An evaluation of the male reproductive toxicity of cathinone

Islam, M. W.; Tariq, Mohammad; Ageel, A. M.; El‐Feraly, Farouk S.; Al-Meshal, I. A.; Ashraf, Ijaz

doi:10.1016/0300-483x(90)90145-7

Cited by 44 publications

(68 citation statements)

References 19 publications

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“…Studies in humans suggest decreased sperm motility and count in khat-chewing individuals but these studies lack a control sperm sample before khat administration [4,13]. Our data confirm previous findings in rats [24] showing a significant decrease in sperm count and motility in cathinone (the active ingredient of khat) treated animals in a dose-dependent manner (with an increasing dose producing the highest effect).…”

Section: Discussionsupporting

confidence: 82%

“…Such sperm abnormalities have also been demonstrated in infertile men with 30% of sperm from these patients having impaired DNA [16]. Similar observations of increased impaired sperm DNA have been reported in rats administered khat [24,25]. The mode of action of khat on sperm DNA remains to be established.…”

Section: Discussionsupporting

confidence: 62%

“…We speculate that khat has a dose-dependent effect on plasma testosterone levels. Indeed, in rats, both in vitro and in vivo studies showed that high concentrations of khat extract significantly inhibited testosterone production and caused degenerative changes in interstitial tissue and atrophy of Leydig and Sertoli cells, whereas low concentrations significantly stimulated testosterone production but had no effect on interstitial cell viability [6,24]. …”

Section: Discussionmentioning

confidence: 99%

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Short-Term Effects of High-Dose Khat on Sperm Parameters and Reproductive Hormonal Levels in Olive Baboons (Papio anubis)

Nyachieo

Kiraithe²,

Spiessens³

et al. 2012

Gynecol Obstet Invest

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The biological effects of khat (Catha edulis) on reproduction and fertility are inadequately investigated and controversial, hence we determined the effects of oral administration of high-dose khat on sperm parameters and male hormonal levels in olive baboons. In this study, 6 male baboons received a high dose of khat (500 g/week) during 1 month. Electroejaculation for sperm studies (concentration, motility and chromatin integrity) and plasma collection for hormonal analysis (testosterone, prolactin and cortisol) were done weekly during 1 month before and 1 month during khat administration as well as 2 weeks after the last dose of khat administration. Administration of khat extract induced a significant reduction in sperm motility (p = 0.008), sperm count (p = 0.041), sperm chromatin integrity (p = 0.0003), testosterone levels (p = 0.035) and prolactin levels (p = 0.0115), but not in cortisol levels and sperm volume (p > 0.05). The results suggest that high-dose khat decreases sperm quality and testosterone and hence may contribute to male infertility.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Short-Term Effects of High-Dose Khat on Sperm Parameters and Reproductive Hormonal Levels in Olive Baboons (Papio anubis)

Nyachieo

Kiraithe²,

Spiessens³

et al. 2012

Gynecol Obstet Invest

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show abstract

“…However, in rabbits fed khat for 3 months, there was an increased rate of spermatogenesis (Al-Mamary et al, 2002). This observation contrasts with the findings of Islam et al (1990) that animals receiving the active ingredient, cathinone, displayed degenerative changes in the testicular tissues.…”

Section: Risk Factors Associated With Khatcontrasting

confidence: 76%

Khat: pharmacological and medical aspects and its social use in Yemen

Al‐Motarreb

Baker

Broadley

2002

Phytotherapy Research

285

251

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Fresh leaves of the khat tree (Catha edulis Forsk.) are chewed for their euphoric properties in East Africa and parts of the Middle East, such as The Yemen. This review describes the history, cultivation and constituents of khat, and the social aspects of khat chewing in Yemen. The major pharmacologically active constituent of the fresh leaves is (--)-S-cathinone. The pharmacology of (--)-S-cathinone in the central nervous system and the peripheral effects are described. (--)-S-Cathinone is regarded as an amphetamine-like sympathomimetic amine and this mechanism of action is discussed in relation to the central stimulant actions and the cardiovascular effects of increasing blood pressure and heart rate. The risk factors associated with khat chewing are described, with emphasis on the reported increased incidence of acute myocardial infarction.

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“…In cathinonetreated rats, a significant decrease in sperm count and motility and an increase in the number of abnormal sperm cells were found (Islam et al 1990). The drug also produced a significant decrease in plasma testosterone levels.…”

Section: Other Effectsmentioning

confidence: 99%

Khat (Catha edulis) a contoversial plant: blessing or curse?

Bálint

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An evaluation of the male reproductive toxicity of cathinone

Cited by 44 publications

References 19 publications

Short-Term Effects of High-Dose Khat on Sperm Parameters and Reproductive Hormonal Levels in Olive Baboons <b><i>(Papio anubis)</i></b>

Short-Term Effects of High-Dose Khat on Sperm Parameters and Reproductive Hormonal Levels in Olive Baboons <b><i>(Papio anubis)</i></b>

Khat: pharmacological and medical aspects and its social use in Yemen

Khat (Catha edulis) a contoversial plant: blessing or curse?

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