An evaluation of qH NMR: A complementary approach to GC-FID for quantification of Thymol and trans-Anethole in essential oils and supplements

Reyhani, Yekta; Iranshahi, Mehrdad; Taghizadeh, Seyedeh Faezeh; Saberi, Satar; Farhadi, Faegheh

doi:10.1016/j.jpba.2022.114992

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…[23][24][25][26][27] Regarding the quantitative determination of components in essential oils, the first attempts date back to 1980 and concerned the quantitation of carvone in caraway and dill oils (60 MHz spectrometer). 28 Since that time, a few studies have been reported concerning 1 H NMR quantitative determination of some components of essential oils: sesquiterpene hydrocarbons and benzyl benzoates (Brickellia veronicaefolia) 29 ; trans-anethole (fennel) 30 ; α-pinene (Eucalyptus and Corymbia species, Schinus terebinthifolius, turpentine) 31 ; α-bisabolol (Eremanthus erythropappus) 32 ; menthofuran (Mentha aquatica) 33 ; geraniol, citronellol and citronellal (Cymbopogon species) 34 ; thymol and trans-anethole (Foeniculum vulgare and Zataria multiflora) 35 ; and thermolabile chemical markers (Curcuma caesia). 36 A comparative study of quantification of methyleugenol in foods concluded that GC-MS is suited for regulatory purposes but is time-consuming and NMR can be used for a faster screening analysis.…”

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A fast and reliable method to quantify neral and geranial (citral) in essential oils using ¹H NMR spectroscopy

Paoli,

Maroselli,

Casanova

et al. 2023

Flavour & Fragrance J

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Citral (3,7‐dimethyl‐2,6‐octadienal), a mixture of geranial and neral (two stereoisomeric monoterpene aldehydes), is considered an important raw material in the fields of fragrance, pharmaceutical, food and cosmetic industries. It is a well‐known biologically active compound present in various essential oils. A fast and reliable experimental method was developed and validated in order to quantify citral in essential oils using 1H NMR spectroscopy (experiment time at the minute level). The quantitative procedure, using anisole as internal standard, showed a perfect linearity of measurements (R2 = 0.9999), a very good accuracy (relative errors comprised between −1.9% and 0.3%) and an excellent precision (reproducibility 17.8 mg ± 1.0%). The procedure was also checked with three mixtures of weighted monoterpenes and the contents of citral, measured by GC and 1H NMR, were absolutely comparable. Then, the method was successfully applied to measure the contents of citral in 10 commercially available essential oils. Among the investigated samples, citral varied from 2.9% (Zingiber officinalis) to 90.6% (Bakhousia citriodora).

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confidence: 99%

A fast and reliable method to quantify neral and geranial (citral) in essential oils using ¹H NMR spectroscopy

Paoli,

Maroselli,

Casanova

et al. 2023

Flavour & Fragrance J

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Quantification of Two Sulfide Compounds in Oleo–Gum‐Resin Supplement of Ferula foetida Using qH NMR and GC–MS Methods

Eghbali,

Iranshahi,

Rezaee

et al. 2024

Flavour & Fragrance J

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Asafoetida is an oleo–gum‐resin mainly obtained from Ferula foetida in eastern Iran, which is employed for the treatment of stomachaches, acid reflux, nervous system disorders and respiratory diseases. Asafoetida has attracted the attention of researchers due to its sulfide compounds and their proven effects on respiratory illnesses. In this study, the shelf stability of supplement of F. foetida's oleo–gum‐resin by quantifying two key sulfide compounds including E/Z‐sec‐butyl propenyl disulfane and E/Z‐(methylthio)propyl 1‐propenyl disulfane was evaluated by 1H NMR (qH NMR) and gas chromatography–mass spectrometry (GC–MS). The similar results were obtained in both qH NMR and GC–MS methods. The qH NMR method showed good linearity in the ranges of 2–12 mg/mL for E/Z‐sec‐butyl propenyl disulfane and 2.2–17 mg/mL for E/Z‐(methylthio) propyl 1‐propenyl disulfane with a correlation coefficient of 0.99 and acceptable stability (RSD% ≤ 2.72%) for the quantification of the compounds. Therefore, despite the volatility of disulfide compounds and according to the results, the qH NMR method could be considered adequate method for quantifying these compounds in supplements containing the volatile components that requires extra extraction steps before analyses by other method.

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An overview of analytical methods employed for quality assessment of Crocus sativus (saffron)

Eghbali,

Farhadi,

Askari

2023

Food Chemistry: X

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An evaluation of qH NMR: A complementary approach to GC-FID for quantification of Thymol and trans-Anethole in essential oils and supplements

Cited by 4 publications

References 30 publications

A fast and reliable method to quantify neral and geranial (citral) in essential oils using ¹H NMR spectroscopy

A fast and reliable method to quantify neral and geranial (citral) in essential oils using ¹H NMR spectroscopy

Quantification of Two Sulfide Compounds in Oleo–Gum‐Resin Supplement of Ferula foetida Using qH NMR and GC–MS Methods

An overview of analytical methods employed for quality assessment of Crocus sativus (saffron)

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An evaluation of qH NMR: A complementary approach to GC-FID for quantification of Thymol and trans-Anethole in essential oils and supplements

Cited by 4 publications

References 30 publications

A fast and reliable method to quantify neral and geranial (citral) in essential oils using 1H NMR spectroscopy

A fast and reliable method to quantify neral and geranial (citral) in essential oils using 1H NMR spectroscopy

Quantification of Two Sulfide Compounds in Oleo–Gum‐Resin Supplement of Ferula foetida Using qH NMR and GC–MS Methods

An overview of analytical methods employed for quality assessment of Crocus sativus (saffron)

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A fast and reliable method to quantify neral and geranial (citral) in essential oils using ¹H NMR spectroscopy

A fast and reliable method to quantify neral and geranial (citral) in essential oils using ¹H NMR spectroscopy