An evaluation of the protective role of Ficus racemosa Linn. in streptozotocin-induced diabetic neuropathy with neurodegeneration

Solanki, Nilay; Bhavsar, Shailesh K.

doi:10.4103/0253-7613.169579

Cited by 25 publications

(16 citation statements)

References 27 publications

(30 reference statements)

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“…Behavioral markers (e.g., thermal hyperalgesia, cold allodynia, motor coordination and locomotor activity) were observed as evaluation parameters for diabetic neuropathy [46]. The treatment with GMT and pregabalin showed clear decline in withdrawal latency while compared with control animals (p < 0.01), which illustrate that there is deterioration of sensory motor reflux.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Dried Tubers of Aconitum napellus

Shoaib

Siddiqui

Dixit

et al. 2020

Plants

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The present study was designed to explore the neuroprotective properties of Aconitum napellus (Ranunculaceae). The plant detoxification was done using either water, or cow or goat milk as per the Ayurvedic shodhana method. The evaluation of the neuroprotective role of A. napellus was performed on diabetic neuropathy induced by streptozotocin in Sprague Dawley (SD) rats. Body mass, blood sugar level, oral glucose tolerance test, hyperalgesia, cold allodynia, motor co-ordination test, and locomotor activity, oxidative biomarkers (TBARS, reduced glutathione, catalase and superoxide dismutase) and sciatic nerve histomorphology were assessed. The in vitro studies were done on human neuroblastoma cell line SHSY-5Y and used an MTT assay to assess the antiproliferative activity of different extracts. Results suggest that the goat milk treated chloroform extract has less percentage of aconitine. After administration of the detoxified chloroform extract to the diabetic animals, there was a significant improvement in the myelination and degenerative changes of the nerve fibers along with behavioral changes (p < 0.05 as compared with diabetic control group). The findings of the in vitro research show an effective neuroprotective role of A. napellus. This suggests that A. napellus should be further investigated for its effect in diabetic pathology.

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Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Dried Tubers of Aconitum napellus

Shoaib

Siddiqui

Dixit

et al. 2020

Plants

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“…The antioxidant potentials of F. racemosa monitored in the significant elevation in catalase, superoxide dismutase, and amelioration of nitrite level, C-reactive protein and lipid peroxidation levels, which might be responsible for its potential antihyperalgesic activity. 88 Gymnemic acids, the active constituents in G. sylvestre, has proved to have antihyperalgesic activity in a preclinical model. The association of gymnemic acids antioxidant and antinflammatory activities might be responsible for its neuroprotective effects.…”

Section: Discussionmentioning

confidence: 99%

Neuropathic Pain: Literature Review and Recommendations of Potential Phytotherapies

Raafat¹,

El-Haj²,

Shoumar³

et al. 2017

Phcog J

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Introduction:One of the common syndromes that affect humanity is neuropathic pain (NP), yet poorly understood with no efficient treatment till now. Consequently, it is extremely crucial to seek further evidence for accurate diagnosis and optimum treatment. The aim of this work is to summarize the findings related to neuropathic pain in terms of etiology, types, diagnosis, current and future management prospective, and identify the gaps in neuropathic pain therapy. Methods: A literature investigation was carried out by analyzing classical peer reviewed papers and textbooks, taking into consideration worldwide well established scientific databases mainly PUBMED and SCOPUS to retrieve accessible published literature. The selection of phytotherapies was based upon their potentials in relieving NP in pre-clinical or clinical models. Results: One of the most critical points in this research is that recommendations of the future plans should be focused on the engagement of phytotherapy in the treatment regimen aiming at improving patients' quality of life and reaching optimum efficacy and minimum toxicity. Phytotherapies offer relatively low-risk options to NP patients and have an increasing evidence to be the future of neuropathic pain management. Patients suffering from neuropathy are depending increasingly on phytotherapies; however, they need more clinical trials in order to fully understand their mechanism of actions. Conclusion: Health-care specialists should be regularly informed about neuropathic pain current therapies and promising future phytotherapies, bearing in mind the risk/benefit profile of the utilization of these therapies in the amelioration of NP. Consistent with this criteria NP can be classified into "defined" (all criteria present), "probable" (I and II, in addition either III or IV) or "possible" (I and II, with no confirmatory tests). 3 Moreover, risk factors and epidemiology are cornerstones in understanding NP. Risk factors and EpidemiologyThe literature survey has shown fewer studies on the NP epidemiology. A study on patients evidenced neuropathic pain in 8.2% of adult patients having significantly higher pain intensity than others in a British study. 1,4 Moreover, in a randomly selected adult population using the Douleur Neuropathique four Questions, neuropathic pain were identified in 6.9% of the examined persons in a French study. 5 NP risk factors includes: females, elderly age, minor level of education, living in a rural area worse health (compromised physical, mental and social wellbeing). [5][6][7][8][9] Pathomechanisms Pathomechanisms causing the development of NP are divided into 3 groups: first, electrophysiological properties of the cellular membrane of the first Post-amputation Pain Phantom pain was incident in amputated patients with extremity and stump pain located surrounding the post-surgical stump scar. 31 Due to the fact that strong opiods, tramadol, gabapentin, lidocaine infusions, calcitonin pregabalin or amitriptyline are recommended, evidence of effectiveness ...

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“…Ficus racemosa (Moraceae) is widely used as herbal medicine in the prevention and treatment of diabetes and its complications which shows a significant decrease in glycosylated hemoglobin, blood glucose levels and improve body weight in diabetic animals. It has golden colored exudates and black bark shows protective effect as antioxidant, ant diabetic activities results in reversal of gluconeogenesis and may also be due to the improvement in insulin secretion and glycemic control [41]. Tinospora cordifolia (Menispermaceae)-is commonly known as guduchi.…”

Section: Ayurvedic Treatmentmentioning

confidence: 99%

Diabetic neuropathy: a focus on management

2020

Lett Appl NanoBioSci

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Diabetic neuropathy(DN) is a common troublesome ramification of diabetes mellitus impacting at least 50-60% patients of diabetes with multiple complication result in nerve damage, tingling, muscle wastage, sharp pains, burning and numbness in peripheral extremities more often experience pain in legs and feet. Hyperglycemia presents a central role in progression of DN that causes variations in the blood vessels providing blood to the peripheral nerves; metabolic diseases such as initiation of the polyol pathway, myo-inositol depletion, genetic deviations and elevated non-enzymatic glycation which causes the generation of free radicals or oxidative stress. Intense Glycemic control is vitalto the ultimate prevention of DN. Apart from allopathic treatments, there are various alternative treatments like herbal based therapies, acupuncture therapies and physiotherapies are used to improve pain and other symptoms of DN and its related complications. This review provides a summary of various therapies of DN for treatment and its management.

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An evaluation of the protective role of Ficus racemosa Linn. in streptozotocin-induced diabetic neuropathy with neurodegeneration

Cited by 25 publications

References 27 publications

Neuroprotective Effects of Dried Tubers of Aconitum napellus

Neuroprotective Effects of Dried Tubers of Aconitum napellus

Neuropathic Pain: Literature Review and Recommendations of Potential Phytotherapies

Diabetic neuropathy: a focus on management

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