An Evaluation of Information Technology of Gene Expression Profiles Processing Stability for Different Levels of Noise Component

Abstract

The paper presents the results of the research concerning an evaluation of information 1
 technology of gene expression profiles processing stability with the use of gene expression profiles 2
 with different levels of noise component. The information technology is presented as a structural 3
 block-chart, which contains all stages of the studied data processing. The hybrid model of objective 4
 clustering based on SOTA algorithm and the technology of gene regulatory networks reconstruction 5
 have been studied to evaluate the stability to the level of the noise component. The results of the 6
 simulation have shown that the hybrid model of objective clustering has high level of stability 7
 to noise component and vice versa, the technology of gene regulatory networks reconstruction is 8
 very sensitivity to level of noise component. The obtained results indicate the importance of gene 9
 expression profiles preprocessing at early stage of gene regulatory network reconstruction in order to 10
 remove background noise and non-informative genes in terms of used criteria