An Evaluation of the Effects of Perioperatively Administered Fluids on Ischemia/Reperfusion Injury

Ozciftci, Serhat; Gamlı, Mehmet; Ornek, Dilsen; Horasanlı, Eyüp; Dikmen, Bayazıt; Canpolat, O; Mz, Ciraci; Kilci, Oya

doi:10.12669/pjms.316.7630

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“…Insufficient amount of fluid administration may result in reperfusion injury among multiple organs and tissues. [ 14 ] Compared to the young, the aged patients had increased blood viscosity and higher risk of reperfusion injury in organs after surgery. In addition, the elderly show reduced tolerance to anesthesia and intensified drug reactions especially when fluids are administrated under less-than-normal blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Preoperative fluid management in traumatic shock

Lou¹,

Zhao

et al. 2018

Medicine

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Fluid resuscitation was used on aged patients with traumatic shock in their early postoperative recovery. The present study aimed to assess whether different fluid resuscitation strategies had an influence on aged patients with traumatic shock.A total of 219 patients with traumatic shock were recruited retrospectively. Lactated Ringer and hydroxyethyl starch solution were transfused for fluid resuscitation before definite hemorrhagic surgery. Subjects were divided into 3 groups: group A: 72 patients were given aggressive fluid infusion at 20 to 30 mL/min to restore normal mean arterial pressure (MAP) of 65 to 75 mm Hg. Group B: 72 patients were slowly given restrictive hypotensive fluid infusion at 4 to 5 mL/min to maintain MAP of 50 to 65 mm Hg. Group C: 75 patients were given personalized infusion to achieve MAP of 75 to 85 mm Hg. Preoperative infusion volume, preoperative MAP, optimal initial points for surgery, postoperative shock time and mortality rates at 6 and 24 hours after surgery were determined.No significant difference in clinical characteristics was found among the 3 groups. Amount of preoperative infusion was considerably lower in the restrictive group (P < .01, compared with group A). A significant difference in preoperative infusion volume was found between the personalized and other 2 groups (P < .01, compared with groups A and B). Patients in the personalized resuscitation group achieved a higher preoperative MAP (P < .01 compared with Group B; P < .05, compared with group A) and required less prepared time for surgery (P < .01 compared with groups A and B). In addition, a lower mortality rate at 6 and 24 hours after operation was observed in the subjects with personalized therapy (P < .05, compared with group B).Personalized management of fluid resuscitation in traumatized aged patients with appropriate volume and speed of fluid transfusion, suggesting increased survival rate and less prepared time for surgery.

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Section: Discussionmentioning

confidence: 99%