An evaluation of albumin microcapsules prepared using a multiple emulsion technique

Shah, Mandar V.; Gennaro, Mario di; Suryakasuma, H.

doi:10.3109/02652048709021816

Cited by 31 publications

(11 citation statements)

References 5 publications

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“…The equation m 0 1=3 À m 1=3 ¼ Kt, proposed by Hixson and Crowell 11 for the dissolution of powder, assumes that the dissolution of powders is independent of the initial particle diameter (where m o in the equation is the initial drug concentration, m is the amount of drug left undissolved at time t, and K is the dissolution rate constant). The first-order model as adopted by Shah et al 12 is given by F ¼ 1 À e ÀKt , where F is the fraction of the drug dissolved at time t and K is the dissolution rate constant. The percent ibuprofen released from single-unit and multipleunit formulations was plotted against time on a log-log scale and analyzed for linearity using the least-squares method.…”

Section: Kinetics Of Drug Releasementioning

confidence: 99%

In vitro and in vivo evaluation of single-unit commercial conventional tablet and sustained-release capsules compared with multiple-unit polystyrene microparticle dosage forms of ibuprofen

Shunmugaperumal

2006

AAPS PharmSciTech

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The major aims of the present study were (1) to select a multiple-unit formulation that matched the in vitro dissolution profile of single-unit sustained-release commercial capsules, (2) to compare the sustaining/controlling efficacy of the selected multiple-unit formulation with that of the single-unit commercial conventional tablet and sustainedrelease capsules, and (3) to determine whether an in vitroin vivo correlation exists for single-and multiple-unit formulations. Ibuprofen (20%-60% wt/wt)-loaded multipleunit polystyrene microparticles were prepared by an emulsionsolvent evaporation method from an aqueous system. The in vitro release profiles obtained in phosphate buffer of pH 6.8 for drug-loaded polystyrene microparticles and for commercial sustained-release capsules (Fenlong-SR, 400 mg) were compared. Since the microparticles with 30% ibuprofen load showed a release profile comparable to that of the Fenlong-SR release profile, the microparticles with this drug load were considered to be the optimized/selected formulation and, therefore, were subjected to stability study and in vivo study in human volunteers. A single-dose oral bioavailability study revealed significant differences in C max , T max , t 1/2a , t 1/2e , K a , K e , and AUC between the conventional tablet and optimized or Fenlong-SR capsule dosage forms. However, all the parameters, with the exception of K a along with relative bioavailability (F) and retard quotient (R Δ ), obtained from the optimized ibuprofenloaded microparticles were lower than that obtained from the commercial Fenlong-SR formulation. Furthermore, linear relationship obtained between the percentages dissolved and absorbed suggests a means to predict in vivo absorption by measuring in vitro dissolution.

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Section: Kinetics Of Drug Releasementioning

confidence: 99%

In vitro and in vivo evaluation of single-unit commercial conventional tablet and sustained-release capsules compared with multiple-unit polystyrene microparticle dosage forms of ibuprofen

Shunmugaperumal

2006

AAPS PharmSciTech

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“…Multi-core albumin MS can be prepared by (O/W)/O suspension [Shah et al, 1987]. The salient steps involved in their preparation are: 1) a dispersion of sulfamidazole particles in corn oil can be mixed with 1.5-2 volumes of albumin solution and the mixture stirred at 250 rpm for 10 min to produce an O/W suspension; 2) addition of this O/W suspension to approximately 5 volumes of light mineral oil containing polysorbate-80 with stirring at 500 rpm for 2 min produces the corresponding (O/W)/O suspension; 3) immersion of this multiple emulsion suspension mixture in an 801C water bath with gentle stirring for 2 h effects thermal stabilization of the albumin load around the solid-in-oil core; and 4) the suspension mixture can be diluted with isopropanol and the particles recovered by filtration and washing with isopropanol.…”

Section: Multiple Suspension Systemmentioning

confidence: 99%

Biopolymer albumin for diagnosis and in drug delivery

Patil¹

2003

Drug Development Research

152

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This article reviews the developmental stages and strategies used to assess the biomedical utility of biopolymer albumin from the 1970s to early 2002. The basic method and mechanism(s) of preparation of albumin microspheres and subsequent modifications made to overcome the drawbacks of earlier approaches and the need for further developments are discussed, as are the processing parameters and the level of various ingredients affecting the physicochemical properties of the albumin microspheres. Different equations proposed by various investigators to modulate in vitro release kinetics are reviewed. The microscopic structural and surface properties, the chemical modification of the biopolymer (e.g., cationization, tagging with amino acids and sugar moieties) for tissue specificity or to influence the release profile and biodegradation are discussed. An array of potential diagnostic applications and the use of albumin microspheres as a drug delivery system are reviewed. Drug Dev.

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“…The amount of drug present in the matrices is about 85.4 ± 0.78%. In vitro release data were fitted to various kinetic models such as zero order, first order, Higuchi release, and Korsmeyer-Peppas to evaluate the mechanism of drug release without and under electric field separately [22][23][24][25]. The rate constants ( ) were calculated from the slope of the respective plots and high correlation ( 2 ) was observed for the Higuchi model ( Table 1).…”

Section: Kinetics Of Drug Release Profilementioning

confidence: 99%

Fast Release of Sulfosalicylic Acid from Polymer Implants Consisting of Regenerated Cellulose/γ-Ferric Oxide/Polypyrrole

Chowdhury

Robertson

Al‐Jumaily

et al. 2014

Journal of Applied Chemistry

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This work presents a comparative study on the rate of drug release from implantable matrices induced by electric and magnetic fields separately for better biomedical applications. The matrices were prepared by coating -ferric oxide dispersed regenerated cellulose film by polypyrrole doped with sulfosalicylic acid as an anti-inflammatory drug. The drug release mechanisms were studied under both the electric and the magnetic fields separately in an acetate buffer solution with pH 5.5 and temperature 37 ∘ C during a period of 5 hours. The amount of drug released was analysed by UV-Vis spectrophotometry. The mechanism of drug release from the matrices under electric field includes expansion of conductive polymer chain and the electrostatic force between electron and drug. The drug release mechanism from the matrices under magnetic field is based on the fact that the heat produced locally by magnetic particles loosens the polymer (polypyrrole) chain surrounding the particles. As a result, the drugs attached to the polypyrrole chain come out to the release medium. The matrices showed fast release of drug, that is, more than 60% of the loaded drug was released within 1 h, and are ideal for the treatment of illness in an emergency care.

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An evaluation of albumin microcapsules prepared using a multiple emulsion technique

Cited by 31 publications

References 5 publications

In vitro and in vivo evaluation of single-unit commercial conventional tablet and sustained-release capsules compared with multiple-unit polystyrene microparticle dosage forms of ibuprofen

In vitro and in vivo evaluation of single-unit commercial conventional tablet and sustained-release capsules compared with multiple-unit polystyrene microparticle dosage forms of ibuprofen

Biopolymer albumin for diagnosis and in drug delivery

Fast Release of Sulfosalicylic Acid from Polymer Implants Consisting of Regenerated Cellulose/γ-Ferric Oxide/Polypyrrole

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