An evaluation of the pharmacologic inhibition of the immediate and late cutaneous reaction to allergen

Smith, Joseph A.; Mansfield, Lyndon E.; Shazo, Richard de; Nelson, Harold S.

doi:10.1016/0091-6749(80)90195-5

Cited by 79 publications

(26 citation statements)

References 14 publications

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“…H 1-antagonists have been noted to inhibit late-phase allergic reac tions while H2-antagonists given alone had no effect [34][35][36]. When the two histamine antagonists were used in combination they potentiated the inhibitory effect of H 1 -antagonist.…”

Section: Discussionmentioning

confidence: 94%

Histamine Receptors on Leukocytes Are Expressed Differently in vitro and ex vivo

Leino¹,

Lilius²

1990

Int Arch Allergy Immunol

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The effect of histamine and histamine antagonists on the respiratory burst activity of leukocytes was studied. The activity was measured as zymosan-induced luminol-dependent chemiluminescence (CL) of isolated leukocytes and 1:2,500 diluted whole blood (WB). Histamine caused a dose-dependent inhibition of CL. For separated leukocytes the ID50 was 8 × 10^––5M and for WB it was 1.5 × 10^––3M. Diphenhydramine, an H1-antagonist increased the inhibitory effect of histamine while H2-antagonist cimetidine blocked the inhibition of CL of separated leukocytes. Cimetidine was not capable of reversing the effect of histamine on WB-CL. These data suggest that the histamine receptors on leukocytes are associated with Fc and/or complement receptors and the expression and function of histamine receptors can be studied by measuring the respiratory burst activity. The results also provide evidence of differences in histamine action in vitro and ex vivo conditions in WB.

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Section: Discussionmentioning

confidence: 94%

Histamine Receptors on Leukocytes Are Expressed Differently in vitro and ex vivo

Leino¹,

Lilius²

1990

Int Arch Allergy Immunol

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“…aneous weal and flare reactions evoked by allergen or compound 48/80 (Marks & Greaves, 1977;Johnson et al, 1984;Smith et al, 1980;Summers et al, 1981). Phillips et al (1983) examined the dose response relationships for H1-receptor inhibition of histamine (and allergen) induced cutaneous weal reactions by studying different concentrations of the H1-receptor antagonists administered intradermally.…”

Section: Resultsmentioning

confidence: 99%

The influence of ranitidine, alone and in combination with clemastine, on histamine‐mediated cutaneous weal and flare reactions in human skin.

Thomas¹,

Browne²,

Kirby³

1985

Brit J Clinical Pharma

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1 Significant, (P < 0.05) inhibition of histamine induced cutaneous weal and flare reactions by ranitidine at 10-5 M concentration has been demonstrated in a double blind, in vivo study; the results support the evidence for cutaneous H2-histamine receptors provided by previous studies using cimetidine and metiamide. 2 The degree of inhibition of histamine mediated cutaneous reactions achieved by clemastine was increased by the administration of clemastine and ranitidine together, for ranitidine concentrations 1075 M (P < 0.001) and 1076 M (P < 0.05).3 The magnitude of the inhibitory effect of ranitidine, both administered alone and in combination with clemastine, suggests that in the production of histamine induced cutaneous weal and flare reactions, the contribution afforded by stimulation of cutaneous H2-histamine receptors is only small.

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“…In humans, it was shown that the H1 antagonist, chlorphenylamine, significantly inhibited the immediate skin allergic reaction, but not the late skin reaction. Although cimetidine by itself had no effects on both immediate and late allergic reactions, this 1112 antagonist increased the inhibitory effect of the H1 antagonist on the allergic reaction and also completely blocked the late reaction when administered with H1 antagonist (Smith et al 1980). Cimetidine did not suppress the whealing reaction to histamine regardless of injective or oral administration (Hutchcroft et al 1979; Harvey and Shocket 1980; Nathan et al 1981).…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of histamine antagonists on the skin reaction with house dust allergen, histamine and compound 48/80 in Japanese monkeys.

Ohmi¹,

Mue²,

Tamura³

et al. 1983

Tohoku J. Exp. Med.

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An evaluation of the pharmacologic inhibition of the immediate and late cutaneous reaction to allergen

Cited by 79 publications

References 14 publications

Histamine Receptors on Leukocytes Are Expressed Differently in vitro and ex vivo

Histamine Receptors on Leukocytes Are Expressed Differently in vitro and ex vivo

The influence of ranitidine, alone and in combination with clemastine, on histamine‐mediated cutaneous weal and flare reactions in human skin.

Inhibitory effects of histamine antagonists on the skin reaction with house dust allergen, histamine and compound 48/80 in Japanese monkeys.

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