An evaluation of hemoglobin measurement tools and their accuracy and reliability when screening for child anemia in Rwanda: A randomized study

Parker, Megan; Han, Zhen; Abu-Haydar, Elizabeth; Matsiko, Eric; Iyakaremye, Damien; Tuyisenge, Lisine; Magaret, Amalia; Lyambabaje, Alexandre

doi:10.1371/journal.pone.0187663

Cited by 43 publications

(79 citation statements)

References 15 publications

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“…One study in 2018 on child anemia in Rwanda found a sensitivity of 89% and a specificity of 86%. 21 Lower and upper limits of agreement for both the Pronto-7 (Ϫ3.29 and 2.25, respectively) and the HemoCue 201ϩ (Ϫ3.57, 1.61, respectively) were too wide to recommend either device as a full replacement for a blood test because a potential difference of 2-3 g/dL in either direction is significant. However, the demonstrated sensitivity and specificity of either device, combined with their ease of use, means that these devices can potentially be utilized to screen for anemia in patients in the ED setting.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of Point-of-Care Testing for Anemia in the Emergency Department

et al. 2019

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BACKGROUND: Pulse oximetry has become the standard of care in emergency medicine, operating rooms, and medical wards for the monitoring of oxygenation, but the use of pulse oximetry for assessment of hemoglobin (Hb) is controversial. The purpose of this study was to compare the accuracy and precision of 2 point-of-care Hb measurement devices, the Pronto-7 and the HemoCue 201؉, to laboratory testing. METHODS: We studied a convenience sample of patients in the emergency department who required a complete blood count. We excluded patients in critical condition or those with elevated methemoglobin, impaired perfusion, or finger deformities. Each subject provided 2 capillary samples for measurement with the HemoCue 201؉ and 2 consecutive readings with the Pronto-7. We used Bland-Altman analysis to compare the performance of the point-of-care devices to laboratory measurements. We also determined the diagnostic performance for the detection of anemia by sex (Hb < 11.6 g/dL for females, Hb < 13.8 g/dL for males). RESULTS: 201 of the 350 subjects enrolled (57%) were female. Mean (SD) age was 50.9 (19.0) y. Complete data were available for 297 (84.9%) of the Pronto-7 readings and 323 (92.3%) of the HemoCue 201؉ readings. Mean (SD) laboratory Hb was 13.1 g/dL (2.3). Mean bias (Bland-Altman limits of agreement) for the Pronto-7 was ؊0.52 g/dL (؊3.29 to 2.25), and for the HemoCue 201؉ the mean bias was ؊0.98 g/dL (؊3.57 to 1.61). Sensitivity and specificity for diagnosis of anemia were 81.6% (95% CI 72.5-88.7) and 75.4% (95% CI 68.8-81.1) for the Pronto-7 and 99.1% (95% CI 94.8-100.0) and 71.0% (95% CI 64.4-76.9) for HemoCue 201؉. CONCLUSION: Both devices provided clinically useful methods to screen for anemia.

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Section: Discussionmentioning

confidence: 99%

Accuracy of Point-of-Care Testing for Anemia in the Emergency Department

et al. 2019

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“…Sensors are available for different‐sized fingers. However, the reading may be influenced by skin color …”

Section: Anemia Assessmentmentioning

confidence: 99%

Measurement and interpretation of hemoglobin concentration in clinical and field settings: a narrative review

Karakochuk

Hess

Moorthy

et al. 2019

Annals of the New York Academy of Sciences

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Anemia affects over 800 million women and children globally. Defined as a limited or insufficient functional red blood cell supply in peripheral blood, anemia causes a reduced oxygen supply to tissues and can have serious health consequences for women and children. Hemoglobin (Hb) concentration is most commonly measured for anemia diagnosis. Methods to measure Hb are usually invasive (requiring a blood sample); however, advances in diagnostic and clinical chemistry over the past decade have led to the development of new noninvasive methods. Accurate diagnosis at the individual level is important to identify individuals who require treatment. At the population level, anemia prevalence estimates are often the impetus for national nutrition policies or programs. Thus, it is essential that methods for Hb measurement are sensitive, specific, accurate, and reproducible. The objective of our narrative review is to describe the basic principles, advantages, limitations, and quality control issues related to methods of Hb measurement in clinical and field settings. We also discuss other biomarkers and tests that can help to determine the severity and underlying causes of anemia. In conclusion, there are many established and emerging methods to measure Hb concentration, each with their own advantages, limitations, and factors to consider before use.

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“…Therefore, there is an intense need for measuring TCAL to evaluate the efficacy of chemotherapy. Chemotherapy of cancer patients also results in lowering of Hb level (Parker et al, 2018) which causes improper drug delivery to tumor cells. If the concentration of chemotherapy is decreased at the cellular level, then the tumorous cells' proliferation becomes more aggressive.…”

Section: Research Articlementioning

confidence: 99%

Computer Simulation Modeling for Analyzing Mammary Gland Tumor Cells Aggression Level Restricted by Comparative Chemotherapy using Docetaxel and Doxorubicin Both with Cyclophosphamide

Adeel¹

2019

PVJ

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Using simulation modeling, this study analyzes "tumor cells aggression level" (TCAL) in mammary gland tumor-induced rat models by chemotherapy with docetaxel plus cyclophosphamide (TC) and doxorubicin plus cyclophosphamide (AC). The presented "simulation model for TC and AC" (SMTA) compares the efficacy of these drugs against TCAL by providing visual interaction of the drugs with tumor cells. It will help to decide the better drug combination for controlling TCAL. Mammary gland tumor was induced in 389 rat models using 2.5 mg Nmethyl-N-nitrosourea in 0.2 mL normal saline. For four chemo cycles, 198 rats were treated with TC and 191 with AC. Using published and derived equations, rules were programmed for observing interactions among SMTA agents. Twosample t-test, at α=0.05, was applied for statistical analysis of rat model results. For validation, paired t-test was used to compare SMTA, rat models, and published results. Analyzing rat models, there was a significant statistical difference between overall change in Hb level and WBC count affected by TC and AC. P-value=0.000<0.05, for both Hb level and WBC count, affected 3.98% and 5.13% respectively more by TC than AC. Providing SMTA with same drugs administration, given to rat models, 3.8% more tumor cells were controlled by AC than TC. Validating results from rat models and SMTA, there was no significant difference between means of overall trend in change of: (i) Hb level (p-value= 0.795>0.05), (ii) WBC count (p-value= 0.374>0.05). AC remained better than TC in controlling TCAL with a lesser effect on WBC count and Hb level. ©2019 PVJ. All rights reserved Key words: Agent-based simulation model Anticancer drugs comparison Chemotherapy Mammary gland tumor Tumor cells aggression level To Cite This Article: Adeel M, Asif M, Faisal MN, Ahmad S and Majeed W, 2019. Computer simulation modeling for analyzing mammary gland tumor cells aggression level restricted by comparative chemotherapy using docetaxel and doxorubicin both with cyclophosphamide. Pak Vet J, 39(3): 416-422. http://dx.

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An evaluation of hemoglobin measurement tools and their accuracy and reliability when screening for child anemia in Rwanda: A randomized study

Cited by 43 publications

References 15 publications

Accuracy of Point-of-Care Testing for Anemia in the Emergency Department

Accuracy of Point-of-Care Testing for Anemia in the Emergency Department

Measurement and interpretation of hemoglobin concentration in clinical and field settings: a narrative review

Computer Simulation Modeling for Analyzing Mammary Gland Tumor Cells Aggression Level Restricted by Comparative Chemotherapy using Docetaxel and Doxorubicin Both with Cyclophosphamide

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