An Evaluation of the Hypoglycemic, Antioxidant and Hepatoprotective Potentials of Onion (Allium cepa L.) on Alloxan-induced Diabetic Rabbits

Ogunmodede, Oluwaseyi Samson; Saalu, L.C.; Ogunlade, Babatunde; Akunna, G.G.; Oyewopo, Adeoye Oyetunji

doi:10.3923/ijp.2012.21.29

Cited by 48 publications

(14 citation statements)

References 21 publications

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“…Many studies have pointed out onion as a source of multiple bioactive substances that are able to confer potential benefits on health and imbalances such as lipid alterations, inflammation and oxidative stress present in the initiation of most diseases [ 6 , 7 ]. The hepatoprotective effect of onion has been presented in diverse models of liver injury [ 8 , 9 ]. A recent study in experimental fed rats has revealed that onion consumption, as a part of a healthy diet, may be effective for some features in the management of NAFLD [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolomic Fingerprinting in the Comprehensive Study of Liver Changes Associated with Onion Supplementation in Hypercholesterolemic Wistar Rats

González-Peña

Dudzik

Garcı́a

et al. 2017

IJMS

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The consumption of functional ingredients has been suggested to be a complementary tool for the prevention and management of liver disease. In this light, processed onion can be considered as a source of multiple bioactive compounds with hepatoprotective properties. The liver fingerprint of male Wistar rats (n = 24) fed with three experimental diets (control (C), high-cholesterol (HC), and high-cholesterol enriched with onion (HCO) diets) was obtained through a non-targeted, multiplatform metabolomics approach to produce broad metabolite coverage. LC-MS, CE-MS and GC-MS results were subjected to univariate and multivariate analyses, providing a list of significant metabolites. All data were merged in order to figure out the most relevant metabolites that were modified by the onion ingredient. Several relevant metabolic changes and related metabolic pathways were found to be impacted by both HC and HCO diet. The model highlighted several metabolites (such as hydroxybutyryl carnitine and palmitoyl carnitine) modified by the HCO diet. These findings could suggest potential impairments in the energy−lipid metabolism, perturbations in the tricarboxylic acid cycle (TCA) cycle and β-oxidation modulated by the onion supplementation in the core of hepatic dysfunction. Metabolomics shows to be a valuable tool to evaluate the effects of complementary dietetic approaches directed to hepatic damage amelioration or non-alcoholic fatty liver disease (NAFLD) prevention.

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Section: Introductionmentioning

confidence: 99%

Metabolomic Fingerprinting in the Comprehensive Study of Liver Changes Associated with Onion Supplementation in Hypercholesterolemic Wistar Rats

González-Peña

Dudzik

Garcı́a

et al. 2017

IJMS

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“…Our results are in accordance with other studies (33,34) experimented on the blood glucose levels of broilers. Also, a reduction in blood glucose level in diabetic rats fed diets containing leek (Allium Ampeloprasum) for 1 month (5) and diabetic rabbits fed diets containing an aqueous extract of onions has been reported (48). The hypoglycemic effects of leek may be attributed to allyl-propyl-disulfide compounds present in it that compete with the insulin for metabolism, thus increasing the free insulin.…”

Section: Resultsmentioning

confidence: 99%

“…Other mechanisms postulated are sulfur-containing compounds, including dialkyl disulfides, and their oxidized thiols can trap electrons from the body to act as antioxidants or phenolic acids produced antioxidant activity (48,49). Furthermore, broilers fed on the diets containing LLE showed a significant (P = 0.001) decrease in serum levels of total cholesterol, triglyceride, and LDL and a significant (P = 0.001) increase in HDL levels compared with the control group (Table 5).…”

Section: Resultsmentioning

confidence: 99%

Effect of Egyptian Leek Leaf Extract Supplementation on Productive and Economic Performance of Broilers

et al. 2020

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Antibiotic growth promoters have been used to improve growth and feed conversion in the poultry industry for a long time; however, they were banned because of several life-threatening side effects in animals, poultry, and humans. This work was carried out to investigate the effect of leek (Allium ampeloprasum var. kurrat) leaf extract (LLE) as a non-traditional growth promoter and feed additive on growth performance, carcass characteristics, serum biochemical parameters, and economic efficiency of broilers. Hubbard unsexed 1-day-old broilers (n = 250) were fed with diets supplemented with LLE for 42 days. The experimental chicks were randomly assigned to one of the five treatment groups varying in LLE quantity in diets: 0% (control), 0.05, 0.1, 0.15, and 0.2%, with five replicates per treatment (50 chicks/treatment or 10 chicks/replicate). Results showed that LLE supplementation improved (P < 0.05) different growth performance parameters. Furthermore, dietary LLE not only decreased serum total cholesterol, triglyceride, low-density lipoprotein, and glucose levels but also increased serum high-density lipoprotein level compared to the control diet. The weight percentages of dressing (P = 0.022) and liver (P = 0.041) showed a marked increase after the addition of LLE. Return, net profit, and collective efficiency measures were increased (P = 0.001) in all LLE groups compared with the control group. Broilers that fed on diets containing 0.2% LLE showed the highest growth and economic efficiency. It could be concluded that supplementation with LLE in broilers has growth-promoting effects, improved biochemical parameters, carcass quality, and promoted economic efficiency through maximizing both return and net profit.

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“…Similarly, aqueous extract of A. cepa (100 and 300 mg/kg/day) caused hepato-protective effects by improvement of antioxidant parameters such as SOD, CAT, GPx, GSH and MDA in alloxan-induced diabetic rabbits (Ogunmodede et al. 2011 ).…”

Section: Methodsmentioning

confidence: 99%

A review of anti-inflammatory, antioxidant, and immunomodulatory effects of Allium cepa and its main constituents

Marefati

Ghorani

Shakeri

et al. 2021

Pharmaceutical Biology

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Context Allium cepa L. (Liliaceae), known as onion, is consumed throughout the world. Onion and its derivatives including saponins, aglycones, quercetin, cepaenes, flavonoids, organosulfurs, and phenolic compounds, showed various pharmacological properties and therapeutic effects. Objective Anti-inflammatory, antioxidant, and immunomodulatory effects of A. cepa and its main constituents, along with the underlying molecular mechanisms are presented. Methods Databases including, Web of Knowledge, Medline/PubMed, Scopus, and Google Scholar were checked for articles published between 1996 and the end of July 2020, using the key-words Allium cepa, quercetin, anti-inflammatory, antioxidant and immunomodulatory. Results A. cepa and its constituents mainly quercetin showed anti-inflammatory effects mediated via reduction of total and differential WBC counts, inhibition of chemotaxis of polymorphonuclear leukocytes, COX, and LOX pathways and prevented formation of leukotrienes and thromboxanes, prostaglandin E2 (PGE2) as onVCAM-1, NF-κB, MARK,d STAT-1, JNK, p38 and osteoclastogenesis. A. cepa and its derivatives showed antioxidant effect by decreasing lipid peroxidation, NAD(P)H, MDA, NO, LPO and eNOS but enhancing antioxidants such as SOD, CAT, GSH, GPx, GSPO, TrxR, SDH, GST and GR activities and thiol level. Immunomodulatory effects of the plant and quercetin was also shown by reduction of Th2 cytokines, IL-4, IL-5, and IL-13 as well as IL-6, IL-8, IL-10, IL-1β and TNF-α and IgE levels, but increased CD4 cells, IFN-γ level and IFN-γ/IL4 ratio (Th1/Th2 balance). Conclusions The effect of onion and its constituents on oxidative stress, inflammatory and immune system were shown indicating their therapeutic value in treatment of various diseases associated with oxidative stress, inflammation, and immune-dysregulation.

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An Evaluation of the Hypoglycemic, Antioxidant and Hepatoprotective Potentials of Onion (Allium cepa L.) on Alloxan-induced Diabetic Rabbits

Cited by 48 publications

References 21 publications

Metabolomic Fingerprinting in the Comprehensive Study of Liver Changes Associated with Onion Supplementation in Hypercholesterolemic Wistar Rats

Metabolomic Fingerprinting in the Comprehensive Study of Liver Changes Associated with Onion Supplementation in Hypercholesterolemic Wistar Rats

Effect of Egyptian Leek Leaf Extract Supplementation on Productive and Economic Performance of Broilers

A review of anti-inflammatory, antioxidant, and immunomodulatory effects of Allium cepa and its main constituents

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