An evaluation of the ability of the peripheral vasodilator buflomedil to improve vascular patency after acute frostbite

Daum, Patricia; Bowers, Wildert D.; Tejada, Jorge; Morehouse, David H.; Hamlet, Murray P.

doi:10.1016/0011-2240(89)90036-9

Cited by 18 publications

(9 citation statements)

References 11 publications

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“…Several pharmacological strategies have been attempted to reduce the microcirculatory insufficiency and oedema induced by cold injury. Free radical scavengers ( Maity et al ., 1992 ), adrenocortical extracts ( Serda & Wei, 1991 ), non‐steroidal anti‐inflammatory drugs ( Talwar & Gulati, 1972 ), anti‐coagulative ( Webster & Bonn, 1965 ), fibrinolytic ( Zdeblick et al ., 1988 ), sympatholytic ( Snider & Porter, 1975 ), vasodilatator ( Daum et al ., 1989 ) and antihistamine agents ( Cummings & Lykke, 1973 ) have been used to improve tissue survival. Most studies on cold injuries have been performed on animals and have shown minimal improvement in tissue survival ( Britt et al ., 1991 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of α‐trinositol on interstitial fluid pressure, oedema generation and albumin extravasation in experimental frostbite in the rat

Berg

Aas

Gustafsson

et al. 1999

British J Pharmacology

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1 The anti-in¯ammatory eect of a-trinositol (D-myo-inositol-1,2,6-trisphosphate) on oedema formation, microvascular protein leakage and interstitial¯uid pressure (P if ) in rat skin after frostbite injury, was investigated. a-Trinositol (40 mg kg body weight 71 ) was administered intravenously as a bolus both before and/or in the interval between freezing and thawing of the tissue. 2 P if was measured in rat paw skin with micropipettes connected to a servo-controlled counterpressure system. Oedema formation was estimated by measuring the increase in total tissue water content (wet weight minus dry weight divided by dry weight). Albumin extravasation (i.e., the dierence between the plasma equivalent space for 125 I-and 131 I-human serum albumin (HSA) circulating for dierent time intervals) was used to estimate the microvascular leakage. 3 Compared to untreated animals, a-trinositol given pre-and/or post-freeze reduced total tissue water and albumin extravasation as well as the fall in P if in injured tissue signi®cantly (P50.05). aTrinositol given only post-freeze reduced total tissue water and albumin extravasation from 4.46+0.93 and 2.37+1.12 to 2.51+0.29 and 0.36+0.18 ml g dry weight 71 , respectively (P50.05). 4 P if fell from 70.8+0.2 mmHg pre-freeze to 73.4+1.0 mmHg (P50.05) at 20 min after tissue injury (circulatory arrest) and was attenuated by treatment with a-trinositol. 5 We conclude that a-trinositol exerts its anti-oedematous eect by acting on the extracellular matrix, attenuating the lowering of P if as well as on the microvascular wall, thereby decreasing the protein extravasation.

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Section: Introductionmentioning

confidence: 99%

Effect of α‐trinositol on interstitial fluid pressure, oedema generation and albumin extravasation in experimental frostbite in the rat

Berg

Aas

Gustafsson

et al. 1999

British J Pharmacology

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“…Vasodilators, such as prostaglandin E 1 (PGE 1 ), 49 the prostacyclin analog iloprost, 50,51 nitroglycerin, 42 pentoxifylline, 52,53 phenoxybenzamine, nifedipine, reserpine, 54,55 and buflomedil, 47 ,56,57 have been used as primary and adjunctive therapies in the treatment of frostbite injuries. In addition to vasodilatation, some of these agents may also prevent platelet aggregation and microvascular occlusion that occur after frostbite.…”

Section: Immediate Medical Therapy—hospital (Or High-level Field Clinic)mentioning

confidence: 99%

“…49 Buflomedil is an alpha-adrenolytic agent that is used widely in Europe with some preliminary and anecdotal evidence of good results 47,57 ; however, animal models have not replicated these findings. 56 In addition, the medication is not approved by the US Food and Drug Administration. Intraarterial reserpine has been studied in a case control study and found not to be effective.…”

Section: Immediate Medical Therapy—hospital (Or High-level Field Clinic)mentioning

confidence: 99%

Wilderness Medical Society Practice Guidelines for the Prevention and Treatment of Frostbite: 2014 Update

McIntosh¹,

Opacic

Freer

et al. 2014

Wilderness & Environmental Medicine

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The Wilderness Medical Society convened an expert panel to develop a set of evidence-based guidelines for the prevention and treatment of frostbite. We present a review of pertinent pathophysiology. We then discuss primary and secondary prevention measures and therapeutic management. Recommendations are made regarding each treatment and its role in management. These recommendations are graded on the basis of the quality of supporting evidence and balance between the benefits and risks or burdens for each modality according to methodology stipulated by the American College of Chest Physicians. This is an updated version of the original guidelines published in

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“…50 Buflomedil is an alpha adrenolytic agent that is used widely in Europe with some preliminary and anecdotal evidence of good results; 48,58 however, animal models have not replicated these findings. 57 In addition, the medication is not approved by the Food and Drug Administration in the United States. Intra-arterial reserpine has been studied in a case control study and found not to be effective.…”

Section: Immediate Medical Therapy-hospital (Or High Level Field Clinic)mentioning

confidence: 99%

“…Vasodilator therapy Vasodilators, such as prostaglandin E1 (PGE1), 50 the prostacyclin analogue iloprost, 51,52 nitroglycerin, 43 pentoxifylline, 53,54 phenoxybenzamine, nifedipine, reserpine, 55,56 and buflomedil 48 ,57,58 have been used as primary and adjunctive therapies in the treatment of frostbite injuries. In addition to vasodilatation, some of these agents may also prevent platelet aggregation and microvascular occlusion that occur after frostbite.…”

Section: Immediate Medical Therapy—hospital (Or High Level Field Clinic)mentioning

confidence: 99%

Wilderness Medical Society Practice Guidelines for the Prevention and Treatment of Frostbite

McIntosh

Hamonko

Freer

et al. 2011

Wilderness & Environmental Medicine

101

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The Wilderness Medical Society convened an expert panel to develop a set of evidence-based guidelines for the prevention and treatment of frostbite. We present a review of pertinent pathophysiology. We then discuss primary and secondary prevention measures and therapeutic management. Recommendations are made regarding each treatment and its role in management. These recommendations are graded based on the quality of supporting evidence and balance between the benefits and risks/burdens for each modality according to methodology stipulated by the American College of Chest Physicians.

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An evaluation of the ability of the peripheral vasodilator buflomedil to improve vascular patency after acute frostbite

Cited by 18 publications

References 11 publications

Effect of α‐trinositol on interstitial fluid pressure, oedema generation and albumin extravasation in experimental frostbite in the rat

Effect of α‐trinositol on interstitial fluid pressure, oedema generation and albumin extravasation in experimental frostbite in the rat

Wilderness Medical Society Practice Guidelines for the Prevention and Treatment of Frostbite: 2014 Update

Wilderness Medical Society Practice Guidelines for the Prevention and Treatment of Frostbite

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