An Evaluation of the Safety and Efficacy of Administering Rofecoxib for Postoperative Pain Management

Joshi, Wandana; Connelly, Neil Roy; Reuben, Scott S.; Wolckenhaar, Marten; Thakkar, Nikhil

doi:10.1213/01.ane.0000069507.93582.6e

Cited by 83 publications

(52 citation statements)

References 29 publications

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“…Children completed measures of pain, depression (CDI), and use of coping strategies (KidCope), and the primary caregiver completed the Brief Symptom Inventory (from which the depression subscale was used for the present study). Results of discriminant function analyses conducted separately for younger children (ages 7-12) and adolescents (13)(14)(15)(16)(17)(18) found that only the coping and caregiver depression variables significantly contributed to distinguishing clinical levels of depression in this sample. However, results varied by age: for younger children, caregiver depression was significantly more influential in distinguishing children who were versus who were not clinically depressed than child coping strategies.…”

Section: E32 Distinguishing Clinical Levels Of Depression In Childrenmentioning

confidence: 80%

“…In this study we investigated whether youth with disabilities could successfully use the NRS and we examined the relationships among different types of pain intensity ratings. 112 participants, aged [8][9][10][11][12][13][14][15][16][17][18][19][20]SD=1.24), were asked to use an 11-point NRS to rate their current pain, least, worst, and average pain over the past week. There were no significant differences by sex or disability in any of the four pain intensity ratings.…”

Section: G11 Measuring Pain In Youth With Disabilitiesmentioning

confidence: 99%

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Abstracts of the 7th International Symposium on Pediatric Pain

2006

Pain Research and Management

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Section: E32 Distinguishing Clinical Levels Of Depression In Childrenmentioning

confidence: 80%

Section: G11 Measuring Pain In Youth With Disabilitiesmentioning

confidence: 99%

Abstracts of the 7th International Symposium on Pediatric Pain

2006

Pain Research and Management

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“…Celecoxib was as effective as naproxen in children with juvenile rheumatoid arthritis (Foeldvari et al, 2008 Level II). Small-scale efficacy studies evaluated different perioperative doses of rofecoxib (prior to its withdrawal from the market): low dose (0.625 mg/kg) was inferior to ibuprofen (in combination with paracetamol) (Pickering et al, 2002 Level II); 1 mg/kg was superior to placebo (Joshi et al, 2003 …”

Section: Coxibsmentioning

confidence: 99%

Safety of opioid patch initiation in Australian residential aged care

Gadzhanova

Roughead

Pont

2015

Medical Journal of Australia

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Objective: To explore opioid use by aged care facility residents before and after initiation of transdermal opioid patches. Design: A cross‐sectional cohort study, analysing pharmacy data on individual patient supply between 1 July 2008 and 30 September 2013. Setting: Sixty residential aged care facilities in New South Wales. Participants: Residents receiving an initial opioid patch during the study period. Main outcome measure: The proportion of residents who were opioid‐naive in the 4 weeks prior to patch initiation was determined. In addition, the patch strength at initiation and the daily dose of transdermal patches and of additional opioids 1 month after initiation were determined. Results: An opioid patch was initiated in 596 of 5297 residents (11.3%: 2.6% fentanyl, 8.7% buprenorphine) in the 60 residential aged care facilities. The mean age at initiation was 87 years, and 74% of the recipients were women. The proportion of recipients who were opioid‐naive before patch initiation was 34% for fentanyl and 49% for buprenorphine. Most were initiated at the lowest available patch strength, and the dose was up‐titrated after initiation. Around 15% of fentanyl users and 10% of buprenorphine users needed additional regular opioids after patch initiation. Conclusions: The results suggest some inappropriate initiation of opioid patches in Australian residential aged care facilities. Contrary to best practice, a third of residents initiated on fentanyl patches were opioid‐naive in the 4 weeks before initiation.

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“…Anhand der Daten wurde errechnet, dass für 30-60 operierte Patienten eine zusätzliche Operation notwendig wird. Die Schlussfolgerungen der Autoren beider Metaanalysen waren nicht einheitlich: In einer Arbeit wurde zur Vorsicht geraten [106], in der anderen wurden von jeglichem -auch postoperativen -Einsatz von NSAID bei Tonsillektomien abgeraten [103].Bisher wurde in einer Studie der intraoperative Blutverlust bei Tonsillektomien nach Gabe von COX-2-Inhibitoren untersucht und kein erhöhter Verlust festgestellt [75].Nach derzeitigem Wissen ist es unwahrscheinlich, dass COX-2-Inhibitoren das Risiko für blutungsbedingte Reoperationen erhöhen -allerdings liegen hierzu bisher keine Daten vor.…”

Section: Darstellung Und Bewertung Der Studienlageunclassified

Nichtopioidanalgetika zur perioperativen Schmerztherapie

2004

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Non-opioid analgesics play a central role in the management of postoperative pain. In this review, the pharmacology, the analgesic efficacy and the side-effects of non-opioid analgesics are summarized. First, the pharmacology of diclofenac, acetyl salicylic acid, dipyrone, acetaminophen and the COX-2 inhibitors is described. Second, the analgesic efficacy of non-opioid analgesics is analyzed for moderate pain (e.g. ambulatory surgery) and for moderate to severe pain (e.g. abdominal surgery-in combination with opioids). There is limited evidence for an additive analgesic effect of two non-opioid analgesics. Third, the major side-effects of non-opioid analgesics are discussed in relation to the pathophysiology, the frequency and the clinical relevance of these effects. In particular, side-effects on the gastrointestinal tract (ulcus formation), on coagulation (bleeding and thrombosis), on the renal (renal insufficiency), the pulmonary (bronchospasm) and the hematopoetic systems (agranulocytosis) are described. Recommendations for the clinical use of non-opioid analgesics for perioperative pain therapy are given.

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An Evaluation of the Safety and Efficacy of Administering Rofecoxib for Postoperative Pain Management

Abstract: In children undergoing tonsillectomy, a single preoperative dose of rofecoxib decreases 2- and 24-h pain and decreases nausea and vomiting at home.

Cited by 83 publications

References 29 publications

Abstracts of the 7th International Symposium on Pediatric Pain

Abstracts of the 7th International Symposium on Pediatric Pain

Safety of opioid patch initiation in Australian residential aged care

Nichtopioidanalgetika zur perioperativen Schmerztherapie

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