“…Results predominantly favorable in respect to prolonged survival and decreased morbidity have been reported from use of coumarin anticoagulants in these diseases. [1][2][3][4] However, there has not been adequate evaluation of the ease or difficulty with which a satisfactory and practical program of prolonged anticoagulant therapy can be carried out. The purpose of this paper is to evaluate this aspect of anticoagulant therapy in ambulatory patients with vascular and thromboembolic diseases who have been observed during the past 101½2 years.…”