An Evaluation of Serum Procalcitonin and C-Reactive Protein Levels as Diagnostic and Prognostic Biomarkers of Severe Sepsis

Szederjesi, János; Almasy, Emoke; Lazăr, Alexandra; Huţanu, Adina; Badea, Iudita; Georgescu, Anca Meda

doi:10.1515/jccm-2015-0022

Cited by 19 publications

(16 citation statements)

References 24 publications

(23 reference statements)

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“…Recently, multiple biomarkers have been studied. A study performed on septic patients underlined the fact that even though C-reactive protein and procalcitonin levels are not useful in diagnosing severe sepsis, they can be used in order to predict the fatal progression of this disorder [27]. Soluble urokinase-type plasminogen activator receptor (suPAR) is another important biomarker that seems have a predictive capacity for bacteremia in sepsis, even though it appears to be an independent factor for mortality prognosis in septic patients [28].…”

Section: Discussionmentioning

confidence: 99%

Staphylococcal Scalded Skin Syndrome in Child. A Case Report and a Review from Literature

Grama

Mărginean

Meliţ

et al. 2016

The Journal of Critical Care Medicine

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Staphylococcal scalded skin syndrome (SSSS) is the medical term used to define a skin condition induced by the exfoliative toxins produced by Staphylococcus aureus. The disorder is also known as Ritter disease, bullous impetigo, neonatal pemphigus, or staphylococcal scarlet fever. The disease especially affects infants and small children, but has also been described in adults. Prompt therapy with proper antibiotics and supportive treatment has led to a decrease in the mortality rate. The current case report describes the clinical progress of a patient with generalized erythema and fever, followed by the appearance of bullous lesions with tendency to rupture under the smallest pressure, and with extended areas of denudation. The patient aged four years and six months was admitted to our clinic to establish the aetiology and treatment of a generalized bullous exanthema, followed by a skin denudation associated with fever and impaired general status. Based on clinical and paraclinical examinations a diagnosis of Staphylococcal scalded skin syndrome was established which responded favourably to antibiotic treatment, hydro-electrolytic re-equilibration, and adequate local hygiene. Staphylococcal infection can represent a problem of significant pathological importance sometimes requiring a multidisciplinary approach involving paediatricians, dermatologists, infectious diseases specialists, and plastic surgeons.

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Section: Discussionmentioning

confidence: 99%

Staphylococcal Scalded Skin Syndrome in Child. A Case Report and a Review from Literature

Grama

Mărginean

Meliţ

et al. 2016

The Journal of Critical Care Medicine

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“…In recent years, the idea of sepsis biomarkers which can aid early diagnosis and the susceptibility of individuals has been established. However, none has the specificity necessary for the exclusive use, and it is currently accepted that a diagnosis of sepsis requires the identification of serum BM panels [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Relevance of Coding Gene Polymorphysms of Cytokines and Cellular Receptors in Sepsis

Georgescu

Grigorescu

Chirteș

et al. 2017

The Journal of Critical Care Medicine

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Sepsis is an injurious systemic host response to infection, which can often lead to septic shock and death. Recently, the immune-pathogenesis and genomics of sepsis have become a research topic focusing on the establishment of diagnostic and prognostic biomarkers. As yet, none have been identified as having the necessary specificity to be used independently of other factors in this respect. However the accumulation of current evidence regarding genetic variations, especially the single nucleotide polymorphisms (SNPs) of cytokines and other innate immunity determinants, partially explains the susceptibility and individual differences of patients with regard to the evolution of sepsis. This article outlines the role of genetic variation of some serum proteins which have the potential to be used as biomarker values in evaluating sepsis susceptibility and the progression of the condition.

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“…PCT is released by the solid tissue cells of liver and peripheral blood mononuclear cellsduring microbial infection.But Liver failure may lead to the formation ofa network of monocytes to reduce theconcentration of acute-phase proteins (APPs) [32]. The more severe the underlying liver dysfunction, the lower the CRP response to bacteremia [33].JJanos Szederjesi et al reported there was no signi cant correlation between the levels of the PCT and CRP biomarkers and severe sepsis .Quantitive procalcitonin and C-reactive protein analysis was not shown to be useful in diagnosing severe sepsis [34].Our data showed that levels of CRP and PCT in liver cirrhosis patients with sepsis did not increase signi cantly (Table 2), even though they were signi cantly different between the non-sepsis group and sepsis group.…”

Section: Discussionmentioning

confidence: 99%

Value of serum sTREM-1,D-lactate and I-FABP in diagnosis and prognosis evaluation in liver cirrhotic patients with sepsis

Yang

Zhang

Wang

et al. 2020

Preprint

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BackgroundSepsis is can cause serious negative effects among patients with cirrhosis.Finding reliable biomarker in early diagnose and prognosis in septic patients with liver cirrhosis is very important.We assessed value of serumsoluble triggering receptor expressed on myeloid cells-1 ( sTREM-1),D-lactate and Intestinal fatty acid binding protein(I-FABP) in diagnosis and prognosis evaluation in liver cirrhotic patients with sepsis.MethodsA prospective observational study of 158 cirrhosis patients was conducted. A total of 158cirrhosis patients were enrolled, 83 of whom were diagnosed with sepsis and 75 patients without sepsis during hospitalization.We evaluated value of early diagnostic and prognosis of cells-1(sTREM-1),D-lactate and I-FABP in cirrhotic patients with sepsis.Receiver operating characteristic curves (ROCs) were used to assess the ability of tested biomarkers to diagnose and prognosis cirrhotic patients with sepsis.ResultsOur results showed the CRP，PCT，sTREM-1, D-lactate and I-FABP were significantly higher in the sepsis group than in the no-sepsis group.,but only levels of serum sTREM-1 showed increasing trend with the severity of the cirrhotic patients with sepsis. The cutoff value of sTREM-1was 123.62 pg/mL and showed 84.3% sensitivity and 92.0% specificity and high accuracy in the early diagnosis for cirrhotic patients with sepsis.The AUC of sTREM-1 was 0.959(95%CI: 0.934–0. 985) and higher than that of CRP,PCT,D-lactate and I-FABP( P <0.001, P =0.002, P <0.001, P <0.001 respectively).Total 31(37.35%) cirrhotic patients with sepsis cases died during 90-day follow-up.Only sTREM-1 level had significance between survivors and non-survivors(263.99±213.79 vs 672.24±191.44,P=0.031).The AUCs of sTREM-1 for predicting 90-day mortality was 0.904( 95% CI:0.836-.971 ) and higher than that of CRP,PCT,D-lactate (P=0.001,p=0.003, P <0.001 respectively) The AUCs of I-FABP is only 0.482 and had no value of predicting prognosis.ConclusionSerum sTREM-1 is a valuable new biomarker for early diagnosis and prognosis in cirrhosis with sepsis, proving more accurate than CRP,PCT, D - lactate and I - FABP.Serum D-lactate and I-FABP levels can identify early cirrhosis with sepsis, but they is little relationship with the prognosis of patients.

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An Evaluation of Serum Procalcitonin and C-Reactive Protein Levels as Diagnostic and Prognostic Biomarkers of Severe Sepsis

Cited by 19 publications

References 24 publications

Staphylococcal Scalded Skin Syndrome in Child. A Case Report and a Review from Literature

Staphylococcal Scalded Skin Syndrome in Child. A Case Report and a Review from Literature

The Relevance of Coding Gene Polymorphysms of Cytokines and Cellular Receptors in Sepsis

Value of serum sTREM-1,D-lactate and I-FABP in diagnosis and prognosis evaluation in liver cirrhotic patients with sepsis

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