An evaluation of automated methods for measurement of serum 25-hydroxyvitamin D

Wagner, David G.; Hanwell, Heather; Vieth, Reinhold

doi:10.1016/j.clinbiochem.2009.07.013

Cited by 172 publications

(145 citation statements)

References 35 publications

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“…The quantitative analyses of plasma 25(OH)D levels were conducted using a fully automated direct competitive chemiluminescent immunoassay (LIAISON 25-OH Vitamin D TOTAL; DiaSorin Inc., Stillwater, MN, USA). Within-run and total precision were 2.9-5.5% and 6.3-12.9%, respectively (Wagner et al, 2009). The parents and caregivers recorded the infant's food intake just before the examination using a 7-day food record.…”

Section: Methodsmentioning

confidence: 99%

Vitamin D status in infants: relation to nutrition and season

et al. 2011

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In a cross-sectional study, the primary objective was to assess the plasma concentration of 25-hydroxyvitamin D (25(OH)D) in healthy 9-month-old infants (n ¼ 255). The secondary objective was to evaluate nutritional variables and season in relation to 25(OH)D. The concentration of 25(OH)D was 77.2 ± 22.7 nmol/l (mean ± s.d.), ranging from 12 to 151 nmol/l. During the first 9 months, 97% received vitamin D supplementation (10 mg/day) and 89% had sufficient levels of 25(OH)D (50-250 nmol/l). In multiple regression analysis, controlled for body mass index (BMI) and intake of infant formula, a longer period of exclusive breastfeeding (P ¼ 0.026) and breastfeeding at 9 months (P ¼ 0.001) were both associated with lower levels. Dietary vitamin D intake was 4.4 ± 3.1 mg/day and in multiple regression analysis, controlled for BMI, intake of infant formula and mean energy intake, it was positively associated with 25(OH)D (P ¼ 0.001). There was a significant seasonal difference in 25(OH)D, with higher levels during summerÀautumn compared with winterÀspring (P ¼ 0.021) after control for BMI.

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Section: Methodsmentioning

confidence: 99%

Vitamin D status in infants: relation to nutrition and season

et al. 2011

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“…Serum was divided into 0.5 ml volumes in polypropylene cryogenic vials, frozen at -70°C and stored in freezers equipped with temperature alarms. Serum was analysed by a 25(OH)D analysis laboratory (Heartland Laboratories, Ames, IA, USA), using a US Food and Drug Administrationapproved direct, competitive chemiluminescence immunoassay, the DiaSorin LIAISON Assay (DiaSorin, Stillwater, MN, USA) [12]. The inter-and intra-assay coefficients of variation were 12.4% and 5.4%, respectively [12].…”

Section: Methodsmentioning

confidence: 99%

“…Serum was analysed by a 25(OH)D analysis laboratory (Heartland Laboratories, Ames, IA, USA), using a US Food and Drug Administrationapproved direct, competitive chemiluminescence immunoassay, the DiaSorin LIAISON Assay (DiaSorin, Stillwater, MN, USA) [12]. The inter-and intra-assay coefficients of variation were 12.4% and 5.4%, respectively [12]. Measurements were validated according to the Vitamin D External Quality Assessment Scheme.…”

Section: Methodsmentioning

confidence: 99%

Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case–control study

et al. 2012

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Aims/hypothesis Low serum 25-hydroxyvitamin D [25 (OH)D] concentration may increase risk of insulinrequiring diabetes.Methods A nested case-control study was performed using serum collected during 2002-2008 from military service members. One thousand subjects subsequently developed insulin-requiring diabetes. A healthy control was individually matched to each case on blood-draw date (±2 days), age (±3 months), length of service (±30 days) and sex. The median elapsed time between serum collection and first diagnosis of diabetes was 1 year (range 1 month to 10 years). Statistical analysis used matched pairs and conditional logistic regression. Results ORs for insulin-requiring diabetes by quintile of serum 25(OH)D, from lowest to highest, were 3.5 (95% CI 2.0, 6.0), 2.5 (1.5, 4.2), 0.8 (0.4, 1.4), 1.1 (0.6, 2.8) and 1.0 (reference) (p trend <0.001). The quintiles (based on fifths using serum 25(OH)D concentration in the controls) of serum 25(OH)D in nmol/l, were <43 (median 28), 43-59 (median 52), 60-77 (median 70), 78-99 (median 88) and ≥100 (median 128). Conclusions/interpretation Individuals with lower serum 25(OH)D concentrations had higher risk of insulinrequiring diabetes than those with higher concentrations. A 3.5-fold lower risk was associated with a serum 25 (OH)D concentration ≥60 nmol/l.

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“…Calcium, phosphorus, and albumin were time-varying and available for each annual visit. 45 Serum PTH and 25(OH)D and plasma C-terminal FGF23 were first measured 3-6 months after baseline in 379, 388, and 388 participants, respectively, and then at alternating visits from the second annual visit onwards [45][46][47] ; both the baseline and average values were considered for PTH, FGF23, and 25(OH)D. Serum calcium concentrations were corrected for albumin: corrected calcium=measured calcium+0.83(4.02albumin).…”

Section: Assessment Of Ckd Characteristics and Risk Factorsmentioning

confidence: 99%

Fracture Burden and Risk Factors in Childhood CKD

Denburg

Kumar

Jemielita

et al. 2016

Journal of the American Society of Nephrology

110

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Childhood chronic kidney disease (CHD) poses multiple threats to bone accrual; however, the associated fracture risk is not well characterized. This prospective cohort study included 537 CKD in Children (CKiD) participants. Fracture histories were obtained at baseline, at years 1, 3, and 5 through November 1, 2009, and annually thereafter. We used Cox regression analysis of first incident fracture to evaluate potential correlates of fracture risk. At enrollment, median age was 11 years, and 16% of patients reported a prior fracture. Over a median of 3.9 years, 43 males and 24 females sustained incident fractures, corresponding to 395 (95% confidence interval [95% CI], 293-533) and 323 (95% CI, 216-481) fractures per 10,000 person-years, respectively. These rates were 2-to 3-fold higher than published general population rates. The only gender difference in fracture risk was a 2.6-fold higher risk in males aged $15 years (570/10,000 person-years, adjusted P=0.04). In multivariable analysis, advanced pubertal stage, greater height Z-score, difficulty walking, and higher average log-transformed parathyroid hormone level were independently associated with greater fracture risk (all P#0.04). Phosphate binder treatment (predominantly calcium-based) was associated with lower fracture risk (hazard ratio, 0.37; 95% CI, P=0.03). Participation in more than one team sport was associated with higher risk (hazard ratio, 4.87; 95% CI, 2.21-10.75; P,0.001). In conclusion, children with CKD have a high burden of fracture. Regarding modifiable factors, higher average parathyroid hormone level was associated with greater risk of fracture, whereas phosphate binder use was protective in this cohort.

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An evaluation of automated methods for measurement of serum 25-hydroxyvitamin D

Cited by 172 publications

References 35 publications

Vitamin D status in infants: relation to nutrition and season

Vitamin D status in infants: relation to nutrition and season

Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case–control study

Fracture Burden and Risk Factors in Childhood CKD

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