An evaluation of the bioaccessibility of arsenic in corn and rice samples based on cloud point extraction and hydride generation coupled to atomic fluorescence spectrometry

Rosas-Castor, J.M.; Portugal, Lindomar A.; Ferrer, Laura; Hinojosa‐Reyes, Laura; Guzmán-Mar, Jorge Luis; Hernández-Ramírez, Aracely; Cerdà, Vı́ctor

doi:10.1016/j.foodchem.2016.02.149

Cited by 31 publications

(3 citation statements)

References 44 publications

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“…This might be associated with the increasing viscosity from SLNS1 (∼10 –3 Pa·s) to SLNS4 (∼10 0 Pa·s). It is commonly believed that liquid samples with higher viscosity would be more “sticky” on the devices inner wall and more difficult to aerosolize, resulting in a greater residue . Thus, the loaded sample should not be highly viscous (e.g., 10 1 Pa·s or higher) to minimize the residue.…”

Section: Resultsmentioning

confidence: 99%

Endotracheal Aerosolization Device for Laboratory Investigation of Pulmonary Delivery of Nanoparticle Suspensions: In Vitro and in Vivo Validation

Huang

et al. 2018

Mol. Pharmaceutics

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The objective of this study was to perform the in vitro and in vivo validation of an endotracheal aerosolization (ETA) device (HRH MAG-4, HM). Solid lipid nanoparticle suspension (SLNS) formulations with particle sizes of approximately 120, 240, 360, and 480 nm were selected as model nanoparticle suspensions for the validation. The emission rate (ER) of the in vitro aerosolization and the influence of aerosolization on the physicochemical properties were investigated. A high ER of up to 90% was obtained, and no significant alterations in physicochemical properties were observed after the aerosolization. The pulmonary deposition of model drug budesonide in Sprague−Dawley rats was determined to be approximately 80%, which was satisfactory for pulmonary delivery. Additionally, a fluorescent probe with aggregation-caused quenching property was encapsulated in SLNS formulations for in vivo bioimaging, after excluding the effect of aerosolization on its fluorescence spectrum. It was verified that SLNS formulations were deposited in the lung region. The results demonstrated the feasibility and reliability of the HM device for ETA in laboratory investigation.

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Section: Resultsmentioning

confidence: 99%

Endotracheal Aerosolization Device for Laboratory Investigation of Pulmonary Delivery of Nanoparticle Suspensions: In Vitro and in Vivo Validation

Huang

et al. 2018

Mol. Pharmaceutics

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“…Cloud point extraction of metal ions requires complexation of metal ions with a suitable ligand. For example, ligands such as ammonium pyrrolidinedithiocarbamate [6][7][8] and O,O-diethyldithiophosphate [9][10][11] were used in CPE for As (III). For binding of As (V), ammonium molybdate, [12][13][14] acridine orange in combination with tartaric acid, [15] Pyronine B, [16,17] 2',7'dichlorofluorescein [18] were proposed.…”

Section: Introductionmentioning

confidence: 99%

Determination of Arsenic by ICP‐OES after Cloud Point Extraction with Salt Induced Phase Separation: Application to Gadolinium Based MRI Contrast Agent**

et al. 2022

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A new separation and preconcentration procedure based on cloud point extraction was developed for arsenic trace analysis using inductively coupled plasma optical emission spectrometry. Arsenic in + 5 oxidation state was complexed with ammonium molybdate, Triton X-100 was used as a surfactant. Optimal parameters such as pH value and Triton X-100 concentration were determined. Phase separation was induced by adding a salting-out agent to avoid an analyte loss because of temperature changes. The combination of Triton X-100 with ammonium sulphate as a salting-out agent was firstly sug-gested as an extraction system for arsenic quantification. Conditions for arsenic (III) into arsenic (V) oxidation were established. The proposed procedure was successfully applied for arsenic quantification in a gadolinium based magnetic resonance imaging (MRI) contrast agent gadobutrol at the level indicated in the guideline for elemental impurities approved by International council for harmonisation of technical requirements for pharmaceuticals for human use (ICH Q3D) as a limit concentration.

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“…Response surface methodologies (RSM) are multivariate optimization techniques, which allow for the finding of the critical conditions of the factors (maxima or minima) through the establishment of quadratic models [26]. Doehlert Matrix is one of the RSM that is often employed for optimization of analytical strategies [27,28]. This design has advantages compared to the other RSM because it allows for the obtaining of quadratic models, in which the number of levels of the factors is different, it has good efficiency, and also its matrix does not contemplate experiments with all factors in the positive or negative levels [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Multivariate optimization of a procedure employing microwave-assisted digestion for the determination of nickel and vanadium in crude oil by ICP OES

Anjos

Alves

Soares

et al. 2018

Talanta

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This work presents the optimization of a sample preparation procedure using microwave-assisted digestion for the determination of nickel and vanadium in crude oil employing inductively coupled plasma optical emission spectrometry (ICP OES). The optimization step was performed utilizing a two-level full factorial design involving the following factors: concentrated nitric acid and hydrogen peroxide volumes, and microwave-assisted digestion temperature. Nickel and vanadium concentrations were used as responses. Additionally, a multiple response based on the normalization of the concentrations by the highest values was built to establish a compromise condition between the two analytes. A Doehlert matrix optimized the instrumental conditions of the ICP OE spectrometer. In this design, the plasma robustness was used as chemometric response. The experiments were performed using a digested oil sample solution doped with magnesium(II) ions, as well as a standard magnesium solution. The optimized method allows for the determination of nickel and vanadium with quantification limits of 0.79 and 0.20μgg, respectively, for a digested sample mass of 0.1g. The precision (expressed as relative standard deviations) was determined using five replicates of two oil samples and the results obtained were 1.63% and 3.67% for nickel and 0.42% and 4.64% for vanadium. Bismuth and yttrium were also tested as internal standards, and the results demonstrate that yttrium allows for a better precision for the method. The accuracy was confirmed by the analysis of the certified reference material trace element in fuel oil (CRM NIST 1634c). The proposed method was applied for the determination of nickel and vanadium in five crude oil samples from Brazilian Basins. The metal concentrations found varied from 7.30 to 33.21μgg for nickel and from 0.63 to 19.42μgg for vanadium.

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An evaluation of the bioaccessibility of arsenic in corn and rice samples based on cloud point extraction and hydride generation coupled to atomic fluorescence spectrometry

Cited by 31 publications

References 44 publications

Endotracheal Aerosolization Device for Laboratory Investigation of Pulmonary Delivery of Nanoparticle Suspensions: In Vitro and in Vivo Validation

Endotracheal Aerosolization Device for Laboratory Investigation of Pulmonary Delivery of Nanoparticle Suspensions: In Vitro and in Vivo Validation

Determination of Arsenic by ICP‐OES after Cloud Point Extraction with Salt Induced Phase Separation: Application to Gadolinium Based MRI Contrast Agent**

Multivariate optimization of a procedure employing microwave-assisted digestion for the determination of nickel and vanadium in crude oil by ICP OES

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