“…Several pharmacological strategies have been attempted to reduce the microcirculatory insufficiency and oedema induced by cold injury. Free radical scavengers ( Maity et al ., 1992 ), adrenocortical extracts ( Serda & Wei, 1991 ), non‐steroidal anti‐inflammatory drugs ( Talwar & Gulati, 1972 ), anti‐coagulative ( Webster & Bonn, 1965 ), fibrinolytic ( Zdeblick et al ., 1988 ), sympatholytic ( Snider & Porter, 1975 ), vasodilatator ( Daum et al ., 1989 ) and antihistamine agents ( Cummings & Lykke, 1973 ) have been used to improve tissue survival. Most studies on cold injuries have been performed on animals and have shown minimal improvement in tissue survival ( Britt et al ., 1991 ).…”