An Evaluation of the Influence of Overweight on Blood Pressures of Healthy Men.

Haemodynamic Changes Associatedc with Obesity and High Blood Pressure in Crats with Ventromedial Hypothalamic Lesions

“…Practically every clinical epidemiological report has demonstrated that overweight is a major characteristic of hypertensive populations (Short & Johnson, 1939;Levy el al., 1946;Epstein et al, 1965;Kannel et al, 1967;Oberman et al, 1967;Johnson et af., 1975;Stamler et al, 1978) but there are differences in explanations of the haemodynamic changes. Some authors reported a high cardiac output associated with expanded intravascular volume (Alexander, 1963;Backman, Freyschuss, Hallberg & Melcher, 1973), but recently we showed that, despite the expanded intravascular volume, the fundamental relationship between systemic haemodynamic and intravascular volume remained unchanged and similar to that in other patients with essential hypertension (Messerli, Christie, de Carvalho, Aristimuno, Suarez, Dreslinski & Frohlich, 1980).…”

“…However, although a link exists between obesity and clinical hypertension (Short & Johnson, 1939 Johnson, Kjelsberg, Napier, Ostrander, Payne & Dodge, 1965;Kannel, Brand, Skinner, Dawber & McNamara, 1967;Oberman, Lane, Harlan, Graybiel & Mitchell, 1967;Johnson, Cornoni, Cassel, Tyroler, Hayden & Hames, 1975;Stamler, Stamler, Reidlinger, Algers & Roberts, 1978) and experimental hypertension (Koletsky, 1973(Koletsky, , 1975, the relationship of arterial pressure and other circulatory changes to ventromedial hypothalamic obese rats remains unclear. This report provides preliminary information with respect to these changes.…”

Rapid Weight Reduction: Loss of Three Hundred Pounds in Eighteen Months

“…She did well for three months, but her weight became stationary at approximately 200 pounds (90. 7 Kg.) after a loss of 279 pounds (126.5 Kg.).…”