An Evaluation of Optic Disc and Nerve Fiber Layer Examinations in Monitoring Progression of Early Glaucoma Damage

Quigley, Harry A.; Katz, Joanne; Derick, Robert J.; Gilbert, Donna; Sommer, Alfred

doi:10.1016/s0161-6420(92)32018-4

Cited by 531 publications

(333 citation statements)

References 36 publications

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“…26,29,30 The thinning observed in the RNFL inferior quadrant in patients with OH confirms previous observations, 31 although with a different percentage incidence that may be owing to the analysis method used. [32][33][34][35] This localized thinning of the RNFL might be an early sign of glaucoma 36 before any signs of optic nerve disorders or visual field impairment appear. The apparent absence of monochromatic visual field alterations in patients with OH, despite the finding of a very variable incidence of RNFL impairment, may be attributed to the fact that the perimetric methods used are not sufficiently sensitive.…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Cellini

Bernabini

Carbonelli

et al. 2006

Eye

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Purpose To study in ocular hypertension (OH) the retinal nerve fibre layer (RNFL) with optical coherence tomography (OCT) and the neuronal function with frequency-doubling technology (FDT) to assess which of the two methods was more sensitive in detecting early glaucomatous damage. Furthermore, a colour Doppler imaging (CDI) of the optic nerve was carried out to highlight any correlation with RNFL thickness and FDT abnormality. Materials and methods We enrolled 28 ocular hypertensive patients who underwent OCT of the RNFL and FDT. Moreover, we performed a CDI of the ophthalmic artery (OA), central retinal artery (CRA), and posterior ciliary arteries (PCAs). Results The patients with OH following OCT revealed a significant thinning in the RNFL as compared to the control group only in the inferior quadrant: 122.250714.091 vs 131.750710.729 lm (Po0.045). As regards FDT, there was a significant difference between the two groups only for pattern standard deviation (PSD): 3.87371.488 vs 1.93870.704 dB (Po0.044). In OH and in the control group, CDI resistance index (RI) in the OA was 0.76870.012 vs 0.74570.019 (Po0.022), in the CRA was 0.6670.012 vs 0.64570.019 (Po0.032), and in PCAs was 0.67370.039 vs 0.62270.012 (Po0.037). The OCT had a sensitivity of 83% but only in the inferior RNFL quadrant. The FDT-PSD revealed a sensitivity of 85%. Conclusions Both FDT and OCT detect early glaucomatous damage with a slightly superior sensitivity of FDT vs OCT. The CDI measurements suggest that circulatory abnormalities may have a role in the development of OCT and FDT damage.

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Section: Discussionmentioning

confidence: 99%

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Cellini

Bernabini

Carbonelli

et al. 2006

Eye

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“…Early detection of change to these structures is important as visual field defects may only develop after a large proportion of retinal ganglion cells have been damaged. 32,33 A good example of the issues surrounding ethnic differences is described as follows with the Heidelberg Retina Tomograph (confocal scanning laser ophthalmoscope), which uses a software analysis program named Moorfields Regression Analysis (MRA) to compare the subject's optic nerve and RNFL parameters to a normative database.…”

Section: Rnfl Retinal Thickness Macular Pigment and Retinal Vasculmentioning

confidence: 99%

Ethnicity and ocular imaging

Bourne

2010

Eye

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There exist ethnic differences in the prevalence of many ocular diseases. The ocular structures affected by these diseases can be imaged with devices that have increased in complexity over recent years. The purpose of this review is to explore what we mean by the term 'ethnicity' and what we know of ethnic differences in the structures of the eye that are commonly imaged. Finally, the implications of these ethnic differences are discussed in relation to the detection and monitoring of ocular disease that involves imaging instruments.

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“…O exame da camada de fibras nervosas da retina (CFN) com o uso da polarimetria de varredura a laser foi introduzido na propedêutica do glaucoma, com o objetivo de proporcionar o diagnóstico precoce da doença através da medida da espessura da CFN (6)(7)(8) . Vários autores salientam que os defeitos na CFN precedem, em até anos, os observados no campo visual (9,10) . A perimetria com estímulo azul em fundo amarelo é realizada nos mesmos princípios que a técnica convencional com fundo e estímulo brancos e baseia-se nos relatos que as células ganglionares Análise de regressão logística na combinação de métodos propedêuticos no diagnóstico do glaucoma…”

Section: Introductionunclassified

“…Vários autores salientam que os defeitos na CFN precedem, em até anos, os observados no campo visual (9,10) . A perimetria com estímulo azul em fundo amarelo é realizada nos mesmos princípios que a técnica convencional com fundo e estímulo brancos e baseia-se nos relatos que as células ganglionares…”

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Análise de regressão logística na combinação de métodos propedêuticos no diagnóstico do glaucoma

Fasolo

Júnior

Barbosa

et al. 2013

Arq. Bras. Oftalmol.

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INTRODUÇÃOO diagnóstico de glaucoma, classicamente se tem baseado na observação do disco óptico com características glaucomatosas, associado a defeitos correspondentes de campo visual, geralmente com níveis estatisticamente alterados de pressão intraocular (1) . Contudo, nem sempre o diagnóstico é evidente, principalmente em suas fases precoces. Desta forma, outras modalidades propedêuticas têm sido investigadas com a finalidade de proporcionar uma detecção mais precoce do dano glaucomatoso (1)(2)(3)(4)(5) . O exame da camada de fibras nervosas da retina (CFN) com o uso da polarimetria de varredura a laser foi introduzido na propedêutica do glaucoma, com o objetivo de proporcionar o diagnóstico precoce da doença através da medida da espessura da CFN (6)(7)(8) . Vários autores salientam que os defeitos na CFN precedem, em até anos, os observados no campo visual (9,10) . A perimetria com estímulo azul em fundo amarelo é realizada nos mesmos princípios que a técnica convencional com fundo e estímulo brancos e baseia-se nos relatos que as células ganglionares Análise de regressão logística na combinação de métodos propedêuticos no diagnóstico do glaucoma RESUMO

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An Evaluation of Optic Disc and Nerve Fiber Layer Examinations in Monitoring Progression of Early Glaucoma Damage

Cited by 531 publications

References 36 publications

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Ethnicity and ocular imaging

Análise de regressão logística na combinação de métodos propedêuticos no diagnóstico do glaucoma

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