An Evaluation of the Carcinogenic Potential of Five Man-Made Vitreous Fibers Using the Intraperitoneal Test

Lambré, Claude; Schorsch, Frédéric; Blanchard, Olivier; Richard, Jean-Louis; Boivin, Jean-Francois; Hanton, D.; Grimm, H; Morscheidt, C.

doi:10.1080/089583798197321

Cited by 10 publications

(9 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Petersen and Sabroe (1991) showed that MMVF was a significant cause of irritation of the eyes, skin and upper respiratory tract for Swedish construction workers. Twothirds of those working daily with mineral wool reported frequent symptoms of irritation, and Lambre´et al (1998) found that rats exposed to certain stone-wool fibres exhibited a significant dose-related occurrence of cancer. Schmeitz (2001) also suggested that the embodied energy of sheep-wool is smaller than that of equivalent MMVF materials by a factor of 5-8.…”

Section: Introductionmentioning

confidence: 98%

Thermal conductivity of wool and wool-hemp insulation

Wells

Carrington

et al. 2005

Int. J. Energy Res.

View full text Add to dashboard Cite

SUMMARYMeasurements have been obtained for the thermal resistance of sheep-wool insulation and wool-hemp mixtures, both in the form of bonded insulation batts, using a calibrated guarded hot-box. The density was 9.6-25.9 kg m À3 for the wool and 9.9-18.1 kg m À3 for the wool-hemp mixtures. The measurements were made at a mean sample temperature of 13.38C using a calibrated guarded hot-box. The estimated uncertainly in the resistance measurements was of the order of AE 7%. The thermal conductivity of the samples, derived from the thermal resistance measurements on the basis of the measured thickness, was well correlated with the density, although the variation with density was larger than that obtained in previous studies. The conductivity of the wool-hemp samples was not significantly different from that of the wool samples at the same density. Moisture uptake produced an increase of less than 5% in the conductivity of the bonded wool insulation for an increase in absorbed moisture content of 20%. The thermal resistance was 1.6% lower on average for samples oriented in the horizontal plane rather than the vertical plane, but this difference is not significant.

show abstract

Section: Introductionmentioning

confidence: 98%

Thermal conductivity of wool and wool-hemp insulation

Wells

Carrington

et al. 2005

Int. J. Energy Res.

View full text Add to dashboard Cite

show abstract

“…Results from the previous chronic intra-peritoneal (IP) study were reported by (Lambre et al, 1998). This earlier study was designed in 1990 with the start of exposure in December 1991.…”

Section: The Previous Studymentioning

confidence: 94%

“…A subsequent study by Roller et al (1996) reported similar results. This fiber type was therefore used in the Lambre study as an internal comparison, however, the results were not published by Lambre et al (1998) due to the commercial competitive situation at that time. As this situation has since changed, they are now included in Table 1.…”

Section: The Previous Studymentioning

confidence: 99%

Experience From a Long-Term Carcinogenicity Study With Intraperitoneal Injection of Biosoluble Synthetic Mineral Fibers

Grimm¹,

Bernstein²,

Attia³

et al. 2002

Inhalation Toxicology

View full text Add to dashboard Cite

The carcinogenic potential in the intraperitoneal cavity of three newly developed biosoluble insulation glass wool fibers (M, P, and V) and one newly developed biosoluble insulation stone wool fiber (O) was investigated and compared to that of a previously developed soluble glass fiber (B). The in vitro dissolution coefficient of the three glass wool fibers ranged from 450 to 1037 ng/cm(2) x h and was 523 ng/cm(2) x h for the stone wool fiber. The in vitro dissolution coefficient of the B fiber was 580 ng/cm(2) x h. Groups of female Wistar rats (strain Crl: Wi BR) were exposed by repeated injections to doses of 0.5, 2, and 5 x 10(9) WHO fibers, which corresponds to between 41 mg to 724 mg fiber injected. In addition, 2 groups of crocidolite were used as positive controls at doses of 0.1 x 10(9) and 1 x 10(9) WHO fibers (0.5 and 5 mg). The in vitro dissolution coefficient of crocidolite is estimated to be approximately 1 ng/cm(2) x h. The protocol of the study and the size distribution of the test samples conformed to the European Commission Protocol EUR 18748 EN, and the study was executed under Good Laboratory Practice conditions. Two of the new insulation wools, fibers M and 0, showed no statistically significant tumorigenic response even at the very high dose of 5 x 10(9) WHO fibers injected. Fibers P and V showed a small tumorigenic response in the ip cavity similar in magnitude to the B fiber, which has been declared in the German fiber regulations as a noncarcinogenic fiber. The response to the soluble insulation fibers was notably different from that of the known carcinogen crocidolite, which produced 53% tumors at a comparatively low dose of 0.1 x 10(9) WHO fibers. The incidence of mesothelioma was found to be highly correlated to the incidence of intra-abdominal nodules and masses at different sites. The incidence of abdominal nodules and masses was highly correlated to the number of animals with ascites. The incidence of chronic peritonitis with fibrotic nodules at different organs also correlated with the incidence of mesotheliomas. Differences in etiology were observed between the massive doses of the highly soluble insulation wools when injected directly into the ip cavity and the lower doses of the extremely insoluble fiber crocidolite. The variability in this reaction and the impairment of animal health put into question the value of these massive doses in evaluating the carcinogenic response of soluble insulation wools. All of the fibers tested fulfilled the exoneration criteria with respect to carcinogenicity according to the European Directive 97/69/EC ("an appropriate intra-peritoneal test has not expressed signs of excessive carcinogenicity"). The dose as defined in the EC-Protocol EUR 18748 EN was 1 x 10(9) WHO fibers with a defined geometric spectrum. The influence of fiber dimensions on the ip tumor response and the difficulty in assessing the influence of the difference in background levels between this and previous studies make direct application of the German TRGS 905 criteria difficult;...

show abstract

“…Exposure route (and species) Test materials Principal end points studied Bellmann et al (1995) Intra-tracheal instillation (rat) Stone wools Lung burden/fibre retention; fibre length and diameter distributions; fibre half life Bernstein et al (1996) Inhalation biopersistence test (rat) Glass wools; rock/stone wools; AES wool Lung burden/fibre retention; fibre length and diameter distributions; fibre half-life Hesterberg et al (1998) Chronic inhalation (rat) AES (X607) wool; RCF/ASW; chrysotile Lung burden; pulmonary pathology Lambre et al (1998) Intra-peritoneal injection (rat) Glass wools; stone wools; crocidolite Carcinogenic potential (mesothelium) Kamstrup et al (2001) Chronic inhalation ( following instillation also has to be tested. 5 The detailed composition, maximum use temperatures and other properties of the AES wools are subject to continuous development; details are available from the manufacturers.…”

Section: Authormentioning

confidence: 99%

“…It was concluded from this study that X607 is not persistent in the lung and hence causes minimal pulmonary toxicity. Lambre et al (1998) evaluated the potential carcinogenic hazard of five man-made vitreous fibres using intraperitoneal injection in the rat. The fibres used in this study, designated A, C, F, G and H, were glass wools (sodium-modified borosilicates; A, C) or stone wools (calcium modified silicates; F, G and H) and were all considered to be 'new-generation' insulation wool fibres with higher solubility than the commercial fibres in use at that time.…”

Section: The Development and Testing Of Less Biopersistent High Tempementioning

confidence: 99%