An evaluation of E. coli in urinary tract infection in emergency department at KAMC in Riyadh, Saudi Arabia: retrospective study

Abstract

BackgroundUrinary tract infection (UTIS) is a common infectious disease in which level of antimicrobial resistance are alarming worldwide. Therefore, this study aims to describe the prevalence and the resistance pattern of the main bacteria responsible for UTIS Escherichia coli (E. coli).MethodsRetrospective chart review for patients admitted to emergency department and diagnosed with UTIS at KAMC, in Riyadh, Saudi Arabia between January to March 2008 was performed. Antimicrobial susceptibility to ampicillin, augmentin (amoxicillin/clavulanate), cefazolin, co-trimoxazole (sulfamethoxazole/trimethoprim), ciprofloxacin, and nitrofurantoin, and cefpodoxime was determined for 101 E. coli urinary isolates.ResultsEscherichia coli was the most prevalent pathogen contributing to UTIS representing 93.55, 60.24, and 45.83% of all pathogen isolated from urine culture of pediatric, adult, and elderly, respectively. High rates of resistance to ampicillin (82.76, 58, and 63.64%) and co-trimoxazole (51.72, 42, and 59.09%), among E. coli isolated from pediatric, adult and elderly respectively. Nitrofurantoin was the most active agent, followed by ciprofloxacin, augmentin and cefazolin. 22.77% of E. coli isolates exhibited multiple drug resistance (MDR). Among 66 and 49 isolates resistant to ampicillin and co-trimoxazole, respectively, 34.84 and 42.85% were MDR. In contrast, all isolates resistant to augmentin and nitrofurantoin were MRD, while 72.7 and 82.4% of isolates resistant to ciprofloxacin and cefazolin were MDR.ConclusionsHigh resistance was observed to ampicillin and co-trimoxazole which commonly used as empirical treatments for UTIS, limiting their clinical use. This necessitates continuous surveillance for resistance pattern of uropathogens against antibiotics.

FTIR-ATR spectroscopy as a diagnostic tool in the diagnosis of hypercholesterolemia induced by cholesterol-rich diet in rats

“…ESBL (Extended Spectrum Beta lactamase) and multiple drug resistance producing bacteria have made the treatment dif icult. In our study UTI was most common at the age 21-30, 65(26.3%) shown in (Table 1), UTI cases were more common in adult than other age groups (Alanazi et al, 2018). In this study, UTI cases was most common in female 164(66.4%) as shown in (Table 1) because of the short urethra, use of contraceptive, poor hygiene, pregnancy and sexual (Agbo, 2016) .…”

<p>Detection of Chromosomal and Plasmid-Mediated Quinolone Resistance Among <em>Escherichia coli</em> Isolated from Urinary Tract Infection Cases; Zagazig University Hospitals, Egypt</p>

“…Escherichia coli (E. coli) is a common human pathogen that is frequently implicated in causing urinary tract infections (UTIs) such as cystitis and pyelonephritis. 1 Fluoroquinolones (FQ) are broad-spectrum antibiotics that are commonly recommended for treatment of UTIs, in particular, those caused by genera and species of Enterobacteriaceae. 2 Following their widespread use, resistance to FQ has emerged globally.…”

A Case of Infantile Fungal Urinary Tract Infection

“…The most common causative agents are bacteria, and Escherichia coli is the most frequent uropathogen, accounting for 34.7-48.0 % of bacterial urinary tract infections in all age groups 1,4) . One study reported that Escherichia coli represented 93.6% of urinary tract infections in the pediatric population 5) .…”