An Evaluation of the Influence of Coronary Flow on Transcatheter Heart Valve Neo-Sinus Flow Stasis

Madukauwa-David, Immanuel David; Sadri, Vahid; Midha, Prem A.; Babaliaros, Vasilis; Aidun, Cyrus K.; Yoganathan, Ajit P.

doi:10.1007/s10439-019-02324-y

Cited by 20 publications

(22 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The explanation could be the higher coronary flow for WP60 that leads to a better washout. This finding would agree with a recent study on the impact of the coronary flow of the LCC 14 …”

Section: Discussionsupporting

confidence: 94%

“…A lower THV implant depth favors flow stasis in the neo‐sinus (the space between the native and the THV leaflets). This increases thrombosis severity 14,15 and enhances leaflet thrombosis 3,16‐18 found in as many as 40% of patients 16,18,19 . Latter reduces leaflet motion and worsens valve hemodynamics 14 .…”

Section: Introductionmentioning

confidence: 99%

“…This increases thrombosis severity 14,15 and enhances leaflet thrombosis 3,16‐18 found in as many as 40% of patients 16,18,19 . Latter reduces leaflet motion and worsens valve hemodynamics 14 . These findings have led to increased concerns of ischemic attacks, stroke, and long‐term valve durability 19,20 …”

Section: Introductionmentioning

confidence: 99%

“…Several previous in vitro studies were conducted to better understand the hemodynamics inside the native and/or neo sinus 11,12,21‐27 . However, these studies have several limitations including the use of a rigid aorta, 14,28 the absence of native leaflets and coronary flow 11,12,21,23,25,26,28 …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Hemodynamics inside the neo‐ and native sinus after TAVR: Effects of implant depth and cardiac output on flow field and coronary flow

Pott

Sedaghat²,

Schmitz

et al. 2020

Artificial Organs

View full text Add to dashboard Cite

Abstr act Transcatheter aortic valve replacement (TAVR) has emerged as a widely used therapy for aortic valve diseases. With TAVR, flow hemodynamics may change leading to areas of flow stagnation prone to thrombosis risk. The neo‐sinus, created by introducing a prosthesis inside the diseased native valve, may prompt leaflet thrombosis due to areas of flow stasis. This study attempted to understand the effect of different prosthesis implant depths on the flow field within the neo‐ and native sinus and on the coronary perfusion. Experiments were performed inside an in vitro pulse duplicator producing physiological conditions according to ISO 5840‐1:2015 standard. Flow fields were obtained for two cardiac outputs (CO) using particle image velocimetry (PIV). Washout was calculated as a measure of flow stasis. The two main results are: a lower implant position and a lower CO/frequency led to better native sinus washout, but worsened neo‐sinus washout. In contrast, a higher implant position led to higher coronary flow (for higher CO/frequency). No significant effect of implant depth on coronary flow was observed for lower CO/frequency. In summary, a higher implant position using this self‐expanding prosthesis is associated with reduced neo‐sinus flow stasis. Hereby, washout of the native sinus, as well as coronary flow, are dependent on cardiac output.

show abstract

“…The explanation could be the higher coronary flow for WP60 that leads to a better washout. This finding would agree with a recent study on the impact of the coronary flow of the LCC 14 …”

Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hemodynamics inside the neo‐ and native sinus after TAVR: Effects of implant depth and cardiac output on flow field and coronary flow

Pott

Sedaghat²,

Schmitz

et al. 2020

Artificial Organs

View full text Add to dashboard Cite

show abstract

“…The issue of SLT has been recognized as a complication after TAVI, and its incidence ranges from 0% to 40% [ 13 ]. This variability is partly justified by the lack of uniformity in the definition of SLT in the initial studies.…”

Section: Frequency Of Sltmentioning

confidence: 99%

The Issue of Subclinical Leaflet Thrombosis After Transcatheter Aortic Valve Implantation

et al. 2020

View full text Add to dashboard Cite

Transcatheter aortic valve implantation (TAVI) has been considered an important therapy for the treatment of symptomatic severe aortic stenosis. Although the devices and the techniques have been improved some complications may occur and several issues still need to be addressed. The issue of subclinical leaflet thrombosis (SLT) has been recognized as a complication after TAVI, and its incidence ranges from 0% to 40%. Nowadays, computed tomography is considered as the standard method for diagnosis of SLT. The concept of hypoattenuated leaflet thickening (HALT), reduced leaflet motion (RELM), and hypoattenuation affecting motion (HAM) have been used in this topic. Most patients who had SLT were taking single or dual antiplatelet therapy. In addition, these medications were not effective in resolving this complication after TAVI. However, there is a suggestion that oral anticoagulants have a protective and therapeutic effect. With the increasing use of TAVI, it is necessary to have better knowledge about several aspects of this complication, because it may have impact on prognosis. Therefore, some aspects of SLT diagnosis, management, and prognosis are not yet fully understood.

show abstract

Influence of Patient-Specific Characteristics on Transcatheter Heart Valve Neo-Sinus Flow: An In Silico Study

et al. 2020

View full text Add to dashboard Cite

An Evaluation of the Influence of Coronary Flow on Transcatheter Heart Valve Neo-Sinus Flow Stasis

Cited by 20 publications

References 27 publications

Hemodynamics inside the neo‐ and native sinus after TAVR: Effects of implant depth and cardiac output on flow field and coronary flow

Hemodynamics inside the neo‐ and native sinus after TAVR: Effects of implant depth and cardiac output on flow field and coronary flow

The Issue of Subclinical Leaflet Thrombosis After Transcatheter Aortic Valve Implantation

Influence of Patient-Specific Characteristics on Transcatheter Heart Valve Neo-Sinus Flow: An In Silico Study

Contact Info

Product

Resources

About