An evaluation of the safety and efficacy of bimatoprost for eyelash growth in pediatric subjects

Borchert, Mark; Bruce, Suzanne; Wirta, David; Yoelin, Steven G; Lee, Sungwook; Mao, Cheri; VanDenburgh, Amanda M.

doi:10.2147/opth.s89561

Cited by 12 publications

(15 citation statements)

References 18 publications

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“…Bimatoprost was hypothesized to boost eyelash growth by activating prostamide-sensitive receptors related to HFs. This enhances the conversion of the follicle from the telogen phase of the hair cycle to the anagen phase and increases the duration of the anagen phase, 25,26 leading to increased hair thickness due to dermal papillae enlargement. 27 Regarding dermoscopic findings in the present study, broken In the present study, vellus hair showed a significant increase in all groups.…”

Section: Discussionmentioning

confidence: 99%

Combined microneedling with topical vitamin D3 or bimatoprost versus microneedling alone in the treatment of alopecia areata: A comparative randomized trial

Ali

Hafiz

Ahmed

et al. 2023

J of Cosmetic Dermatology

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Introduction: Alopecia areata (AA) is a challenging disease with variable treatment outcomes. Hair follicles express vitamin D receptors. Therefore, vitamin D3 may be promising for AA treatment through immunomodulatory mechanisms. The efficacy of bimatoprost in scalp AA treatment was reported by few studies. Objective: To evaluate the efficacy and safety of microneedling (MN) with topical vitamin D3 versus MN with bimatoprost in comparison with MN alone in the treatment of localized AA. Patients and Methods: Seventy-five patients with localized AA were divided into three groups. The first group: 25 patients were treated with MN alone. The second group: 25 patients treated with MN combined with topical vitamin D3. The third group: 25 patients treated with MN combined with bimatoprost solution. The response was evaluated clinically and dermoscopically.Results: At the end of the study, all groups showed a statistically significant decrease in the SALT score compared to the baseline. The clinical response (regrowth scale): vitamin D and bimatoprost groups showed a statistically significant higher regrowth scale compared to MN alone group (p-value = 0.000). After treatment, hair regrowth was significantly higher in MN combined with bimatoprost than in MN combined with topical vitamin D3. However, after 3 months of follow-up, there was no statistically significant difference between both groups. Side effects were mild and transient in all groups. Conclusion:Topical vitamin D3 and bimatoprost combined with MN are safe and effective therapeutic options for localized AA.

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Section: Discussionmentioning

confidence: 99%

Combined microneedling with topical vitamin D3 or bimatoprost versus microneedling alone in the treatment of alopecia areata: A comparative randomized trial

Ali

Hafiz

Ahmed

et al. 2023

J of Cosmetic Dermatology

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“… 94 , 95 Some studies have assessed the drug in adult and pediatric patients, with variable results, which is probably due to conditions with different severities and, therefore, different AA prognoses. 96 It appears to be a safe and potentially effective agent for treating the region. It is important to note the risk of eyelid hyperpigmentation and darkening of the iris.…”

Section: Pre-treatment Considerationsmentioning

confidence: 99%

Consensus on the treatment of alopecia areata – Brazilian Society of Dermatology

Ramos¹,

Anzai²,

Duque‐Estrada³

et al. 2020

Anais Brasileiros de Dermatologia

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Background Alopecia areata is a highly frequent disease with an impact on quality of life and several treatment options with little clinical confirmatory evidence. Objective To disseminate the recommendations of Brazilian dermatologists with expertise in the treatment of alopecia areata. Methods Eight specialists with expertise in alopecia areata from different university centers were appointed by the Brazilian Society of Dermatology to reach a consensus on its treatment. Based on the adapted DELPHI methodology, the relevant elements were considered; then, an analysis of recent literature was carried out and the consensus was written down. Consensus on the management of alopecia areata was defined with the approval of at least 70% of the panel. Results/Conclusions Intralesional injectable corticotherapy was considered the first option for localized disease in adults. In extensive cases with signs of activity, systemic corticosteroid therapy should be considered and can be used together with immunosuppressants (corticosteroid-sparing agents). The use of an immunosensitizer (diphencyprone) is an option for stable long-term cases. Evaluation of side effects is as important as the rate of hair regrowth.

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“…The subgroup analysis of the dose was performed in each group ( Figure 5 ), with 0.05 mL of experimental group reagent in all four experimental groups ( 35 , 37 , 39 , 40 ), 0.25 mL of reagent in one experimental group ( 38 ), and 1.0 mL of reagent in one experimental group ( 36 ). The results showed that the dose of the 1.0 mL group had the largest effect size [SMD = 7.30, 95% CI (6.06, 8.54), p < 0.00001; Figure 5 ].…”

Section: Resultsmentioning

confidence: 99%

“…There was 1 study with unknown adverse reactions ( 36 ). The remaining studies ( 35 , 38 , 40 ) reported local adverse reactions to drug administration, including conjunctival hyperemia, punctate keratitis, erythema, folliculitis, the sensation of bilateral burning, and application site pruritus. There were also rare side effects reported by enrolled studies, such as urinary tract infections, other body hair increase, influenza and actinic keratosis.…”

Section: Resultsmentioning

confidence: 99%

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The efficacy of topical prostaglandin analogs for hair loss: A systematic review and meta-analysis

Jiang

Hao²,

Qi³

et al. 2023

Front. Med.

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BackgroundProstaglandin analogs have been found to have more versatile uses: treatment of open-angle glaucoma, high intraocular pressure, vitiligo, and other treatments. And prostaglandin analogs have been found to have an important role in the hair growth cycle. However, prostaglandin analogs have not been sufficiently studied for hair (including hair, eyelashes, and eyebrows) regeneration. In this study, a systematic review and meta-analysis of topical prostaglandin analogs on hair loss was performed.ObjectiveThe purpose of this meta-analysis is to determine the efficacy and safety of topical prostaglandin analogs for treating hair loss.MethodsWe searched PubMed, Embase, and Cochrane Library databases comprehensively. Data were pooled using Review Manager 5.4.1, and subgroup analyses were performed if necessary.ResultsThere were six randomized controlled trials included in this meta-analysis. All studies compared prostaglandin analogs with placebo, and one trial consisted of two sets of data. The results showed that prostaglandin analogs could significantly improve the hair length and density (p < 0.001). As far as adverse events are concerned, there was no significant difference between the experimental group and the control group.ConclusionIn patients with hair loss, the topical prostaglandin analogs have better therapeutic efficacy and safety than placebo. However, the best dose and frequency of experimental treatment require further studies.

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An evaluation of the safety and efficacy of bimatoprost for eyelash growth in pediatric subjects

Cited by 12 publications

References 18 publications

Combined microneedling with topical vitamin D3 or bimatoprost versus microneedling alone in the treatment of alopecia areata: A comparative randomized trial

Combined microneedling with topical vitamin D3 or bimatoprost versus microneedling alone in the treatment of alopecia areata: A comparative randomized trial

Consensus on the treatment of alopecia areata – Brazilian Society of Dermatology

The efficacy of topical prostaglandin analogs for hair loss: A systematic review and meta-analysis

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