An evaluation of sensorimotor integration during locomotion toward a target in Parkinson’s disease

Almeida, Quincy J.; Frank, James S.; Roy, Éric; Jenkins, Mary E.; Spaulding, Sandi J.; Patla, Aftab E.; Jog, Mandar

doi:10.1016/j.neuroscience.2005.02.050

Cited by 100 publications

(102 citation statements)

References 25 publications

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“…These findings support the results found in previous studies investigating sensorimotor deficits in PD (Adamovich et al, 2001;Almeida et al, 2005), but importantly highlight that self-motion deficits are present even with vision of the environment. There are a number of potential explanations for the greater movement errors that were seen during the walking condition.…”

Section: Perception Of Distance With and Without Movementsupporting

confidence: 91%

“…First, proprioceptive processing of the upper limbs has been found to be impaired in PD (Keijsers et al, 2005;Klockgether et al, 1995;Rickards & Cody, 1997;Zia et al, 2000). When investigating PD movements (i.e., pointing or walking) in complete darkness, thus relying solely on proprioceptive information, previous studies have found reliable error in PD similar to what was seen in the current study and have concluded that these errors were a result of proprioceptive deficits (Almeida et al, 2005;Jacobs & Horak, 2006;Keijsers et al, 2005;Mongeon et al, 2009). A second possibility may be that, as has been demonstrated in previous research (Adamovich et al, 2001), visual-proprioceptive integration is impaired in PD.…”

Section: Perception Of Distance With and Without Movementsupporting

confidence: 76%

“…suggesting that an underlying proprioceptive deficit or visual proprioceptive integration may be responsible for movement impairments commonly seen in PD (Almeida et al, 2005). Utilizing the different sensory conditions for estimating distance, impairments in processing visual information about distance, as well as processing visual motion information about moving through an environment were ruled out, since differences between those with PD and healthy control participants were not found.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, movement impairments might be anticipated in PD as a consequence of poor proprioceptive processing. One study in particular investigated the influence of visual and proprioceptive information in locomotion and target accuracy in PD (Almeida et al, 2005). Results showed that when PD patients performed the task 'off' their medication, they moved to the target (in the dark) with less accuracy than healthy control participants and demonstrated the most difficulty when proprioception was the primary source of feedback.…”

Section: List Of Tablesmentioning

confidence: 99%

“…There has been some evidence that dopaminergic medication makes proprioceptive processing worse in PD (O'Suilleabhain et al, 2001), however conflicting evidence has shown no difference between 'ON' and 'OFF' states (Almeida et al, 2005). In an effort to clarify the role of dopaminergic medication in sensory cue processing, the current study tested all PD participants both 'ON' and 'OFF' dopaminergic medication across sensory cue conditions.…”

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confidence: 96%

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Dopaminergic contributions to distance estimation in Parkinson's disease: A sensory-perceptual deficit?

2013

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Section: Perception Of Distance With and Without Movementsupporting

confidence: 91%

Section: Perception Of Distance With and Without Movementsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: List Of Tablesmentioning

confidence: 99%

mentioning

confidence: 96%

See 3 more Smart Citations

Dopaminergic contributions to distance estimation in Parkinson's disease: A sensory-perceptual deficit?

2013

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Genetic susceptibility of lung cancer associated with common variants in the 3′ untranslated regions of the adenosine triphosphate‐binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export

Wang

Jin

Wang

et al. 2009

Cancer

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Although Parkinson's disease (PD) is traditionally considered a motor output disorder, recent evidence suggests that people with PD may have sensory and perceptual impairments that may underlie movement impairments. Yet there has not been any direct testing of perceptual judgments, especially when manipulating the sensory feedback on which these judgments are made. The present study investigated how perception might be influenced by sensory feedback to contribute to height estimations and obstacle stepping in PD relative to healthy age‐matched control participants. Perceptual judgment accuracy was evaluated by judging 3 typically encountered obstacle heights in 2 sensory feedback conditions: (1) vision of foot available and (2) without vision of foot (reliance on proprioceptive feedback to estimate height). Then participants proceeded to walk and step over the obstacle. Fifteen individuals with PD and 15 healthy control participants completed the task. As seen with toe elevation, toe elevation variability, and toe error measures, individuals with PD overestimated the obstacle height and were significantly more variable when relying solely on proprioception (in contrast to when vision was available) compared with healthy controls, although no differences between groups in obstacle crossing were found. These results support the notion that sensory deficits may contribute to inaccuracy of perceptual judgment and has the potential to contribute to gait behaviors such as tripping and falling, especially when vision is not available. Future studies should carefully consider the impact of sensory and perceptual deficits that might contribute to movement planning problems and consequentially movement impairments. © 2011 Movement Disorder Society

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Dopaminergic modulation of timing control and variability in the gait of Parkinson's disease

et al. 2007

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The basal ganglia have been implicated in timing control, yet the nature of timing disturbances in Parkinson's disease (PD) is poorly understood. We evaluated the influence of timing cues on spatiotemporal aspects of gait control and its variability, and the impact of dopaminergic treatment on timing. Three separate groups: 19 PD (OFF state); 24 PD (ON state); and 30 control participants were tested. Participants walked on a computerized carpet at four randomized and metronome-controlled rates: self-paced, 60, 80, or 100 steps/min. To our knowledge, this is the first study to demonstrate that medicated PD patients had poorer timing control than patients withdrawn from medication and healthy participants when modulating timing to an external stimulus. Increased step-to-step timing variability and deficits in mean temporal gait characteristics revealed that the medicated PD group (in contrast to nonmedicated PD group) performed least like healthy participants. This was observable in externally-cued conditions, but not during self-paced gait. Similar to previous research, step length contributed to overall slowness in PD, while temporal characteristics of gait did not. Interestingly, healthy participants increased stride length with each increase in cue rate, whereas both PD groups locked their step length regardless of temporal demand. Step-to-step variability differences between PD and healthy (e.g. step and double-support time measurements) may be indicative of specific basal ganglia involvement in temporal control of gait.

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An evaluation of sensorimotor integration during locomotion toward a target in Parkinson’s disease

Cited by 100 publications

References 25 publications

Dopaminergic contributions to distance estimation in Parkinson's disease: A sensory-perceptual deficit?

Dopaminergic contributions to distance estimation in Parkinson's disease: A sensory-perceptual deficit?

Genetic susceptibility of lung cancer associated with common variants in the 3′ untranslated regions of the adenosine triphosphate‐binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export

Dopaminergic modulation of timing control and variability in the gait of Parkinson's disease

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