An Evaluation of Inflammatory and Nutritional Status of Breast Cancer Outpatients in a Tertiary Hospital in Nigeria

Izuegbuna, Ogochukwu; Olawumi, HO; Olatoke, Samuel; Durotoye, Idayat Adenike

doi:10.1080/01635581.2020.1870703

Cited by 6 publications

(5 citation statements)

References 60 publications

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“…In this study, there was statstically signi cant negative correlation(r=-0.491, P < 0.001) between serum albumin and SGA score level (Table 4). The nding is in harmony with the studies conducted at Nigeria (29) and Santamaria, Brazil (30) and Greek (42) reported a signi cantly low level of serum albumin in patients with cancer with malnutrition. Even though there is no evidence in contrary to the current nding in regards of all cancer types; there was evidence with restricted types of cancer.…”

Section: Discussionsupporting

confidence: 89%

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Blood Biomarkers as Potential Malnutrition Screening Alternatives Among Adult Cancer Patients on Treatment in Oncology Unit of Jimma Tertiary Hospital: A Cross- Sectional Analysis

Enkobahry¹,

Sime

Dilnesa

et al. 2023

Preprint

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Background: Cancer is becoming the most common global public health concern. Early malnutrition detection and treatment in patients with cancer is an important aspect of cancer management. Although Subjective global assessment (SGA) is a gold standard nutritional assessment tool, it is not routinely utilized due to it is tedious and needs patient literacy. Thus, early detection of malnutrition necessitates alternative parameters comparable with SGA. Therefore this study aims to evaluate serum albumin, Total Protein (TP), and Hemoglobin (Hgb) and their correlation with malnutrition in patients with cancer at Jimma Medical Center (JMC). Methods: Facility based cross-sectional study was conducted from October 15 to December 15, 2021 G.C at JMC among a total of 176 adult patients with cancer selected via a systematic sampling technique. Nutritional status and behavioural data were collected using the SGA tool and a structured questionnaire. Five ml of venous blood was collected and the level of serum albumin, TP and Hgb were measured using Cobas®6000 chemistry analyzer and hematology analyzer UniCel DxH 800. Descriptive statistics, independent t-test, Pearson’s correlation coefficient (r), and logistic regression analysis were implemented for analysis. Result: From the total of 176 study participants, 69.3% were females and the mean age was 50.1±13.7 years. Based on SGA, 61.4% of the patients were malnourished. There was a significant decrease in the mean level of serum albumin, TP and Hgb in malnourished as compared to well-nourished patients. Serum albumin(r=-0.491), TP(r=-0.270), and Hgb (r=-0.451) had a significant correlation with SGA tool. Stage IV cancer AOR=4.98 (1.23-20.07), Gastrointestinal (GI) cancer AOR=3.39(1.29-8.88) and malnutrition AOR=3.9(1.81-8.4) were significantly associated with hypoalbuminemia. Similarly, age of >64 years AOR = 6.44(1.55-26.67), GI cancer AOR= 2.92(1.01-6.29) and malnutrition AOR= 3.14(1.43-6.94) were significantly associated with hypoproteinemia; and stage-IV cancer AOR=3.94(1.11-13.35) and malnutrition AOR=3.8(1.82 -8.2) were significantly associated with low Hgb level. Conclusion and recommendation: Altered level of serum albumin, TP and Hgb was correlated with the SGA tool of malnutrition. Therefore, it is suggested to be used as an alternative or additional screening tool for prompt detection of malnutrition in adult patients with cancer

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Section: Discussionsupporting

confidence: 89%

“…According to a study, low albumin levels are directly associated with poor prognosis and survival of breast patients with cancer (26-28). According to various studies malnutrition is directly associated with serum albumin (29)(30)(31)(32). Serum total protein is mainly composed of albumin and globulin.…”

Section: Introductionmentioning

confidence: 99%

Blood Biomarkers as Potential Malnutrition Screening Alternatives Among Adult Cancer Patients on Treatment in Oncology Unit of Jimma Tertiary Hospital: A Cross- Sectional Analysis

Enkobahry¹,

Sime

Dilnesa

et al. 2023

Preprint

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“…Yu et al also observed a significant association between CRP and PG-SGA among patients with malignant tumours [99]. However, some other studies did not see any association between CRP and nutritional status [88,92]. In a study done by Read et al, patients with advanced colorectal cancer were initially found to have a positive correlation between SGA and CRP.…”

Section: C-reactive Proteinmentioning

confidence: 96%

“…They include albumin, prealbumin, C-reactive protein, transferrin, total lymphocyte count etc. However, more recently, inflammation-based scores and ratios are being seen as more sensitive markers than the traditional ones [87,88]. Other nutritional assessment tools use questionnaires incorporated with factors such as estimation of nutritional intake, laboratory parameters and calculation of unintentional weight loss.…”

Section: Inflammatory Markers Of Malnutritionmentioning

confidence: 99%

“…In oral cancer patients, Park et al showed that CAR was significantly associated with both PNI and mGPS, and was also a better marker for survival than the other markers [110]. Another related novel marker, CRP/Prealbumin ratio is seen as a prospective inflammatory nutritional prognostic tool in cancer [111], likewise the albumin/CRP ratio [8,88].…”

Section: Inflammation Scoresmentioning

confidence: 99%

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Inflammation-Based Markers of Nutrition in Cancer Patients

Izuegbuna¹

2023

Combating Malnutrition Through Sustainable Approaches

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Malnutrition and cachexia are common findings in cancer patients, and they predict poorer clinical outcomes. Close to half of cancer patients regardless of cancer type have malnutrition and will require one form of nutritional support either before or during treatment. The early identification of malnutrition is thus important to physicians and caregivers. The role of inflammation in the development and progression of malnutrition and cachexia is being unravelled. Increasing evidence shows that systemic inflammatory response and nutritional status are involved in tumour development and influence the clinical prognosis. Serum proteins such as albumin and prealbumin have traditionally been used by physicians to determine patient nutritional status. More recently, inflammation-based prognostic scores including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), C reactive protein-to-albumin ratio (CAR), prognostic nutritional index (PNI), Glasgow Prognostic Score (GPS) have shown promise and have begun to be used in clinical practice to predict prognosis of cancer patients. This chapter highlights the role and pathophysiology of inflammation-based markers in assessing malnutrition and cachexia and their relationship to clinical screening tools.

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