An Evaluation of a Prototype Jobs Program Using an Event History Analysis of AFDC Cases

Barton, Thomas R.; Pillai, Vijayan K.

doi:10.1177/0193841x9301700103

Cited by 5 publications

(3 citation statements)

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“…To further verify whether hIAPP monomers actually form parallel dimer structures, we clustered low energy structures obtained from DMD simulations using a hierarchal clustering algorithm 42 (Methods) and examined the centroid representatives of the most populated clusters ( Fig. S2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Similar structures with consecutive frames were then filtered out using a sliding window (~3000–4000 DMD time units). The resulting configurations were clustered into fifty clusters using the hierarchical clustering algorithm, OC 42 . Within each cluster, the conformation that has the minimum RMSD to all other structures was chosen as the centroid.…”

Section: Methodsmentioning

confidence: 99%

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Inhibition of IAPP aggregation by insulin depends on the insulin oligomeric state regulated by zinc ion concentration

Nedumpully-Govindan

Ding

2015

Sci Rep

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While islet amyloid polypeptide (IAPP) aggregation is associated with β-cell death in type-II diabetes (T2D), environmental elements of β-cell granules — e.g. high concentrations of insulin and Zn2+ — inhibit IAPP aggregation in healthy individuals. The inhibition by insulin is experimentally known, but the role of Zn2+ is controversial as both correlations and anti-correlations at the population level are observed between T2D risk and the activity of a β-cell specific zinc ion transporter, ZnT8. Since Zn2+ concentration determines insulin oligomer equilibrium, we computationally investigated interactions of IAPP with different insulin oligomers and compared with IAPP homodimer formation. We found that IAPP binding with insulin oligomers competes with the formation of both higher-molecular-weight insulin oligomers and IAPP homodimers. Therefore, zinc deficiency due to loss-of-function ZnT8 mutations shifts insulin oligomer equilibrium toward zinc-free monomers and dimers, which bind IAPP monomers more efficiently compared to zinc-bound hexamers. The hetero-molecular complex formation prevents IAPP from self-association and subsequent aggregation, reducing T2D risk.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Inhibition of IAPP aggregation by insulin depends on the insulin oligomeric state regulated by zinc ion concentration

Nedumpully-Govindan

Ding

2015

Sci Rep

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“…the effectiveness of treatment in reducing heroin careers (Brunswick & Messeri, 1986), and . a welfare employment program's impact on welfare receipt (Barton & Pillai, 1993). These evaluations, using an event history analysis technique, yield outcome and impact information more consistent with what policymakers and program planners intend for their programs.…”

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confidence: 99%

Using an Event History Analysis to Evaluate Social Welfare Programs

Barton

Pillai

1995

Research on Social Work Practice

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This article presents an overview of how an event history analysis can be used to evaluate social welfare programs' impacts on events and the timing of events. An overview of event history analysis is presented, including a discussion of events and spells, hazards, censoring, duration intervals, longitudinal databases, design issues, and life table and multivariate analysis techniques. The article concludes with an example of how an event history analysis was used to evaluate the Aid to Families with Dependent Children (AFDC) program.A goal of many social welfare programs is to change people's behavior. They attempt to change behaviors such as child and spouse abuse, drunken driving, substance abuse, suicides, moving into poverty, becoming unemployed, and so on. The list of intended changed behaviors is as long and varied as the list of practice areas and programs.Many of the intended impacts have one thing in common, however. They intend to reduce, to eliminate, to increase, or to encourage the occurrence of an event. The purpose of a child abuse prevention program is to eliminate or reduce the incidence of child abuse. Suicide prevention programs attempt to reduce the incidence of suicide. Employment programs attempt to have people obtain employment. All of these programs focus on events and whether the event occurs. An event marks the occurrence of a qualitative change. The timing of such qualitative changes and the duration of time through which they persist have long been of concern to social work practitioners and program evaluators. In fact, enabling and sustaining desirable behaviors over time is a fundamental social work objective. Until recently, social workers have lacked adequate methodological tools to examine qualitative changes or events over time. Within the last few years researchers have begun to use an &dquo;event history&dquo; analysis technique to

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