An Evaluation of the Ability of Priscoline, Regitine, and Roniacol to Overcome Vasospasm in Normal Man

Green, Harold D.; Göbel, Werner; Moore, Michael J.; Prince, Thomas C.

doi:10.1161/01.cir.6.4.520

Cited by 11 publications

(4 citation statements)

References 3 publications

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“…No doubt the vasodilatation involved other tissues too, as suggested by the feeling of a stuffed nose by all of the subjects (cf. Green et al [6]). However, during forearm exercise the forearm blood flow and vascular resistance were not influenced by phentolamine.…”

Section: Haemodynamic Effectsmentioning

confidence: 99%

Haemodynamic and Metabolic Effects of α-Adrenoceptor Blockade with Phentolamine at Rest and during Forearm Exercise

Hartling

Trap‐Jensen

1983

Clinical Science

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The pre- and post-junctional alpha-adrenoceptor blocking agent, phentolamine, was given by intravenous infusion to eight healthy volunteers during rest, forearm exercise and post-exercise. Phentolamine produced a sustained increase in heart rate. The diastolic blood pressure decreased slightly whereas systolic and mean blood pressures remained unchanged. Phentolamine caused a marked increase in the forearm blood flow and a decrease in vascular resistance at rest and post-exercise, but did not influence the blood flow or vascular resistance in the exercising forearm. There was a small increase in arterial blood glucose concentration, and a decrease in blood alanine concentration during drug infusion. Blood lactate was not affected by phentolamine. The arterial concentrations of free fatty acids and glycerol increased, and the concentration of triglycerides decreased during phentolamine infusion. Forearm exchange of glucose, lactate, alanine, glycerol, free fatty acids, triglycerides and forearm oxygen consumption were not changed significantly. These findings corroborate the concept that alpha-adrenoceptor induced vasoconstriction plays a subordinate role in exercising skeletal muscle. All of the metabolic findings might be explained as secondary to an increased noradrenaline release during phentolamine infusion.

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Section: Haemodynamic Effectsmentioning

confidence: 99%

Haemodynamic and Metabolic Effects of α-Adrenoceptor Blockade with Phentolamine at Rest and during Forearm Exercise

Hartling

Trap‐Jensen

1983

Clinical Science

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“…Drugs were infused intravenously at a more or less constant rate in 0-85 % sodium chloride solution. Phentolamine, an a-blocker (Roberts, Richardson & Green, 1952;Green, Gobel, Moore & Prince, 1952;Green, 1957), was given a total dose of 30-40 mg over about 20-30 min, during the last 10 min of which the adrenaline was also given. Two ,8blockers were used; the first five subjects received 70-S80 mg of pronethalol (Dornhorst & Robinson, 1962;Black & Stephenson, 1962), and the remaining four subjects about 10 mg of propranalol (Black, Crowther, Shanks, Smith & Dornhorst, 1964), in each case over about 10 min immediately preceding the infusion of adrenaline.…”

Section: Introductionmentioning

confidence: 99%

The rise in clotting factor VIII induced in man by adrenaline: effect of α‐ and β‐blockers

Ingram¹,

Jones²

1966

The Journal of Physiology

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SUMMARY1. Human subjects received intravenous infusions of adrenaline preceded by saline, phentolamine (an a-blocker) or either pronethalol or propranalol (fl-blockers), in different experiments.2. Clinical measurements of blood pressure and pulse rate confirmed that oc-or ,-blockade had been achieved.3. The rise in clotting factor VIII induced by adrenaline was blocked by pronethalol and propranalol but not by phentolamine. This indicated that the effect of adrenaline on factor VIII was mediated by f-receptors.

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“…Kinmonth & Hadfield (120) have advocated preganglionic sympathetic section in preference to ganglionectomy in the treatment o(jRaynaud's disease. Green et al (121) and Green & Grimsley (122) have studied antiadrenergic drugs and find Regitine active in vasospasm and arteriosclerotic disease.…”

Section: Peripheral Vascular Diseasementioning

confidence: 99%

Diseases of the Cardiovascular System

Graham¹,

Maxwell²

1954

Annu. Rev. Med.

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CORONARY ARTERIAL DISEASEExogenous cholesterol metabolism in man has been studied by Biggs et al.(1) using tritium-labeled cholesterol. Ingested cholesterol was demon strated in an atherosclerotic aorta. Severe hypercholesterolemia was pro duced in rats by Page & Brown (2), intimal lipid infiltration occurring but atherosclerosis failed to develop. A sustained low blood cholesterol level has been obtained in man by Pollak (3) using sitosterol in oral dosage of 5 to 10 gm. per day. Paterson (4) consider � the precipitating factor in coronary artery occlusion of capillary rupture within the atherosclerotic plaques is more important than the degree of atherosclerosis.The early assessment of coronary artery insufficiency is of importance. Master et al. (5) give criteria of electrocardiographic changes following their exercise test which they consider to be more significant than the resting elec trocardiogram. Ischemic electrocardiographic changes comparable with those following exercise have been demonstrated by Contro et al. (6) after amyl nitrite inhalation, and the use of this as a simple functional test is suggested.Attention has been drawn by Papp & Smith (7) to the clinical entity of slight cardiac infarction. Cardiac pain, angina of effort, and a variable degree of shock and failure occur, but laboratory and clinical signs are minimal. The pathological lesions correspond to small areas of infarction which repre sent the acute stage of patchy myocardial sclerosis resulting from arterio sclerotic narrowing of the main coronary arteries and not from a local ar terial occlusion. Clinical recovery occurs in a high proportion of these cases. Q waves were absent in one-half of this group of patients and R-T changes were of the subacute type. Changes were found mainly in leads III R and aVFr, exercise being useful in demonstrating ischemia. Severe cases of posterior infarction had a mortality of 33 per cent; the prognosis in the moderate group was good. Elek et al. (8) have found the left back leads of value in diagnosis.High posterolateral infarction of the anatomical left surface of the heart has been the subject of an interesting study by Tulloch (9). Diagnostic signs of infarction are found in VL and lead 1. A predominant R wave is found in VI, with absence of a definite transitional zone in the precordial leads, a high upright T wave in two or more of these, and in the acute stage, S-T depression. Additional back leads are useful.Electrocardiographic and pathologic changes following infarction of the 1 The survey of literature pertaining to this review covers the period from July. 1952 to June, 1953. 51 Annu. Rev. Med. 1954.5:51-66. Downloaded from www.annualreviews.org Access provided by McGill University on 02/05/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS

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An Evaluation of the Ability of Priscoline, Regitine, and Roniacol to Overcome Vasospasm in Normal Man

Cited by 11 publications

References 3 publications

Haemodynamic and Metabolic Effects of α-Adrenoceptor Blockade with Phentolamine at Rest and during Forearm Exercise

Haemodynamic and Metabolic Effects of α-Adrenoceptor Blockade with Phentolamine at Rest and during Forearm Exercise

The rise in clotting factor VIII induced in man by adrenaline: effect of α‐ and β‐blockers

Diseases of the Cardiovascular System

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