An evaluation of different methods of producing the 1-Hz suppression effect

Abstract

A number of exploratory experiments produced results that suggested a simplified method of producing suppression of kindled behavior by 1-Hz sine-wave stimulation. This method involved determining the effective threshold intensity to produce kindled behavior (ETI,), followed 1 h later by stimulation with 1-Hz sine waves at the ETI, intensity for 5 min. Three hours later, a second 1-Hz trial occurred. Eighteen hours later, ETIl was determined. Four experiments with this method indicated clearly its effectiveness. However, when contrasted with the previous method used (a 1-60-1 sequence over a number of days with an intertrial interval of 1 h) both methods were equally effective.