An evaluation of association between common variants in C4BPB/C4BPA genes and schizophrenia

Wang, Shuihong; Lu, Houquan; Ni, Jiazuan; Zhang, Jiangtao; Tang, Wenxin; Lü, Wei; Cai, Jun; Zhang, Chen

doi:10.1016/j.neulet.2015.02.005

Cited by 9 publications

(8 citation statements)

References 35 publications

(33 reference statements)

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“…We have examined the association of schizophrenia with the gene encoding C4-binding protein ( C4BPB / C4BPA ), a potent circulating soluble inhibitor of the classical and lectin pathways of complement. However, our results did not support the involvement of C4BPB / C4BPA in schizophrenia [ 22 ]. Here, we aimed to investigate the association of C3 , another critical factor in complement system, with schizophrenia in Chinese Han population.…”

Section: Discussioncontrasting

confidence: 71%

“…For the genetic analysis, a total of 647 schizophrenia patients recruited from Tongde Hospital of Zhejiang Province and The Seventh People’s Hospital of Hangzhou. The inclusion criteria for this study were according to our previous ones [ 20 , 21 , 22 ]. All patients (1) met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for schizophrenia; (2) were not first-episode; (3) had no chronic physical disease or other psychiatric disorder aside from schizophrenia.…”

Section: Methodsmentioning

confidence: 99%

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A Preliminary Genetic Analysis of Complement 3 Gene and Schizophrenia

Zhang

et al. 2015

PLoS ONE

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Complement pathway activation was found to occur frequently in schizophrenia, and complement 3 (C3) plays a major role in this process. Previous studies have provided evidence for the possible role of C3 in the development of schizophrenia. In this study, we hypothesized that the gene encoding C3 (C3) may confer susceptibility to schizophrenia in Han Chinese. We analyzed 7 common single nucleotide polymorphisms (SNPs) of C3 in 647 schizophrenia patients and 687 healthy controls. Peripheral C3 mRNA expression level was measured in 23 drug-naïve patients with schizophrenia and 24 controls. Two SNPs (rs1047286 and rs2250656) that deviated from Hardy-Weinberg equilibrium were excluded for further analysis. Among the remaining 5 SNPs, there was no significant difference in allele and genotype frequencies between the patient and control groups. Logistic regression analysis showed no significant SNP-gender interaction in either dominant model or recessive model. There was no significant difference in the level of peripheral C3 expression between the drug-naïve schizophrenia patients and healthy controls. In conclusion, the results of this study do not support C3 as a major genetic susceptibility factor in schizophrenia. Other factors in AP may have critical roles in schizophrenia and be worthy of further investigation.

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Section: Discussioncontrasting

confidence: 71%

Section: Methodsmentioning

confidence: 99%

A Preliminary Genetic Analysis of Complement 3 Gene and Schizophrenia

Zhang

et al. 2015

PLoS ONE

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“…For example, ACP5 was differentially expressed in the four groups; APOE , C4BPA , C7 , and ACP5 were highly expressed at estrus; SULT1C3 , CYP17A1 , and GJA1 were highly expressed at diestrus. In addition, it has been reported that SULT1C3 28 and CYP17A1 29 are related to steroid metabolism pathway, APOE was related to lipid metabolism 30 , and C7 31 and C4BPA 32 were related to the immune system. The expression patterns of these 7 DEGs were in agreement with our RNA-seq findings.…”

Section: Resultsmentioning

confidence: 99%

Genome-wide differential mRNA expression profiles in follicles of two breeds and at two stages of estrus cycle of gilts

Chu

Zhou

et al. 2017

Sci Rep

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Estrus expression by gilts and sows is hereditable and important for heat detection. To better understand the molecular biological mechanisms of estrus expression in gilts, the mRNA expression profiles of follicular tissue from Large White gilts in diestrus (LD, n = 3) and estrus (LE, n = 3), and Chinese indigenous Mi gilts in diestrus (MD, n = 2) and estrus (ME, n = 3) were investigated using RNA sequencing. We detected 122,804-335,295 SNPs, 6,140-14,947 InDel and 12 types of AS events (39.57% TSS, 34.90% TTS) in 11 samples. A total of 2,838 differentially expressed genes (DEGs) were found in LD vs MD, LE vs ME, LE vs LD, or ME vs MD comparisons. Two DEGs (ACP5 and PIGS) were observed in all comparisons. Two new genes (ENSSSCG00000028235 and ENSSSCG00000021903) were exclusively expressed in Mi and Large White gilts, respectively. Bioinformatics analyses indicate that these DEGs are involved in single-organism process, catalytic activity, cell adhesion and enriched in ECM-receptor interaction, olfactory transduction, ovarian steroidogenesis, steroid biosynthesis and CAMs signaling pathways. These results of RNA-Seq have provided important information for screening the key functional genes or molecular markers of estrus expression in gilts.

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“…The genes included OLFM4, RASAL2, BHZ, DEFA1B, DEFA4, C4BPA, CPA5, GPRC5C, LTF, ADAMTS15, CLEC12A and ELANE. The C4BPA has been reported in studies of individuals with psychotic experiences 37 and schizophrenia 38 . The ELANE gene encodes for a protein that is found in neutrophils and plays a role in inflammation and in fighting infection.…”

Section: Discussionmentioning

confidence: 97%

Genome-wide gene expression changes in postpartum depression point towards an altered immune landscape

et al. 2021

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Maternal postpartum depression (PPD) is a significant public health concern due to the severe negative impact on maternal and child health and well-being. In this study, we aimed to identify genes associated with PPD. To do this, we investigated genome-wide gene expression profiles of pregnant women during their third trimester of pregnancy and tested the association of gene expression with perinatal depressive symptoms. A total of 137 women from a cohort from the University of North Carolina, USA were assessed. The main phenotypes analysed were Edinburgh Postnatal Depression Scale (EPDS) scores at 2 months postpartum and PPD (binary yes/no) based on an EPDS cutoff of 10. Illumina NextSeq500/550 transcriptomic sequencing from whole blood was analysed using the edgeR package. We identified 71 genes significantly associated with postpartum depression scores at 2 months, after correction for multiple testing at 5% FDR. These included several interesting candidates including TNFRSF17, previously reported to be significantly upregulated in women with PPD and MMP8, a matrix metalloproteinase gene, associated with depression in a genome-wide association study. Functional annotation of differentially expressed genes revealed an enrichment of immune response-related biological processes. Additional analysis of genes associated with changes in depressive symptoms from recruitment to 2 months postpartum identified 66 genes significant at an FDR of 5%. Of these genes, 33 genes were also associated with depressive symptoms at 2 months postpartum. Comparing the results with previous studies, we observed that 15.4% of genes associated with PPD in this study overlapped with 700 core maternal genes that showed significant gene expression changes across multiple brain regions (P = 7.9e-05) and 29–53% of the genes were also associated with estradiol changes in a pharmacological model of depression (P values range = 1.2e-4–2.1e-14). In conclusion, we identified novel genes and validated genes previously associated with oestrogen sensitivity in PPD. These results point towards the role of an altered immune transcriptomic landscape as a vulnerability factor for PPD.

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An evaluation of association between common variants in C4BPB/C4BPA genes and schizophrenia

Cited by 9 publications

References 35 publications

A Preliminary Genetic Analysis of Complement 3 Gene and Schizophrenia

A Preliminary Genetic Analysis of Complement 3 Gene and Schizophrenia

Genome-wide differential mRNA expression profiles in follicles of two breeds and at two stages of estrus cycle of gilts

Genome-wide gene expression changes in postpartum depression point towards an altered immune landscape

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