An Evaluation of Non-Surgical Periodontal Therapy in Patients with Rheumatoid Arthritis

Roman-Torres, Caio Vinícius Gonçalves; Neto, J. Santos; Souza, M.A.C. de; Schwartz-Filho, Humberto Osvaldo; Brandt, William Cunha; Diniz, Ricardo E.A.S.

doi:10.2174/1874210601509010150

Cited by 22 publications

(13 citation statements)

References 24 publications

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“…The current study clinical parameters are in agreement with another study (14) who have shown that periodontal therapy in RA patients with chronic periodontitis showed enhancement in clinical parameters as evaluated by periodontal indices and laboratory tests. This may be attributed to the effective removal of infection source by subgingival mechanical debridement.…”

Section: Discussionsupporting

confidence: 92%

The Role of Porphoromonas Gingivalis in Rheumatoid Arthritis and Periodontitis by Using Subantimicrobial Dose Doxycycline

et al. 2019

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Purpose:The current study was directed to estimate the role of porphoromonas gingivalis in the relation between rheumatoid arthritis and periodontitis by using subantimicrobial dose doxycycline. Subjects and methods: The current study was accomplished on twenty patients who had mild or moderate chronic periodontitis and rheumatoid arthritis they were partitioned into two groups: Group I; ten patients were exposed to mechanical debridement only and Group II: ten patients were exposed to mechanical debridement added to receiving small dose doxycycline (SDD) as a host modulatory agent (20mg twice daily) for three months. Results: group I exhibited a greatly significant improvement in clinical parameter in correlation to group II after three months follow up. Group II showed the statistically significantly lowest percentage decrease in number of bacteria in synovial fluid Conclusion: The adjunct use of doxycycline as host modulatory agent improved the treatment outcomes when used with mechanical debridement in rheumatoid arthritis and patients with periodontitis. Codex : 45/1907 azhardentj@azhar.edu.eg

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Section: Discussionsupporting

confidence: 92%

The Role of Porphoromonas Gingivalis in Rheumatoid Arthritis and Periodontitis by Using Subantimicrobial Dose Doxycycline

et al. 2019

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“…Additionally, the relationship between PD and RA status was also described through an increased number of swollen joints, increased level of DAS28‐CRP, and rheumatoid factor in PD patients. A recent study also suggested that periodontal therapies can improve both clinical periodontal parameters and general laboratory testing in RA patients …”

Section: Discussionmentioning

confidence: 96%

Rheumatoid arthritis patients' oral health and disease activity

et al. 2019

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Aim Rheumatoid arthritis (RA) and periodontal diseases (PD) are common chronic, inflammatory, destructive and progressive diseases that may have similar pathophysiological mechanisms and risk factors. RA affects more than 1.5% of the world's population, with a higher percentage of females than males. PD is present in around 20% of the population and has multifactorial etiology. The purpose of this study is to describe patients' self‐reported oral health and the association with RA disease activity. Method Three hundred patients under treatment for RA from the Division of Rheumatology, Clinical Medicine, North Jutland Region Hospital, Hjørring, Denmark and were eligible for the study. Questionnaires were emailed to the patients and 164 completed answers were received. Results The mean age of the group of 164 patients (61% female) was 65 ± 11 years. The average value of Disease Activity Score of 28 joints was 2.31 ± 0.83. Only 12% of responders were active smokers. Patients estimated their status of their teeth and gingiva respectively as poor in 13% and 11% of cases, good, in 46% and 49%, and excellent, both as 40%. Spontaneous and/or provoked gingival bleeding were experienced by 15% and 49% of patients. Only 14% of patients declared feelings of loose or movable teeth and 10% declared difficulties in biting or chewing. Conclusions The status of oral cavity reported by Danish patients indicates a significant proportion with symptoms of gingival/periodontal disease, which may negatively influence RA activity and disease management. Cooperation between rheumatologists and dentists is important in oral health management in periodontal inflammation.

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“…In this respect, the lack of association between the prevalence of P. gingivalis or anti‐ P. gingivalis antibodies (e.g., in this study) with relation to RA raises important questions about their participation in the autoimmune process (Scher et al, , Ziebolz et al, ). Furthermore, recent studies have suggested that periodontal treatment alone can generate positive effects in the clinical manifestations of RA patients (Biyikoglu et al, , Okada et al, , Roman‐Torres et al, ); however, these studies have been conducted with small numbers of patients and lack a rigorous evaluation (Kaur, Bright, Proudman, & Bartold, ).…”

Section: Discussionmentioning

confidence: 99%

Salivary ammonia levels andTannerella forsythiaare associated with rheumatoid arthritis: A cross sectional study

Martínez-Rivera

Xibillé-Friedmann

González-Christen

et al. 2017

Clinical & Exp Dental Res

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The aim of this paper is to evaluate the relationship of salivary ammonium levels and the presence of bacteria with rheumatoid arthritis (RA) clinical disease activity in a cross‐sectional study of Mexican patients. From a periodontal and disease activity standpoint, 132 consecutive RA patients fulfilling clinical criteria were evaluated. Ammonia levels (including peptidyl arginine deiminase activity) were evaluated by colorimetric assay and the presence of Porphyromonas gingivalis, Tannerella forsythia, and Prevotella intermedia was evaluated by polymerase chain reaction (PCR) technique. After a multivariate analysis, adjusting for clinical and serological parameters, a significant association was only observed between severe periodontitis and probing depth with high RA disease activity. Additionally, in contrast to P. gingivalis, the presence of T. forsythia was significantly associated with high disease RA activity even after multivariable adjustment analysis. There was also a significant increase in ammonium levels in the high RA activity group and a significant correlation between salivary ammonia and RA disease activity but not with autoantibody titers. Similarly, we observed a significant increase in the ammonium levels derived from the cultures of P. gingivalis and T. forsythia, with respect to P. intermedia and S. gordonii cultures, or even healthy donors. These results suggest that RA activity is associated with severe periodontitis, high salivary ammonium levels and the presence of T. forsythia.

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An Evaluation of Non-Surgical Periodontal Therapy in Patients with Rheumatoid Arthritis

Cited by 22 publications

References 24 publications

The Role of Porphoromonas Gingivalis in Rheumatoid Arthritis and Periodontitis by Using Subantimicrobial Dose Doxycycline

The Role of Porphoromonas Gingivalis in Rheumatoid Arthritis and Periodontitis by Using Subantimicrobial Dose Doxycycline

Rheumatoid arthritis patients' oral health and disease activity

Salivary ammonia levels andTannerella forsythiaare associated with rheumatoid arthritis: A cross sectional study

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