphylactic responses like biphasic anaphylaxis and vasodilation, requiring immediate emergency intervention. Threshold doses for peanut allergic reactions have been found to range from as low as 100 µg up to 1g of peanut protein (Hourihane et al, 1997, Poms et al, 2007.…”

Oral immunotherapy for the treatment of peanut allergy: systematic review of six case series studies

“…This is, however, far from straightforward given the now widespread use of peanuts in a variety of foods. [13][14][15] The quality of life of affected individuals may be reduced because of constant fear over food choices and the associated risk of triggering severe reactions including anaphylaxis. 16 People with peanut allergy therefore also need to be trained in emergency selfmanagement with adrenaline (epinephrine) auto-injectors and/or antihistamines if accidental exposure occurs.…”

Key issues for the assessment of the allergenic potential of genetically modified foods: breakout group reports.

“…Data from food-challenge studies in humans were provided for a number of the known allergenic foods (e.g., peanut, shrimp, milk, egg, soybean, tree nuts) that demonstrated the existence of a threshold level for eliciting an allergic reaction to either the food or the purified allergenic food protein (Table 1). For example, Hourihane et al (1997) and Wensing et al (2001) both reported a threshold of 100 µg total peanut protein or 6 µg of the peanut allergen Ara h2, and a no-observable effect level (NOEL) of between 30 and 50 µg peanut protein or 2-3 µg of Ara h2 in patients with peanut allergy, using DBPCFCs. From this study, the authors concluded that the threshold dose of peanut protein needed to elicit a response in a group of individuals allergic to peanuts varies.…”

“…Oropharyngeal itching 50 peanut protein or 3 Ara h2 (Hourihane et al 1997) (Hourihane et al 1997) (Hourihane et al 1997 Sucrose synthetase < 1% of total protein d < 500,000 wheat or 5,000 allergen Skin, gastrointestinal, 500,000 was the first dose (Sicherer et al 2000) and/or respiratory (Sicherer et al 2000) reactions Tree nuts Cor a1…”