An evaluation of large arteries compliance in man

Simón, A; Safar, M; Levenson, Jaime; London, Gérard M.; Levy, B. I.; Chau, Nguyen Phong

doi:10.1152/ajpheart.1979.237.5.h550

Cited by 89 publications

(75 citation statements)

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“…Validation of the model requires verification of the monoexponential form of the pressure decay during diastole and demonstration of a proportional relationship through zero, according to Equation 2, between the time constant of the diastolic pressure decay and the total peripheral resistance. The monoexponential decay of pressure during diastole, an important point extensively discussed elsewhere, 3 is verified in each patient of this study. Moreover, similarity of monoexponential diastolic pressure wave form in brachial artery and aorta from the point of view of the approximations involved in the calculation is a well-established point in the literature, 1011 enabling determination of the systemic arterial compliance from the brachial artery.…”

Section: Determination Of Systemic Arterial Compliancesupporting

confidence: 73%

Systemic arterial compliance in patients with arteriosclerosis obliterans of the lower limbs. Observations on the effect of intravenous propranolol.

Levenson

Simon²,

Fiessinger³

et al. 1982

Arteriosclerosis

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Hemodynamic parameters and systemic arterial compliance were measured in patients with arteriosclerosis obliterans of the lower limbs before and after acute administration of propranolol. Arterial compliance was evaluated from a simple viscoelastic model, enabling the calculation of diastoiic drainage and diastoiic blood flow as indices of the reservoir role of the large arteries in overall circulation, in comparing basal conditions with normal subjects of the same age, patients with arteriosclerosis obliterans exhibited a significant decrease in arterial compliance (p < 0.01) and heart rate (p < 0.02) with a significant increase in systolic pressure (p < 0.001). Diastoiic drainage was increased (p < 0.01) and was positively correlated with diastoiic time (r = 0.73, p < 0.001). Diastoiic blood flow remained within normal ranges (52 ± 2 vs 49 ± 3 ml/m 2 /sec). After acute propranolol intravenous administration, heart rate and stroke volume decreased (p < 0.001), while total peripheral resistance increased (p < 0.001). Systemic arterial compliance and diastoiic blood flow significantly decreased (p < 0.01). The study provided evidence that in patients with arteriosclerosis obliterans, the diastoiic blood flow was maintained in basal conditions despite the observed reduction in arterial compliance, and that intravenous propranolol administration decreased systemic arterial compliance and diastoiic blood flow. (Arteriosclerosis 2:266-271, May/June 1982)

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Section: Determination Of Systemic Arterial Compliancesupporting

confidence: 73%

Systemic arterial compliance in patients with arteriosclerosis obliterans of the lower limbs. Observations on the effect of intravenous propranolol.

Levenson

Simon²,

Fiessinger³

et al. 1982

Arteriosclerosis

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“…Moreover, the relaxant action of nicardipine on large arteries could play a greater role on the buffering function, assessed in our study by an increase in arterial compliance and a decrease in characteristic impedance, two indices that express the pulsatile behaviour of the large arteries of the forearm (O'Rourke, 1982). Indeed, it is now well known that in patients with essential hypertension, impairment of the buffering function, attested by the decrease in arterial compliance of large arteries (Simon et al, 1976), accompanies the constricted arterial vessels.…”

Section: Discussionmentioning

confidence: 57%

The effect of acute and chronic nicardipine therapy on forearm arterial haemodynamics in essential hypertension.

Levenson¹,

Simón²,

Bouthier³

et al. 1985

Brit J Clinical Pharma

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By using simultaneous recording curves obtained with pulsed Doppler velocimetry and strain gauge mechanography, forearm arterial haemodynamics were studied in 26 patients with mild to moderate essential hypertension. Fifteen patients received a single oral dose of nicardipine 40 mg, and 11 patients were treated with nicardipine 30 mg three times daily for 3 months. In both groups of patients there was a similar and significant (P less than 0.001) reduction in mean, systolic, and diastolic pressures. There was a slight increase in heart rate (P less than 0.05) after the single dose, but no change after 3 months of treatment. The diameter, blood velocity, and blood flow of the brachial artery increased significantly in both treatment groups. The decrease in forearm vascular resistance was significant for both treatment groups. Brachial artery compliance increased (P less than 0.01) and characteristic impedance decreased (P less than 0.01) after both single‐dose and long‐term therapy with nicardipine. In patients who received nicardipine for 3 months, there were close correlations between the baseline serum calcium level and the percent change in vascular resistance (r = ‐0.73, P less than 0.01), blood flow (r = 0.89, P less than 0.001), and blood velocity (r = 0.91. P less than 0.001) of the forearm. No correlation was found between the baseline serum calcium and the change in arterial pressure. This study provided evidence that the blood‐pressure‐lowering effect of nicardipine was accompanied by a direct vasodilatory action in the small and large arteries of the forearm. An increase in peripheral blood flow with concomitant improvement of arterial compliance are the consequences of these arterial actions.

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“…Once arterial wall degeneration is initiated, a positive feed back loop may be established whereby degeneration leads to pressure increases, ultimately leading to further vascular degeneration (46). In physiological conditions such as aging or HT, increased wall thickness and luminal diameter of large arteries reduce vascularity of bodily organs and tissues (54). As the artery dilates, wall tension and pulsatile stresses increase and accentuate arterial wall degeneration that has already occurred.…”

Section: Discussionmentioning

confidence: 99%

Low arterial compliance in young African-American males

Zion

Bond

Adams

et al. 2003

American Journal of Physiology-Heart and Circulatory Physiology

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Hypertension remains a common public health challenge because of its prevalence and increase in co-morbid cardiovascular diseases. Black males have disproportionate pathophysiological consequences of hypertension compared with any other group in the United States. Alterations in arterial wall compliance and autonomic function often precede the onset of disease. Accordingly, our purpose was to investigate whether differences exist in arterial compliance and autonomic function between young, healthy African-American males without evidence of hypertension and age- and gender-matched non-African-American males. All procedures were carried out noninvasively following rest. Arterial compliance was calculated as the integrated area starting at the well-defined nadir of the incisura of the dicrotic notch to the end of diastole of the radial artery pulse wave. Power spectral analysis of heart rate and blood pressure variability provided distributions representative of parasympathetic and sympathetic modulations and sympathovagal balance. Baroreflex sensitivity (BRS) was calculated using the sequence method. Thirty-two African-American and twenty-nine non-African-American males were comparable in anthropometrics and negative family history of hypertension. t-Tests revealed lower arterial compliance (5.8 ± 2.4 vs. 8.6 ± 4.0 mmHg · s; P = 0.0017), parasympathetic modulation (8.9 ± 1.1 vs. 9.7 ± 1.1 ln ms2; P = 0.0063), and BRS (13.7 ± 7.3 vs. 21.1 ± 8.5 ms/mmHg; P = 0.0007) and higher sympathovagal balance (2.9 ± 3.2 vs. 1.5 ± 1.1; P = 0.03) in the African-American group. In summary, differences exist in arterial compliance and autonomic balance in African-American males. These alterations may be antecedent markers of disease and valuable in the detection of degenerative cardiovascular processes in individuals at risk.

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An evaluation of large arteries compliance in man

Cited by 89 publications

References 0 publications

Systemic arterial compliance in patients with arteriosclerosis obliterans of the lower limbs. Observations on the effect of intravenous propranolol.

Systemic arterial compliance in patients with arteriosclerosis obliterans of the lower limbs. Observations on the effect of intravenous propranolol.

The effect of acute and chronic nicardipine therapy on forearm arterial haemodynamics in essential hypertension.

Low arterial compliance in young African-American males

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