An evaluation of the antioxidant and antiviral action of extracts of rosemary and provençal herbs

Aruoma, Okezie I.; Spencer, Jeremy P.E.; Rossi, Ruggero; Aeschbach, Robert; Khan, Adil I.; Mahmood, Naheed; Muñoz, Antonio; Murcia, A; Butler, J. A. V.; Halliwell, Barry

doi:10.1016/0278-6915(96)00004-x

Cited by 257 publications

(171 citation statements)

References 29 publications

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“…(7) Carnosol and carnosic acid have been shown to be responsible for 90% of the antioxidant activity found in rosemary. (6,8) In traditional Chinese medicine rosemary extracts are given orally that contain high amounts of diterpenes and triterpenes have been used to treat inflammatory conditions. Additionally, a variety of dietary supplements of rosemary extracts are available that have been standardized to carnosol and/or carnosic acid.…”

Section: Introductionmentioning

confidence: 99%

Carnosol, a Dietary Diterpene, Displays Growth Inhibitory Effects in Human Prostate Cancer PC3 Cells Leading to G2-Phase Cell Cycle Arrest and Targets the 5′-AMP-Activated Protein Kinase (AMPK) Pathway

et al. 2008

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Purpose-The anti-cancer effect of carnosol was investigated in human prostate cancer PC3 cells.Methods-Biochemical analysis and protein array data of carnosol treated PC3 cells were analyzed.Results-We evaluated carnosol for its potential anti-cancer properties in the PC3 cells. Using an MTT assay we found that carnosol (10 -70 µM) decreases cell viability in a time and dose dependent manner. Next, we evaluated the effect of carnosol (20-60 uM) effect using flow cytometry as well as biochemical analysis and found induction of G2-phase cell cycle arrest. To establish a more precise mechanism, we performed a protein array that evaluated 638 proteins involved in cell signaling pathways. The protein array identified 5'-AMP-activated protein kinase (AMPK), a serine/threonine protein kinase involved in the regulation of cellular energy balance as a potential target. Further downstream effects consistent with cancer inhibition included the modulation of the mTOR/HSP70S6k/4E-BP1 pathway. Additionally, we found that carnosol targeted the PI3K/Akt pathway in a dose dependent manner.Conclusions-These results suggest that carnosol targets multiple signaling pathways that include the AMPK pathway. The ability of carnosol to inhibit prostate cancer in vitro suggests carnosol may be a novel agent for the management of PCa.

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Section: Introductionmentioning

confidence: 99%

Carnosol, a Dietary Diterpene, Displays Growth Inhibitory Effects in Human Prostate Cancer PC3 Cells Leading to G2-Phase Cell Cycle Arrest and Targets the 5′-AMP-Activated Protein Kinase (AMPK) Pathway

et al. 2008

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“…1). Four polyphenol components isolated from rosemary ( Aruoma et al, 1996). The leaves of rosemary possess a variety of bioactivities, including anti-inflammatory activity (Altinier et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Screening of Mammalian DNA Polymerase Inhibitors from Rosemary Leaves and Analysis of the Anti-inflammatory and Antiallergic Effects of the Isolated Compounds

Mizushina

Onodera

Kuriyama

et al. 2014

FSTR

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In this study, on screening mammalian DNA polymerase (pol) inhibitors from the extracts of 20 edible plants, we found that leaves of rosemary (Rosmarinus officinalis L.) showed the strongest pol inhibition; furthermore, we isolated four components, carnosic acid, carnosol, ursolic acid, and rosmarinic acid, from an extract of the leaves.Carnosic acid inhibited the activities of all 11 mammalian pols tested. In descending order of their inhibitory effect on pol λ, which is a DNA repair/recombination pol, the four compounds ranked as follows: carnosic acid > ursolic acid > carnosol > rosmarinic acid. The inhibition of pol λ by these compounds was significantly correlated with both in vivo anti-inflammatory and antiallergic effects, including on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory mouse ear edema, and immunoglobulin E-induced passive cutaneous anaphylactic reaction in mice.These results indicate that rosemary and its constituent, carnosic acid, are potential therapeutic food candidates for inflammatory and allergic diseases.

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“…The greatest level of attention among herbs and spices as sources of antioxidants has been focused on rosemary [4]. Rosemary (Rosmarinus officinalis L.) is a perennial herb from Lamiaceae family, typical of the Mediterranean region, which has been believed have many potential biological and pharmacology functions, such as antioxidant, antimicrobial, hepatoprotective and antiproliferative [5][6][7][8][9]. Therefore, in this study, we investigate whether rosemary extract has the capacity to prolong the lifespan of D. melanogaster and its underlying molecular mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Rosemary Extract Mediated Lifespan Extension in Drosophila Melanogaster

Wang¹,

Zhang²,

Sun³

et al. 2016

Proceedings of the 2015 International Conference on Materials Chemistry and Environmental Protection (Meep-15)

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Abstract-Rosemary (Rosmarinus officinalis L.) has always known a versatile, aromatic herb and addition to being used as a food flavoring is also known medicinally for its powerful antioxidant activity, antibacterial and hepatoprotective properties. In this study we examined the effects of rosemary iextract on the lifespan and aging in Drosophila melanogaster against high-fat induced oxidative injury, and found that it responded to rosemary extract with an increased lifespan and reduced MDA content during aging. We found that lifespan extension by rosemary extract was attributed to its increasing the activity of SOD, CAT and decreasing the content of MDA. Moreover, Realtime-PCR analysis showed that the gene expression of SOD, and CAT was enhanced, in contrast MTH was significantly reduced. In conclusion, these results suggest that the antioxidant and antiaging effect of rosemary extract may, at least in part, be due to its interactions with endogenous antioxidant protective enzymes including SOD and CAT.

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An evaluation of the antioxidant and antiviral action of extracts of rosemary and provençal herbs

Cited by 257 publications

References 29 publications

Carnosol, a Dietary Diterpene, Displays Growth Inhibitory Effects in Human Prostate Cancer PC3 Cells Leading to G2-Phase Cell Cycle Arrest and Targets the 5′-AMP-Activated Protein Kinase (AMPK) Pathway

Carnosol, a Dietary Diterpene, Displays Growth Inhibitory Effects in Human Prostate Cancer PC3 Cells Leading to G2-Phase Cell Cycle Arrest and Targets the 5′-AMP-Activated Protein Kinase (AMPK) Pathway

Screening of Mammalian DNA Polymerase Inhibitors from Rosemary Leaves and Analysis of the Anti-inflammatory and Antiallergic Effects of the Isolated Compounds

Rosemary Extract Mediated Lifespan Extension in Drosophila Melanogaster

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